YAŞA BAĞLI MAKULA DEJENERESANSI OLGULARINDA ATEROSKLEROTİK RİSK FAKTÖRLERİNİN DEĞERLENDİRİLMESİ

Öz

Amaç: Yaşa bağlı makula dejeneresansı (YBMD) olgularında aterosklerotik risk faktörlerinin hastalık üzerindeki muhtemel rolünü araştırmak. Metod: Çalışmaya YBMD tamlı 30 hasta dahil edildi. Kontrol grubu, refraksiyon muayenesi için başvuran 30 hasta ile oluşturuldu. Tüm hastalardan, kan lipid kolesterol düzeylerini tayin etmek için, antekübital venöz kan örneği alındı. Alınan örneklerde lipid profili için kolesterol, yüksek yoğunluklu lipoproteinlerin (HDL) ve düşük yoğunluklu lipoproteinlerin (LDL) düzeyleri belirlendi. Sigara kullanımı, hipertansiyon (HT) ve diyabetes mellitus (DM) varlığı ile geçirilmiş serebrovaküler olay (SVO) ve miyokard infarktüsü (MI) ile ilgili anamnez alındı. Bulgular: Yaşa bağlı makula dejeneresansı olan olgularla (18’i erkek 12’si kadın, yaş ortalaması 70,3±7.06) kontrol grubu (18’i erkek 12’si kadın, yaş ortalaması 68,06±6.8) arasında yaş ortalaması (p=0.21) ve cinsiyet dağılımı (p=0.79) açısından istatistiksel açıdan anlamlı bir fark yoktu. Diyabet (p=0.09) ve hipertansiyon (p=0.59) varlığı, MI (p=0.77), SVO (p=0.55) öyküleri ve sigara kullanımı sıklığı (p=0.17) açısından gruplar arasında anlamlı fark saptanmadı. İki grup arasında LDL, HDL, ve total kolesterol düzeyleri açısından istatistiksel anlamlı fark bulunamadı (sırasıyla p değerleri 0.23, 0.19, 0.16 ). Tartışma: Çalışmamızda değerlendirilen ve aterosklerozda başlıca risk faktörlerini teşkil eden serum lipid profili, sigara kullanımı, HT ve DM varlığı, MI ve SVO olay öyküsü açısından YBMD grubu ile kontrol grubu arasında anlamlı fark bulunmamıştır. Ancak olgu sayısının bu tip bir epidemiyolojik çalışma için az olması ve lokal doku lipoprotein reseptöründeki genetik varyasyonlar sonucu etkileyebilir.

Anahtar Kelimeler

• Makulopatiler
• yaşa bağlı
• ateroskleroz
• lipidler

EVALUATION OF THE ATHEROSCLEROTIC RISK FACTORS IN AGE RELATED MACULAR DEGENERATION PATIENTS

Öz

Purpose: To investigate the possible role of atherosclerotic risk factors in age related macular degeneration (AMD) patients. Materials and Method: Thirty patients diagnosed as AMD were included in the study. The control group was made up with the patients who referred for refractive examination. To assess the blood cholesterol levels, antecubital venous blood samples were obtained from all of the patients. Cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) levels in the samples were determined for lipid profile. Anamnesis for cigarette smoking, hypertension and for the presence of diabetes mellitus, previous cerebrovascular event (CVE) and myocardial infarction (Ml) were obtained. Results: There was no statistically significant difference between patients with SMD (18 male 12 female , mean age: 70,3±7.06) and the control group (18 male 12 female, mean age:68,06±6.8) in terms of age (p=0.21), distribution of sex (p=0.79), presence of diabetes mellitus (p=0.09) hypertension (p=0.59) and history of Ml (p=0.77), of CVE (p=0.55) and frequency of smoking (p=0.17).The LDL, HDL and total cholesterol levels were not also significantly different between the groups. (the p levels : 0.23, 0.19, 0.16 respectively). Conclusion: The risk factors for atherosclerosis; i.e. serum lipid profile, cigarette smoking, presence of diabetes and hypertension and history of Ml and CVE were not found to be significantly different in patients with SMD as compared to the control group. However the small number of cases for such an epidemiological study and the genetic variations in lipoprotein receptors in local tissue may affect the results.

Anahtar Kelimeler

• Maculopathies
• age-related
• atherosclerosis
• lipids

Kaynakça

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