HASHİMOTO TİROİDİTLİ HASTALARDA ATEROSKLEROZ İLE İLİŞKİLİ PARAMETRELERİN DEĞERLENDİRİLMESİ

Year 2021, , 449 - 454, 13.09.2021

Hakan Yücel Suzan Tabur , Sadettin Öztürk Mustafa Araz Hale Çolakoğlu Er , Ertan Vuruskan

https://doi.org/10.17343/sdutfd.866770

Abstract

Amaç
Hashimoto tiroiditi otoimmün tiroid hastalığıdır. Aterosklerozda
arterlerin subintima tabakasında lipidler,
karbonhidratlar, fibröz doku, kalsiyum gibi maddelerin
lokal birikimlerinin oluşturduğu patolojik bir durum
söz konusudur. Vasküler endotelyal büyüme faktör
(VEGF) özellikle hipoksi varlığında seçici olarak endotel
hücrelerinde mitojenik etki ile damar gelişimini
uyararak yeni damar oluşumunda yaşamsal rol oynar.
Biz bu çalışmamızda ötiroid hashimoto hastalarında
serum VEGF düzeyi ile akım aracılı dilatasyon
(flow-mediated dilation, FMD) ve karotis intima media
kalınlığı (KİMK) ölçümü yaparak, otoimmünitenin tiroid
hastalarında ateroskleroz ile ilişkisini ortaya koymayı
amaçladık.
Gereç ve Yöntem
Gaziantep Üniversitesi Tıp Fakültesi Dahiliye Kliniği’nde
Hashimoto tiroiditi tanısı almış 40 hasta ile yaş
ve cinsiyet uyumlu 40 sağlıklı gönüllü çalışmaya dahil
edildi. Serum örneklerinde VEGF düzeyleri ELISA
yöntemiyle ölçüldü. Hasta ve kontrol grubunda ultrason
eşliğinde KİMK ve FMD değerlendirilerek mevcut
sonuçlarla ilişkili olup olmadığı tespit edildi.
Bulgular
Hasta ve kontrol grubunun demografik özellikleri benzerdi.
Hasta ve kontrol grupları arasında FMD ve
KIMK ölçümleri karşılaştırıldığında istatiksel olarak
anlamlı fark saptandı (p=0,001; p=0,033). VEGF düzeyinin
de hasta grubunda kontrol grubuna göre anlamlı
olarak yüksek olduğu tespit edildi (p=0,024).
Sonuç
Tüm bu sonuçlar tiroid hormon eksikliği olmadan da
otoimmüniteye sekonder ateroskleroz gelişebileceğini
ve hashimoto hastalarının erken dönem takiplerinde
noninvaziv uygulanabilen FMD, KİMK ölçümlerinin ve
VEGF düzeylerinin prediktif değerinin olabileceğini
göstermektedir.

Keywords

Hashimoto tiroiditi, Ateroskleroz, VEGF, KİMT, FMD

Supporting Institution

GAZİANTEP ÜNİVERSİTESİ BAP

Project Number

TF.UT.17.44

THE EVALUATION OF ATHEROSCLEROSIS RELATED PARAMETERS IN PATIENTS WITH HASHIMOTO’S THYROIDITIS

Abstract

Objective
Hashimoto thyroiditis is an autoimmune thyroid
disease. Atherosclerosis is a pathological condition
characterized by local accumulation of substances
such as lipids, carbohydrates, fibrous tissue and
calcium in the subintima layer of arteries. In this
study, we aimed to reveal the relationship between
autoimmunity and atherosclerosis by measuring
serum VEGF levels, flow-mediated dilation (FMD)
and carotid intima-media thicknes (CIMT) in euthyroid
patients with Hashimoto thyroiditis.
Materials and Methods
Forty patients diagnosed with Hashimoto thyroiditis in
the Internal Medicine Clinic of Gaziantep University
Medical Faculty and 40 healthy volunteers matched
for age and gender were included in the study.
VEGF levels were measured by ELISA method in
serum samples. CIMT and FMD were evaluated
with ultrasound guidance in the patient and control
groups and it was determined whether there was a
association with the present results.
Results
The demographic characteristics of the patient and
control groups were similar. There was a significant
difference between the patients and healthy control
group in terms of FMD and CIMC measurements (p =
0.001; p = 0.033). It was also found that VEGF levels
of patients were higher than those in the control group
(p = 0.024).
Conclusion
All these results show autoimmunity may lead
atherosclerosis even without thyroid hormone
deficiency and also noninvasive FMD, CIMT
measurements and VEGF levels may have predictive
value in the early follow-up of Hashimoto patients.

Keywords

Atherosclerosis, VEGF, CIMT, FMD, Hashimoto

Project Number

TF.UT.17.44

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