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Beyin Omurilik Sıvısında Polimeraz Zincir Reaksiyonu İle Tanı Alan Konjenital Toksoplazmozisli Bir Yenidoğan Olgusu

Yıl 2013, Özel Sayı, 53 - 56, 01.06.2013

Öz

Konjenital toksoplazmozis gebelikte geçirilen akut enfeksiyonun fetusa geçmesiyle oluşan nadir bir enfeksiyondur. Hastalık, yenidoğanlarda serolojik olarak saptanan hafif formdan, koryoretinit, menenjit, hidrosefali ve intrakraniyal kalsifikasyonlar gösteren ağır forma kadar geniş bir spektrum içinde kendini gösterebilir. Bu makalede, prenatal ultrasonografide lateral ventrikülde genişleme saptanan ancak postnatal geç dönemde menenjitle ortaya çıkan, serolojik testler negatif olmasına rağmen beyin omurilik sıvısı polimeraz zincir reaksiyonu testi ile tanı konulan fatal seyirli konjenital toksoplazmozisli bir olgu sunulmaktadır.

Kaynakça

  • Carter AO, Frank JW. Congenital toxoplasmosis: Epidemiologic features and control. CMAJ 1986;135:618-32.
  • Uludağ S, Madazlı R, Şen C, Ocak V. Gebelik ve toksoplazmozisde klinik yönetim. Perinatoloji Dergisi 1993;1:165-9.
  • Desmont G, Couvreur J. Congenital toxoplasmosis: A prospective study of the offspring of 542 women who acquired toxoplasmosis during pregnancy pathophysiology of congenital disease. Perinatal Medi 1979;51-7.
  • Mandell GL, Benett JE, Dolin R. Principles and practice of infectious diseases. In: Montoya JG, Kovacs JA, Remington JS (eds). Toxoplasma gondii. 6th ed. Newyork: Churchill Livingstone, 2005;2:3170-228.
  • Magi B, Migliorini L. Western blotting for the diagnosis of congenital toxoplasmosis. New Microbiol 2011;34:93-5.
  • 6. SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group, Thiébaut R, Leproust S, Chêne G, Gilbert R. Effectiveness of prenatal treatment for congenital toxoplasmosis: A meta-analysis of individual patients’ data. Lancet 2007; 369:115- 22.
  • 7. Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 2008;47:554-66. 8. Wong SY, Remington JS. Toxoplasmosis in pregnancy. Clin Infect Dis 1994;18:853-61.
  • 9. Cazenaye J, Forestier F, Bessieres MH, Broussin B, Begueret J. Contribution of a new PCR assay to the prenatal diagnosis of congenital toxoplasmosis. Prenat Diagn 1992;12:119-27.
  • 10. Hohlfeld P, Daffos F, Costa JM, Thulliez P, Forestier F, Vidaud M. Prenatal diagnosis of congenital toxoplasmosis with a polymerasechain reaction test on amniotic fluid. N Engl J Med 1994;331:695- 9.
  • 11. Wigglesworth JS, Singer DB. Textbook of fetal and perinatal pathology. In: Singer DB (ed). Infections of Fetuses and Neonates. 2nd ed. Boston: Blackwell, 1991:1:574-6.
  • 12. Gupta K, Vasishta RK, Bansal A, Khadwal A, Khurana S, Sodhi KS. Cortical cysts with hydrocephalus and ventriculitis: An unusual presentation of congenital toxoplasmosis at autopsy. J Clin Pathol 2011;64:272-4.
  • 13. Said RN, Zaki MM, Abdelrazik MB. Congenital toxoplasmosis: evaluation of molecular and serological methods for achieving economic and early diagnosis among egyptian preterm ınfants. J Trop Pediatr 2011;57:333-9.
  • 14. Fioretti DP. Problems and limitations of conventional and innovative methods for the diagnosis of Toxoplasmosis in humans and animals. Parassitologia 2004;46:177-81.
  • 15. Sterkers Y, Ribot J, Albaba S, Issert E, Bastien P, Pratlong F. Diagnosis of congenital toxoplasmosis by polymerase chain reaction on neonatal peripheral blood. Diagn Microbiol Infect Dis 2011;71:174-6.
  • 16. Olariu TR, Remington JS, McLeod R, Alam A, Montoya JG. Severe congenital toxoplasmosis in the united States Clinical and serologic findings in untreated infants. Pediatr Infect Dis J 2011;30: 1056- 61.
  • 17. Nagaty IM, Ibrahim KM, Abdel-Tawab AH, Hassan AE. Diagnosis of Toxoplasma gondii by ELISA and PCR in mothers and their infants. J Egypt Soc Parasitol 2009;39:625-32.

A Newborn with Congenital Toxoplasmosis Diagnosed by Cerebrospinal Fluid Polymerase Chain Reaction

Yıl 2013, Özel Sayı, 53 - 56, 01.06.2013

Öz

Congenital toxoplasmosis is a rare infection transmitted to the fetus from an acutely infected mother during the pregnancy. In neonates, the disease has a broad spectrum ranging from a mild form that can only be serologically detected to a severe form that presents with chorioretinitis, meningitis, hydrocephalus, and intracranial calcifications. In this article, we report a fatal case of congenital toxoplasmosis that presented with meningitis at the late postnatal period. Although prenatal ultrasonography showed dilatation of lateral ventricles, the serological tests were negative during the postnatal period and the patient was diagnosed to have toxoplasmosis with the cerebrospinal fluid polymerase chain reaction

Kaynakça

  • Carter AO, Frank JW. Congenital toxoplasmosis: Epidemiologic features and control. CMAJ 1986;135:618-32.
  • Uludağ S, Madazlı R, Şen C, Ocak V. Gebelik ve toksoplazmozisde klinik yönetim. Perinatoloji Dergisi 1993;1:165-9.
  • Desmont G, Couvreur J. Congenital toxoplasmosis: A prospective study of the offspring of 542 women who acquired toxoplasmosis during pregnancy pathophysiology of congenital disease. Perinatal Medi 1979;51-7.
  • Mandell GL, Benett JE, Dolin R. Principles and practice of infectious diseases. In: Montoya JG, Kovacs JA, Remington JS (eds). Toxoplasma gondii. 6th ed. Newyork: Churchill Livingstone, 2005;2:3170-228.
  • Magi B, Migliorini L. Western blotting for the diagnosis of congenital toxoplasmosis. New Microbiol 2011;34:93-5.
  • 6. SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group, Thiébaut R, Leproust S, Chêne G, Gilbert R. Effectiveness of prenatal treatment for congenital toxoplasmosis: A meta-analysis of individual patients’ data. Lancet 2007; 369:115- 22.
  • 7. Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 2008;47:554-66. 8. Wong SY, Remington JS. Toxoplasmosis in pregnancy. Clin Infect Dis 1994;18:853-61.
  • 9. Cazenaye J, Forestier F, Bessieres MH, Broussin B, Begueret J. Contribution of a new PCR assay to the prenatal diagnosis of congenital toxoplasmosis. Prenat Diagn 1992;12:119-27.
  • 10. Hohlfeld P, Daffos F, Costa JM, Thulliez P, Forestier F, Vidaud M. Prenatal diagnosis of congenital toxoplasmosis with a polymerasechain reaction test on amniotic fluid. N Engl J Med 1994;331:695- 9.
  • 11. Wigglesworth JS, Singer DB. Textbook of fetal and perinatal pathology. In: Singer DB (ed). Infections of Fetuses and Neonates. 2nd ed. Boston: Blackwell, 1991:1:574-6.
  • 12. Gupta K, Vasishta RK, Bansal A, Khadwal A, Khurana S, Sodhi KS. Cortical cysts with hydrocephalus and ventriculitis: An unusual presentation of congenital toxoplasmosis at autopsy. J Clin Pathol 2011;64:272-4.
  • 13. Said RN, Zaki MM, Abdelrazik MB. Congenital toxoplasmosis: evaluation of molecular and serological methods for achieving economic and early diagnosis among egyptian preterm ınfants. J Trop Pediatr 2011;57:333-9.
  • 14. Fioretti DP. Problems and limitations of conventional and innovative methods for the diagnosis of Toxoplasmosis in humans and animals. Parassitologia 2004;46:177-81.
  • 15. Sterkers Y, Ribot J, Albaba S, Issert E, Bastien P, Pratlong F. Diagnosis of congenital toxoplasmosis by polymerase chain reaction on neonatal peripheral blood. Diagn Microbiol Infect Dis 2011;71:174-6.
  • 16. Olariu TR, Remington JS, McLeod R, Alam A, Montoya JG. Severe congenital toxoplasmosis in the united States Clinical and serologic findings in untreated infants. Pediatr Infect Dis J 2011;30: 1056- 61.
  • 17. Nagaty IM, Ibrahim KM, Abdel-Tawab AH, Hassan AE. Diagnosis of Toxoplasma gondii by ELISA and PCR in mothers and their infants. J Egypt Soc Parasitol 2009;39:625-32.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA83NN36FC
Bölüm Case Report
Yazarlar

Banu Aydın Bu kişi benim

Dilek Dilli Bu kişi benim

Ayşegül Zenciroğlu Bu kişi benim

Nuran Uzunalıç Bu kişi benim

Nurullah Okumuş Bu kişi benim

Gökçe Çınar Bu kişi benim

Mustafa Aydın Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2013
Gönderilme Tarihi 1 Haziran 2013
Yayımlandığı Sayı Yıl 2013 Özel Sayı

Kaynak Göster

Vancouver Aydın B, Dilli D, Zenciroğlu A, Uzunalıç N, Okumuş N, Çınar G, Aydın M. A Newborn with Congenital Toxoplasmosis Diagnosed by Cerebrospinal Fluid Polymerase Chain Reaction. Türkiye Çocuk Hast Derg. 2013;7(1,EK):53-6.

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