FASTING SERUM GHRELIN LEVELS IS NEGATIVELY ASSOCIATED WITH BODY MASS INDEX, CHOLESTEROL, TRIGLYCERIDE AND C-REACTIVE PROTEIN

Öz

Objective The aim of this study is to evaluate the relationship of ghrelin hormone with body mass index (BMI) in cohort of adult men and women subsequently categorized from normal weight to morbidly obese based on BMI criteria. The relationship among the total ghrelin, serum lipids and C-reactive protein (CRP) was also evaluated. Materials and Methods Two-hundred sixty men (n=151) and women (n=109) between the ages of 20 and 59 years were recruited from Sleep Disorder Center of Medicine Faculty of Süleyman Demirel University and of Isparta Gülkent State Hospital. Fasting plasma total ghrelin, CRP, serum lipids and glucose levels were measured after overnight fasting. Results Ghrelin levels were found to be statistically significantly lower in obese subjects (P<0.001), Glucose levels were clinically higher in obese subjects but not statistically significant. Fasting plasma ghrelin was negatively correlated with BMI, cholesterol, triglyceride (TG) and CRP (r=-0,402, P<0,01; r=0,259, p=0,01; r=0,137, p=0,05; r=0,146, p=0,05), respectively). There was weak significant correlation between ghrelin and glucose (r=0,131, p=0,05). Conclusion Obese subjects have low fasting ghrelin levels that they are significantly related to glucose, CRP, Cholesterol, triglyceride and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity. 

Anahtar Kelimeler

• Obesity
• Serum lipids
• Inflammation
• Adults
• Ghrelin

AÇLIK SERUM GRELİN DÜZEYLERİ VÜCUT KİTLE İNDEKSİ, KOLESTEROL, TRİGLİSERİT VE C- REAKTİF PROTEİN İLE NEGATİF İLİŞKİLİDİR

Öz

Amaç: Bu çalışmanın amacı, vücut kitle indeksi (VKİ) kriterlerine göre normal ağırlıktan morbid obeze kadar gruplandırılan erişkin erkek ve kadın kohortunda grelin hormonunun VKİ, serum lipitleri ve C-reaktif protein (CRP) ile ilişkisini değerlendirmektir.

Gereç ve Yöntem: Isparta Gülkent Devlet Hastanesi Göğüs Hastalıkları Uyku Laboratuarı ve Süleyman Demirel Üniversitesi Tıp Fakültesi Uyku Hastalıkları Merkezine başvuran 20-59 yaş arası toplam iki yüz altmış erkek (n = 151) ve kadın (n = 109) çalışmaya dahil edildi. Toplam grelin, CRP, serum lipitleri ve glukoz seviyeleri gece açlığından sonra ölçüldü.

Bulgular: Grelin düzeyleri obez olgularda istatistiksel olarak anlamlı derecede düşük bulundu (P <0.001), Glikoz düzeyleri obez olgularda klinik olarak daha yüksekti ancak istatistiksel olarak anlamlı değildi. Açlık plazma grelin, VKİ, kolesterol, trigliserid ve CRP ile negatif korelasyonlar gösterdi (sırasıyla, r = -0.402, P <0.01; 0,259, p = 0,01; 0,137, p = 0,05; r = 0,146, p = 0,05). Grelin ve glukoz arasında zayıf anlamlı korelasyon vardı (r = 0,131, p = 0,05).

Sonuç: Obez bireylerin grelin düzeylerinin düşük olması glikoz, CRP, kolesterol, trigliserid ve vücut kitle indeksi ile anlamlı derecede ilişkilidir. Grelinin insan obezitesinin patogenezindeki rolünü belirlemek için daha ileriye dönük çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Obezite
• Serum lipidleri
• İnflamasyon
• Yetişkin
• Grelin

Kaynakça

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