Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi

Çiğdem Aydın Acar; Zafer Çetin; Orhan Kemal Yücel; Utku Iltar; Ozan Salim; Sibel Berker Karaüzüm

doi:10.17343/sdutfd.535002

Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi

Öz

Amaç: Kronik miyeloid lösemi (KML) hastalarında Philadelphia (Ph) kromozomunun yanında, ilave kromozom anomalilerin varlığı hastalık progresyonu ile ilişkili klonal evrimi göstermektedir. Bu nedenle, geniş hasta serilerinde sitogenetik analiz sonuçlarının değerlendirilmesi, KML hastalarında tanı kadar, hastalığın prognozu açısından da büyük öneme sahiptir.

Gereç ve Yöntem: Bu çalışmada, KML tanılı 225 hastanın kemik iliği örneklerinden elde edilmiş sitogenetik ve FISH analiz sonuçları retrospektif olarak incelenmiştir.

Bulgular: 225 hastanın 15’inde (%6,7) klasik Ph kromozomuna ilave kromozomal abnormalite belirlenmiştir. Bu hastalardan 2’sinde minör rota (%0,9), 10’unda majör rota (%4,4) kromozom anomalileri, ayrıca 3 hastada sırasıyla ilave kromozom anomalisi olarak t(8;19), t(5;7) ve 16 numaralı kromozomun kaybı gözlenmiştir. İlave kromozomal abnormaliteler içerisinde en yaygın olarak ikinci bir Ph kromozomunun varlığı ve bunu takiben 8 ve 19 numaralı kromozomların trizomisi belirlenmiştir. 225 hastanın 7’sinde (%3,1) ise varyant philadelphia kromozom translokasyonu gösterilmiştir ve bu varyant translokasyonlardan t(X;9;22)( p11.4;q34;q11) ve t(20;9;22)(p13;q34;q11) ise bizim çalışmamızda ilk kez rapor edilmiştir.

Sonuç: Çalışmamızda sonuç olarak, t(9;22) translokasyonuna ilave kromozom abnormalitelerinin ve varyant Ph translokasyonlarının KML kliniği ile ilişkisi ve literatüre göre değerlendirilmesi yapılmıştır.

Anahtar Kelimeler

Kronik miyeloid lösemi,İlave kromozom anomalileri,KML

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Çiğdem Aydın Acar
0000-0002-1311-2314
Türkiye

Zafer Çetin Bu kişi benim
Türkiye

Orhan Kemal Yücel Bu kişi benim
Türkiye

Utku Iltar Bu kişi benim
Türkiye

Ozan Salim
Türkiye

Sibel Berker Karaüzüm ^* Bu kişi benim
Türkiye

Yayımlanma Tarihi

1 Eylül 2019

Gönderilme Tarihi

3 Mart 2019

Kabul Tarihi

3 Mayıs 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 26 Sayı: 3

DOI

https://doi.org/10.17343/sdutfd.535002

IZ

https://izlik.org/JA43ET35NK

Kaynak Göster

RIS / Bibtex

APA

Aydın Acar, Ç., Çetin, Z., Yücel, O. K., Iltar, U., Salim, O., & Berker Karaüzüm, S. (2019). Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi. Medical Journal of Süleyman Demirel University, 26(3), 320-327. https://doi.org/10.17343/sdutfd.535002

AMA

1.Aydın Acar Ç, Çetin Z, Yücel OK, Iltar U, Salim O, Berker Karaüzüm S. Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi. SDÜ Tıp Fak Derg. 2019;26(3):320-327. doi:10.17343/sdutfd.535002

Chicago

Aydın Acar, Çiğdem, Zafer Çetin, Orhan Kemal Yücel, Utku Iltar, Ozan Salim, ve Sibel Berker Karaüzüm. 2019. “Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi”. Medical Journal of Süleyman Demirel University 26 (3): 320-27. https://doi.org/10.17343/sdutfd.535002.

EndNote

Aydın Acar Ç, Çetin Z, Yücel OK, Iltar U, Salim O, Berker Karaüzüm S (01 Eylül 2019) Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi. Medical Journal of Süleyman Demirel University 26 3 320–327.

IEEE

[1]Ç. Aydın Acar, Z. Çetin, O. K. Yücel, U. Iltar, O. Salim, ve S. Berker Karaüzüm, “Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi”, SDÜ Tıp Fak Derg, c. 26, sy 3, ss. 320–327, Eyl. 2019, doi: 10.17343/sdutfd.535002.

ISNAD

Aydın Acar, Çiğdem - Çetin, Zafer - Yücel, Orhan Kemal - Iltar, Utku - Salim, Ozan - Berker Karaüzüm, Sibel. “Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi”. Medical Journal of Süleyman Demirel University 26/3 (01 Eylül 2019): 320-327. https://doi.org/10.17343/sdutfd.535002.

JAMA

1.Aydın Acar Ç, Çetin Z, Yücel OK, Iltar U, Salim O, Berker Karaüzüm S. Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi. SDÜ Tıp Fak Derg. 2019;26:320–327.

MLA

Aydın Acar, Çiğdem, vd. “Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi”. Medical Journal of Süleyman Demirel University, c. 26, sy 3, Eylül 2019, ss. 320-7, doi:10.17343/sdutfd.535002.

Vancouver

1.Çiğdem Aydın Acar, Zafer Çetin, Orhan Kemal Yücel, Utku Iltar, Ozan Salim, Sibel Berker Karaüzüm. Kronik Myeloid Lösemide Tanı Anında İlave Kromozomal Abnormaliteler ve Varyant Philadephia Translokasyonları; Tek Merkez Deneyimi. SDÜ Tıp Fak Derg. 01 Eylül 2019;26(3):320-7. doi:10.17343/sdutfd.535002