DETERMINATION OF THE RELATIONSHIP BETWEEN ANGIOTENSIN I-CONVERTING ENZYME GENE POLYMORPHISM AND VO2MAX LEVELS AND ATHLETIC PERFORMANCE IN ELITE TURKISH WRESTLERS

Abstract

The polymorphism of angiotensin I-converting enzyme gene is one of the important genes associated with physical activity, The aim of this study is to determine whether there is a relationship between ACE I/D gene polymorphism and athletic performance and genotype distribution of the ACE gene and maximum oxygen consumption (Vo2max) in the elite Turkish wrestlers. ACE I/D gene polymorphism is investigated in 46 elite Turkish wrestlers and 58 healthy sedentary individuals. Vo2max values in elite wrestlers were measured by a progressive shuttle run test. DNA of elite wrestlers and sedentary individuals was obtained from peripheral blood. The allele frequencies and genotype distribution of ACE I/D gene polymorphism determined by polymerase chain reaction. Allele frequencies and genotype distribution of ACE I/D gene polymorphism in the elite wrestlers and sedentary individuals were compared and no significant difference was found between elite wrestlers and sedentary individuals (P>0.05). There was also no difference between the genotype distribution of the ACE I/D gene polymorphism and Vo2max levels in the elite wrestlers  (P>0.05). It was determined that Vo2max showed similar distribution in elite wrestlers with DD, ID and II genotypes. The present study demonstrated that there was no significant relationship between the ACE I/D gene polymorphism and sports performance and genotypes of ACE I/D gene polymorphism and Vo2max in elite Turkish wrestlers.

Keywords

• Angiotensin Converting Enzyme,Athletic Performance,Wrestling,Polymorphism,Vo2max

ELİT TÜRK GÜREŞÇİLERİNİN ANJİOTENSİN I-DÖNÜŞTÜRÜCÜ ENZİM GEN POLİMORFİZMİ VE VO2MAX DÜZEYLERİ İLE ATLETİK PERFORMANS ARASINDAKİ İLİŞKİNİN BELİRLENMESİ

Öz

Anjiotensin I-dönüştürücü enzim gen polimorfizmi fiziksel aktivite ile ilişkili önemli genlerden biridir. Bu çalışmanın amacı, elit Türk güreşçilerde ADE I/D gen polimorfizmi ile atletik performans ve ADE geni genotip dağılımı ile maksimum oksijen tüketimi (Vo2max) arasında bir ilişki olup olmadığını belirlemektir. ADE I/D gen polimorfizmi 46 elit Türk güreşçi ve 58 sağlıklı sedanter bireyde araştırıldı. Elit güreşçilerin Vo2max değerleri mekik koşu testi ile ölçüldü. Elit güreşçi ve sedanter bireylerin DNA’sı periferal kandan elde edildi. ADE I/D gen polimorfizmi alel frekansları ve genotip dağılımı polimeraz zincir reaksiyonu ile belirlendi. Elit güreşçi ve sedanter bireylerin ACE I/D gen polimorfizmi alel frekansları ve genotip dağılımı karşılaştırıldı ve elit güreşçi ve sedanter bireyler arasında önemli bir fark bulunmadı (P>0.05). Elit güreşçilerin ADE I/D gen polimorfizmi genotip dağılımı ile Vo2max düzeyleri arasında bir fark tespit edilmedi (P>0.05). Vo2max düzeylerinin DD, ID ve II genotipli elit güreşçilerde benzer dağılım gösterdiği belirlendi. Bu araştırma elit Türk güreşçilerinde ADE I/D gen polimorfizmi ile spor performansı ve ACE I/D gen polimorfizmi genotipleri ile Vo2max arasında anlamlı bir ilişki olmadığını göstermiştir.  

Anahtar Kelimeler

• Anjiotensin dönüştürücü enzim,Atletik Performans,Güreş,Polimorfizm,Vo2max

Kaynakça

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