Mikozis fungoideste LDH/albumin oranının prognostik değeri: retrospektif olgu-kontrol çalışması

Öz

Amaç: Mycosis fungoides (MF), değişken klinik seyirli en yaygın primer kutanöz T hücreli lenfomadır. Güvenilir prognostik biyobelirteçlerin belirlenmesi, risk sınıflaması ve bireyselleştirilmiş hasta yönetimi açısından önemlidir. Bu çalışmada, LDH/albumin oranının (LAR) MF hastalarında ileri evre hastalığı öngörmedeki prognostik değerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Retrospektif olgu-kontrol çalışmasına 92 MF hastası ve 94 sağlıklı kontrol dahil edilmiştir. Klinik ve laboratuvar verileri elektronik kayıtlardan elde edilmiştir. LAR ve diğer inflamatuvar indeksler hesaplanmış; grup karşılaştırmaları ve ROC analizleri yapılmıştır. Bulgular: MF hastalarında LAR, LDH, CRP, ESR, CAR ve SII değerleri anlamlı olarak yüksek, albumin düzeyleri ise düşük bulunmuştur (p<0.05). LAR, klinik evre (r=0.614), LDH (r=0.956) ve albumin (r=−0.598) ile anlamlı korelasyon göstermiştir. ROC analizi, LAR’ın ileri evre hastalığı ayırt etmede en yüksek doğruluğa sahip olduğunu göstermiştir (AUC 0.877; %95 GA 0.816–0.939). Sonuç: LAR, MF’de ileri evre hastalığın belirlenmesinde umut verici, kolay erişilebilir bir biyobelirteçtir. Klinik değerlendirmelere LAR’ın dahil edilmesi, risk sınıflamasını geliştirebilir ve bireyselleştirilmiş tedavi yaklaşımlarına katkı sağlayabilir. Bulguların doğrulanması için ileriye dönük çok merkezli çalışmalar gereklidir.

Anahtar Kelimeler

• mikozis fungoides
• laktat dehidrogenaz
• serum albümin
• biyobelirteçler
• prognoz

Prognostic value of the LDH-to-albumin ratio in mycosis fungoides: a retrospective case–control study

Öz

Aim: Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma with a variable clinical course. This study aimed to evaluate the prognostic value of the lactate dehydrogenase-to-albumin ratio (LAR) in predicting advanced-stage disease in MF patients. Material and Methods: A retrospective case–control study included 92 patients with MF and 94 healthy controls. Clinical and laboratory data were collected from medical records. LAR and other inflammatory indices were calculated. Group comparisons and receiver operating characteristic (ROC) analyses were performed. Results: Patients with MF had significantly higher LAR, LDH, CRP, ESR, CAR, and SII values, and lower albumin levels than controls (p<0.05). LAR correlated positively with disease stage (r=0.614) and LDH (r=0.956), and negatively with albumin (r=−0.598). ROC analysis demonstrated that LAR had the best discriminative ability for advanced disease (AUC 0.877; 95% CI 0.816–0.939). Conclusion: LAR is a promising and easily obtainable biomarker for identifying advanced-stage MF. Incorporating LAR into clinical assessments may improve risk stratification and support more individualized management. Prospective multicenter studies are warranted to validate these findings and confirm its prognostic utility.

Anahtar Kelimeler

• mycosis fungoides
• lactate dehydrogenase
• serum albumin
• biomarkers
• prognosis

Kaynakça

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