The effect of skeletal muscle density on survival in patients with early stage gastric cancer

Öz

Aim :Skeletal muscle wasting is closely correlated with the prognosis of patients diagnosed with gastric cancer. In our study, we aimed to investigate the effect of measuring skeletal muscle density with computed tomography on survival. Materials and Methods:A total of 62 patients were included in the study. Skeletal muscle density (HUAC) was measured. Univariate and multivaritecox regression analyzes were performed to determine the factors affecting survival. Results:A significant correlation was found between survival and stage, lymphovascular invasion, perineuralinvasion, and whether or not to receive adjuvant therapy. The survival of male and female patients with low HUAC values was significantly worse in both univariate and multivariate analysis. Conclusion:In our study, we demonstrated the independent association of preoperative HUAC measurement with survival in patients with early stage gastric cancer. Survival rates were found to be significantly lower in patients with low skeletal muscle density.

Anahtar Kelimeler

• gastric cancer
• sarcopenia
• skeletal muscle density

Erken evre mide kanserli hastalarda iskelet kas dansitesinin sağkalım üzerine etkisi

Öz

Amaç : İskelet kas kaybı mide kanseri tanısı almış hastaların prognozu ile yakın koreledir. Çalışmamızda iskelet kas dansitesinin bilgisayarlı tomografi ile ölçümünün sağkalım üzerine etkisini araştırmayı amaçladık. Gereç ve yöntemler: Çalışmaya toplam 62 hasta dahil edildi. İskelet kas dansitesi (HUAC) ölçümü yapıldı. Sağkalım üzerine etki eden faktörleri saptamak için ünivariate ve multivarite cox regresyon analizi yapıldı. Bulgular: Evre, lenfovasküler invazyon, perinöral invazyon ve adjuvan tedavi alıp almama durumu ile sağkalım arasında anlamlı ilişki saptandı. HUAC değeri düşük olan erkek ve kadın hastaların sağkalımları hem ünivariate hem de multivariate analizde anlamlı olarak kötü tesbit edildi. Sonuç: çalışmamızda erken evre mide kanserli hastalarda operasyon öncesi HUAC ölçümünün sağkalım ile bağımsız olarak ilişkisini gösterdik. İskelet kas dansitesi düşük olan hastalarda sağkalımlar anlamlı olarak düşük saptandı.

Anahtar Kelimeler

• mide kanseri,
• sarkopeni
• , iskelet kas dansitesi

Kaynakça

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