MEZENKİMAL KÖK HÜCRE VE KOŞULLANDIRILMIŞ BESİYERİNİN OVARYUM HASARI ÜZERİNDEKİ TEDAVİ EDİCİ ETKİLERİ

Öz

Yapılan pek çok yeni çalışmada, mezenkimal kök hücrelerin (MSC) farklı hastalık modellerinde terapötik etkileri gösterilmiştir. İnfertilite, yaygınlığı yüksek küresel bir hastalık olup erkek faktörü, azalmış over rezervi, ovulatuar faktör, tubal faktör, uterin faktör, pelvik faktör ve açıklanamayan infertilite nedeniyle ortaya çıkabilir. MSC'lerin, farklılaşma kapasiteleri ve parakrin etki özellikleri nedeniyle, ovaryan yetmezlik tedavisindeki etkilerini belirlemek için birçok çalışma yapılmıştır. Araştırmalarda farklı kaynaklardan elde edilen MSC'lerin germ hücrelerine farklılaşma kapasiteleri in vitro’da belirlenirken over nişi üzerindeki etkileri MSC'lerin transplantasyonu ile belirlenmiştir. Bu derlemede, ovaryum hasarına bağlı gelişen ovaryan yetmezlik sebeplerini ele alarak, MSC'lerin ve koşullandırılmış besiyerinin ovaryum hasarı üzerindeki terapötik etkilerini belirlemek için mevcut çalışmaları özetledik.

Anahtar Kelimeler

• Kadın İnfertilitesi,Ovaryum Hasarı,Prematür Ovaryan Yetmezlik,Mezenkimal Kök Hücre,Koşullandırılmış Besiyeri

THERAPEUTIC EFFECTS OF MESENCHYMAL STEM CELL AND CONDITIONED MEDIUM ON OVARIAN DAMAGE

Öz

Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. Infertility is a global disease with high prevalence and may be caused by male factor, decreased ovarian reserve, ovulatory factor, tubal factor, uterine factor, pelvic factor and unexplained infertility. Many studies have been conducted to determine the effects of MSCs in the treatment of ovarian insufficiency due to their differentiation capacity and paracrine effects. The differentiation capacities of MSCs obtained from different sources to germ cells were determined in vitro and their effects on ovarian niche were determined by transplantation of MSCs. In this review, we discuss the causes of ovarian insufficiency due to ovarian damage and summarize the current studies to determine the therapeutic effects of MSCs and conditioned media on ovarian damage.

Anahtar Kelimeler

• Female İnfertility,Ovarian Damage,Premature Ovarian Failure,Mesenchymal Stem Cell,Conditioned Medium

Kaynakça

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