Association of Multiple High-Risk Human Papillomavirus Infections with High-Grade Cervical Intraepithelial Lesions

Yıl 2025, Cilt: 25 Sayı: 3, 118 - 123, 25.12.2025

Nilda Nalbant Ayhan Atıgan , İlknur Kaleli , Yeliz Karakaya , Duygu Lafcı , Ömer Tolga Güler

https://izlik.org/JA35NT52EG

Öz

Aim:Cervical cancer is the fourth most common malignancy among women worldwide. Almost all cases are attributed to Human Papillomavirus (HPV) infection, with approximately 70% caused by HPV types 16 and 18. However, data remain limited regarding whether concurrent infection with HPV 16 and other genotypes further increases cervical cancer risk. This study aimed to evaluate the association between combined HPV infections and the presence of high-grade squamous intraepithelial lesions (HSIL).

Material and Methods: Medical records of HPV-positive women who underwent colposcopic examination were retrospectively reviewed. Women aged 25–65 years were included, while those with a history of malignancy, autoimmune disease, or immunosuppressive therapy were excluded. Data regarding HPV genotype, colposcopic findings, and histopathological results were collected from medical records.

Results: A total of 107 patients met the inclusion criteria; 69 (64.5%) had HPV 16 alone, and 38 (35.5%) had HPV 16 with other genotypes. Both groups showed similar baseline characteristics. We also evaluated the relationship between HPV 16 infection, alone or combined with other types, and the presence of HSIL lesions. When pathology results were compared according to HPV types, 27 patients (33.8%) without HSIL had combined HPV types, whereas 11 patients (40.7%) with HSIL had both HPV 16 and other types detected (p = .512).

Conclusion: In our study, the combination of HPV 16 with other HPV types was not found to confer an additional risk for the development of HSIL lesions. Therefore, colposcopic evaluation should be performed in all patients with HPV 16 positivity, even in the absence of coexisting HPV types.

Anahtar Kelimeler

HPV , High-risk HPV , HSIL , Cervical cancer

Birden Fazla Yüksek Riskli İnsan Papilloma Virüsü Enfeksiyonlarının Yüksek Dereceli Servikal İntraepitelyal Lezyonlarla İlişkisi

https://izlik.org/JA35NT52EG

Öz

Amaç:
Serviks kanseri, dünya genelinde kadınlarda en sık görülen dördüncü malignitedir. Olguların neredeyse tamamı persistan yüksek riskli İnsan Papilloma Virüsü (HPV) enfeksiyonuna bağlıdır ve vakaların yaklaşık %70’i HPV tip 16 ve 18 ile ilişkilidir. HPV 16’nın yüksek dereceli servikal lezyonlarla güçlü ilişkisi bilinmekle birlikte, HPV 16’ya eşlik eden diğer HPV genotiplerinin varlığının yüksek dereceli skuamöz intraepitelyal lezyon (HSIL) riskini artırıp artırmadığına dair veriler sınırlıdır. Bu çalışmanın amacı, kombine HPV enfeksiyonları ile HSIL varlığı arasındaki ilişkiyi değerlendirmektir.
Gereç ve Yöntem:
Kolposkopik değerlendirme yapılan HPV pozitif kadın hastaların tıbbi kayıtları retrospektif olarak incelendi. Çalışmaya 25–65 yaş arası kadınlar dâhil edildi; malignite öyküsü, otoimmün hastalık veya immünsüpresif tedavi öyküsü olan hastalar dışlandı. HPV genotipleri, kolposkopik bulgular ve histopatolojik sonuçlara ait veriler hasta dosyalarından elde edildi.
Bulgular:
Çalışma kriterlerini karşılayan toplam 107 hasta analiz edildi. Hastaların 69’unda (%64,5) yalnızca HPV 16 saptanırken, 38’inde (%35,5) HPV 16’ya ek olarak diğer HPV genotipleri mevcuttu. Her iki grubun demografik ve klinik özellikleri benzerdi. Histopatolojik sonuçlar değerlendirildiğinde, HSIL saptanmayan hastaların 27’sinde (%33,8) kombine HPV enfeksiyonu bulunurken, HSIL saptanan 11 hastada (%40,7) HPV 16’ya ek olarak diğer HPV tipleri mevcuttu. Gruplar arasında istatistiksel olarak anlamlı fark saptanmadı (p = 0,512).
Sonuç:
HPV 16’ya eşlik eden diğer HPV genotiplerinin varlığı, HPV 16 enfeksiyonu tek başına olan hastalara kıyasla HSIL gelişme riskini artırmamaktadır. Bu bulgular, HSIL gelişimi açısından HPV 16 pozitifliğinin, ek HPV tiplerinin varlığından bağımsız olarak temel belirleyici olduğunu göstermektedir. Bu nedenle, HPV 16 pozitifliği saptanan tüm hastalarda, eşlik eden diğer HPV tiplerinin varlığına bakılmaksızın kolposkopik değerlendirme yapılmalıdır.

Anahtar Kelimeler

HPV , Yüksek riskli HPV , HSIL , Serviks kanseri

Kaynakça

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