MEME KANSERİNE BİTKİSEL TEDAVİ YÖNTEMİ: MOMORDİCA CHARANTİA'NIN ANTİTÜMÖR ETKİSİ

Yıl 2024, Cilt: 23 Sayı: 45, 144 - 155, 26.06.2024

Murat Ihlamur , Kübra Kelleci , Melisa Özkan , Emrah Şefik Abamor

https://doi.org/10.55071/ticaretfbd.1356139

Cited By: 1

Öz

Kanserde mevcut tedavi yöntemlerinin yan etkilerinden korunmak için bitki bazlı tedavi yaklaşımları ve bitkisel ilaçların kullanımı günümüzde dikkat çekmektedir. Literatüre göre acı kavun ekstraktı hormonal yolları etkileyerek kansere karşı sitotoksik etki göstermektedir. Bu nedenle bu araştırmada acı kavun ekstraktının farklı konsantrasyonlarda ilaç kombinasyonu ile farklı hücre hatlarına (MCF-7, MDA-MB-231, RAW 264.7, J774) karşı etkileri araştırıldı. Hem hormon pozitif hem de negatif meme kanseri hücre hatları kullanıldı ve elde edilen veriler literatürle karşılaştırıldı. Sonuç olarak; Acı kavun ekstraktına maruz bırakıldığında, hormon pozitif meme kanseri hücre dizisi MCF-7, üçlü hormon negatif meme kanseri hücre dizisi MDA-MBA-231 ile karşılaştırıldığında daha fazla sitotoksik etki sergiler. Kudret narı ekstraktı ile birlikte kullanılan ilaçların kombinasyonu için en yüksek sitotoksisite Tamoksifen ile gözlendi.

Anahtar Kelimeler

Momordica charantia, Meme Kanseri, Kanser tedavisi, Fitoterapi

A HERBAL TREATMENT METHOD FOR BREAST CANCER: ANTITUMOR EFFECT OF MOMORDICA CHARANTIA

Öz

Using plant-based treatment approaches and herbal medicines is getting attention these days to avoid the side effects of the current treatment methods for cancer. According to the literature, bitter melon extract exhibits cytotoxic effects against cancer by affecting the hormonal pathways. Therefore, in this research, the effects of the bitter melon extract with its combination of different concentrations of drugs were investigated against different cell lines (MCF-7, MDA-MB-231, RAW 264.7, J774). Both hormone-positive and negative breast cancer cell lines were used and the obtained data were compared with the literature. As a result, when exposed to bitter melon extract, the hormone-positive breast cancer cell line MCF-7 exhibits more cytotoxic effects compared to the triple hormone-negative breast cancer cell line MDA-MBA-231. For the combination of drugs along with the bitter melon extract; the highest cytotoxicity was observed with Tamoxifen.

Anahtar Kelimeler

Momordica charantia, Breast Cancer, Cancer treatment, Phytotherapy

Kaynakça

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