Evaluation of benzaldehyde derivatives as being bovine kidney aldose reductase inhibitors

Yıl 2023, , 61 - 67, 22.06.2023

Bülent Şengül

https://doi.org/10.46810/tdfd.1204055

Cited By: 2

Bu makale için 28 Aralık 2023 tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/tdfd/issue/81944/1411956

Öz

Aldoz redüktaz (AR), poliol yolunda glikozdan sorbitol üretimini katalize eder ve insülinden bağımsız dokularda anormal sorbitol agregasyonuna neden olan, retinopati, nöropati ve nefropati gibi bazı problemler yaratan kritik bir enzimdir. AR inhibisyonunun bu yan etkileri azaltmak için uygun bir yaklaşım olduğu gösterilmiştir. Mevcut çalışma, literatüre yeni AR inhibitörlerini tanıtmayı amaçlamıştır. Bu amaçla AR inhibitörleri olarak benzaldehitler incelenmiştir. İlk olarak sığır böbreğinden homojenat hazırlanmış, ardından inhibisyon çalışmaları yapılmıştır. Çalışılan bütün benzaldehit türevlerinin AR'yi inhibe ettiği bulundu. 0.23 ve 1.37 µM IC50 değerlerine sahip olan türev 3 ve 6'nın inhibitör aktivitesi, standart inhibitör sorbinilden daha yüksek olduğu tespit edildi. In vitro inhibisyon çalışmalarından sonra, tahmini bağlanma enerjileri ve türevlerin enzime bağlanma modları moleküler docking ile tahmin edildi. Bileşik 3, -8,61 kcal/mol'lük bir maksimum yerleştirme puanı sergiledi. Sonuç olarak, bu bileşikler, özellikle bileşik 3, diyabetik komplikasyonların tedavisinde veya önlenmesinde yeni ilaç aday moleküllerinin sentezi için yol gösterici moleküller olabilir.

Anahtar Kelimeler

Inhibition, molecular docking, polyol pathway, benzaldehydes

Kaynakça

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