Yıl 2024,
, 176 - 188, 26.03.2024
Giyasettin Baydaş
,
Fatma Tutku Aksoy
,
Zeynep Güngördü Dalar
,
Merve Nur Aksakal
,
İpek Çoruhlu
,
Sara Çıbık
,
Elif Sena Ozcan
,
Öykü Toptaş
,
Zümra Kul
Kaynakça
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- Türk Gıda Kodeksi Bal Tebliği. T.C. Resmi Gazete, Sayı: 31107, 22 Nisan 2020.
- Karadal F, Yıldırım Y. Balın kalite nitelikleri, beslenme ve sağlık açısından önemi. Erciyes Üniv Vet Fak Derg. 2012; 9(3):197-209.
- Bogdanov S. Honey composition. The Honey Book. 2009; p. 1-9.
- Özkök A, D’arcy B, Sorkun K. Total phenolic acid and total flavonoid content of Turkish pine honeydew honey. JAAS. 2010; 2(2): 65-71.
- Viuda‐Martos M, Ruiz‐Navajas Y, Fernández‐López J, Pérez‐Álvarez JA. Functional properties of honey, propolis, and royal jelly. J Food Sci. 2008; 73(9): R117-R124.
- Aksoy Z, Dığrak M. Bingöl yöresinde toplanan bal ve propolisin antimikrobiyal etkisi üzerinde in vitro araştırmalar. Fırat Üniv Fen Müh Bilim Derg. 2006; 18(4): 471-8.
- White JW. Subers MH, Schepartz AI. The identification of inhibine the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucose-oxidase system. Biochem Biophys Acta. 1963; 73(1): 57-70.
- Alvarez-Suarez JM, Giampieri F, Battino M. Honey as a source of dietary antioxidants: Structures, bioavailability, and evidence of protective effects against human chronic diseases. Curr Med Chem. 2013; 20(5): 621-38.
- Ajibola A, Chamunorwa JP, Erlwanger KH. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutr Metab. 2012; 9(61): 1-13.
- Koca I, Koca AF. Poisoning by mad honey: a brief review. Food Chem Toxicol. 2007; 45(8): 1315-1318.
- Aureli P, Franciosa G, Fenicia L. Infant botulism and honey in Europe: a commentary. Pedıatr Infect Dıs J. 2002; 21(9): 866-868
- Sforcin JM, Bankova V. Propolis: is there a potential for the development of new drugs? J Ethnopharmacol. 2011; 133(2): 253-260.
- Krell R. Value-Added Products from Beekeeping, Fao Agricultural Services Bulletin No. 124, Chapter 3, Pollen;1996.
- Bankova VS, de Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie. 2000; 31(1): 3-15.
- Bogdanov S. Propolis: biological properties and medical applications. The propolis book. Chapter 2. 2012; p. 1-42.
- Marcucci MC. Propolis: Chemical composition, biological properties and therapeutic activity. Apidologie. 1995; 26: 83–99.
- Yang H, Huang Z, Huang Y, Dong W, Pan Z, Wang L. Characterization of Chinese crude propolis by pyrolysis–gas chromatography/mass spectrometry. JAAP. 2015; 113: 158-164.
- Piccinelli AL, Mencherini T, Celano R, Mouhoubi Z, Tamendjari A, Aquino RP et al. Chemical composition and antioxidant activity of Algerian propolis. J. Agric. Food Chem 2013; 61(21): 5080-5088.
- Moura, SALD, Negri G, Salatino A, Lima LDDC, Dourado LPA, Mendes JB, et al. Aqueous extract of Brazilian green propolis: primary components, evaluation of inflammation and wound healing by using subcutaneous implanted sponges. Evidence-Based Complementary and Alternative Medicine. 2011; 8:1-9.
- Franchin M, Colon DF, Castanheira FV, daCunha MG, Bueno-Silva,B, Alencar SM, Rosalen, PL. Vestitol isolated from Brazilian red propolis inhibits neutrophils migration in the inflammatory process: elucidation of the mechanism of action. J. Nat. Prod. 2016; 79(4): 954-960.
- Kang LJ, Lee HB, Bae HJ, Lee SG. Antidiabetic effect of propolis: reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3α/β in HepG2 cells. Phytother Res. 2010; 24(10): 1554-1561.
- Darendelioglu E, Aykutoglua G, Tartik M, Baydas G. Turkish propolis protects human endothelial cells in vitro from homocysteine-induced apoptosis. Acta Histochem. 2016; 118, (4), 369-376,
- De Castro PA, Savoldi M, Bonatto D, Malavazi I, Goldman MHS, Berretta AA, et al. Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis. BMC Complement Altern Med. 2012; 12: 1-14.
- Tartik M, Darendelioglu E, Aykutoglu G, Baydas G. Turkish propolis supresses MCF-7 cell death induced by homocysteine. Biomed Pharmacother. 2016; 82: 704-712
- Basavaiah ND, Suryakanth DB. Propolis and allergic reactions. J Pharm Bioallied Sci. 2012; 4(4): 345.
- de Groot AC. Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis, 2013; 24(6): 263-82.
- Silici S, Okan A, Köklü B, Demiray S, Doğanyiğit Z. Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats. Z Geburtshilfe Neonatol. 2023; 227(4): 261-268.
- Wang X, Wang Z, Di S, Xue X, Jin Y, Qi P, et al. Determination of 14 lipophilic pesticide residues in raw propolis by selective sample preparation and gas chromatography–tandem mass spectrometry. Food Anal. Methods. 2020; 13: 1726–1735.
- Végh R, Csóka M, Mednyánszky Z, Sipos L. Pesticide residues in bee bread, propolis, beeswax and royal jelly- A review of the literature and dietary risk assessment. Food Chem Toxicol. 2023; 176: 113806.
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis. 2020; 29(3): 468-469.
- Pasupuleti V.R. Sammugam L. Ramesh N. Gan S.H. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev, 2017, 1259510.
- Silici S. Honeybee Products and Apitherapy. Turk J Food Agric Sci. 2019; 7(9): 1249-1262.
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BEE PRDUCTS AND THE POTENTIAL HEALTH ISSUES ARISING FROM THEIR UNCONTROLLED USE
Yıl 2024,
, 176 - 188, 26.03.2024
Giyasettin Baydaş
,
Fatma Tutku Aksoy
,
Zeynep Güngördü Dalar
,
Merve Nur Aksakal
,
İpek Çoruhlu
,
Sara Çıbık
,
Elif Sena Ozcan
,
Öykü Toptaş
,
Zümra Kul
Öz
In Turkiye, as well as worldwide, traditional and alternative medical practices are employed for the preservation of health and the treatment of various diseases. Among these practices, Apitherapy has gained particular attention, especially in recent years. Since drug use causes serious side effects, especially on human health, people are increasingly turning to alternative medical treatment methods with minimal or no side effects.
Apitherapy is a treatment method involving bee products such as honey, pollen, Royal Jel, propolis, and bee venom. It is primarily used for the purpose of promoting a healthier lifestyle. While these products have been traditionally used in various treatments for many years, their systematic use has gained prominence in recent years. Studies have shown that these products strengthen the immune system, provide protection against various types of cancer, and exhibit antimicrobial and antioxidant properties.
Furthermore, the high content of protein, vitamins, minerals, and amino acids in these products enhances their therapeutic potential. However, alongside the benefits of these supportive and therapeutic substances, there is a possibility of various toxic effects when used irregularly and without medical supervision. Sometimes, these situations can lead to various organ failures. This review aims to reveal the undesirable effects encountered in the use of bee products and apitherapy applications, and emphasizes that all natural products, especially bee products, should not be used uncontrolled.
Kaynakça
- Karabagias IK, Badeka AV, Kontakos S, Karabournioti S, Kontominas MG. Botanical discrimination of Greek unifloral honeys with physico-chemical and chemometric analyses. Food Chem. 2014; 165: 181-190.
- Türk Gıda Kodeksi Bal Tebliği. T.C. Resmi Gazete, Sayı: 31107, 22 Nisan 2020.
- Karadal F, Yıldırım Y. Balın kalite nitelikleri, beslenme ve sağlık açısından önemi. Erciyes Üniv Vet Fak Derg. 2012; 9(3):197-209.
- Bogdanov S. Honey composition. The Honey Book. 2009; p. 1-9.
- Özkök A, D’arcy B, Sorkun K. Total phenolic acid and total flavonoid content of Turkish pine honeydew honey. JAAS. 2010; 2(2): 65-71.
- Viuda‐Martos M, Ruiz‐Navajas Y, Fernández‐López J, Pérez‐Álvarez JA. Functional properties of honey, propolis, and royal jelly. J Food Sci. 2008; 73(9): R117-R124.
- Aksoy Z, Dığrak M. Bingöl yöresinde toplanan bal ve propolisin antimikrobiyal etkisi üzerinde in vitro araştırmalar. Fırat Üniv Fen Müh Bilim Derg. 2006; 18(4): 471-8.
- White JW. Subers MH, Schepartz AI. The identification of inhibine the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucose-oxidase system. Biochem Biophys Acta. 1963; 73(1): 57-70.
- Alvarez-Suarez JM, Giampieri F, Battino M. Honey as a source of dietary antioxidants: Structures, bioavailability, and evidence of protective effects against human chronic diseases. Curr Med Chem. 2013; 20(5): 621-38.
- Ajibola A, Chamunorwa JP, Erlwanger KH. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutr Metab. 2012; 9(61): 1-13.
- Koca I, Koca AF. Poisoning by mad honey: a brief review. Food Chem Toxicol. 2007; 45(8): 1315-1318.
- Aureli P, Franciosa G, Fenicia L. Infant botulism and honey in Europe: a commentary. Pedıatr Infect Dıs J. 2002; 21(9): 866-868
- Sforcin JM, Bankova V. Propolis: is there a potential for the development of new drugs? J Ethnopharmacol. 2011; 133(2): 253-260.
- Krell R. Value-Added Products from Beekeeping, Fao Agricultural Services Bulletin No. 124, Chapter 3, Pollen;1996.
- Bankova VS, de Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie. 2000; 31(1): 3-15.
- Bogdanov S. Propolis: biological properties and medical applications. The propolis book. Chapter 2. 2012; p. 1-42.
- Marcucci MC. Propolis: Chemical composition, biological properties and therapeutic activity. Apidologie. 1995; 26: 83–99.
- Yang H, Huang Z, Huang Y, Dong W, Pan Z, Wang L. Characterization of Chinese crude propolis by pyrolysis–gas chromatography/mass spectrometry. JAAP. 2015; 113: 158-164.
- Piccinelli AL, Mencherini T, Celano R, Mouhoubi Z, Tamendjari A, Aquino RP et al. Chemical composition and antioxidant activity of Algerian propolis. J. Agric. Food Chem 2013; 61(21): 5080-5088.
- Moura, SALD, Negri G, Salatino A, Lima LDDC, Dourado LPA, Mendes JB, et al. Aqueous extract of Brazilian green propolis: primary components, evaluation of inflammation and wound healing by using subcutaneous implanted sponges. Evidence-Based Complementary and Alternative Medicine. 2011; 8:1-9.
- Franchin M, Colon DF, Castanheira FV, daCunha MG, Bueno-Silva,B, Alencar SM, Rosalen, PL. Vestitol isolated from Brazilian red propolis inhibits neutrophils migration in the inflammatory process: elucidation of the mechanism of action. J. Nat. Prod. 2016; 79(4): 954-960.
- Kang LJ, Lee HB, Bae HJ, Lee SG. Antidiabetic effect of propolis: reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3α/β in HepG2 cells. Phytother Res. 2010; 24(10): 1554-1561.
- Darendelioglu E, Aykutoglua G, Tartik M, Baydas G. Turkish propolis protects human endothelial cells in vitro from homocysteine-induced apoptosis. Acta Histochem. 2016; 118, (4), 369-376,
- De Castro PA, Savoldi M, Bonatto D, Malavazi I, Goldman MHS, Berretta AA, et al. Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis. BMC Complement Altern Med. 2012; 12: 1-14.
- Tartik M, Darendelioglu E, Aykutoglu G, Baydas G. Turkish propolis supresses MCF-7 cell death induced by homocysteine. Biomed Pharmacother. 2016; 82: 704-712
- Basavaiah ND, Suryakanth DB. Propolis and allergic reactions. J Pharm Bioallied Sci. 2012; 4(4): 345.
- de Groot AC. Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis, 2013; 24(6): 263-82.
- Silici S, Okan A, Köklü B, Demiray S, Doğanyiğit Z. Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats. Z Geburtshilfe Neonatol. 2023; 227(4): 261-268.
- Wang X, Wang Z, Di S, Xue X, Jin Y, Qi P, et al. Determination of 14 lipophilic pesticide residues in raw propolis by selective sample preparation and gas chromatography–tandem mass spectrometry. Food Anal. Methods. 2020; 13: 1726–1735.
- Végh R, Csóka M, Mednyánszky Z, Sipos L. Pesticide residues in bee bread, propolis, beeswax and royal jelly- A review of the literature and dietary risk assessment. Food Chem Toxicol. 2023; 176: 113806.
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis. 2020; 29(3): 468-469.
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