SERVİKS KARSİNOMU VE YÜKSEK DERECELİ SKUAMOZİNTRAEPİTELYAL LEZYONLARDA SERUM FOLAT, VİTAMİN B12,HOMOSİSTEİN VE ESER ELEMENT DÜZEYLERİ

Öz

Objective: To determine folate, vitamin B12, homocysteine, trace elements (zinc, copper, iron), serum iron binding capacity and ferritin levels in cervical cancer and high grade squamous intraepithelial lesion (HSIL) patients. Material and Methods: HSIL and cervical cancer patients, who treated in our gynecologic oncology unit between 2008-2011, were investigated retrospectively.Fifty-four patient were in HSIL group and 65 were in cervical cancer group. Folate, vitamin B12, homocysteine, trace elements (zinc, copper, iron), serum iron binding capacity and ferritin levels, patients age, diagnosis were recorded. Results: There was no statistical significant difference in zinc, iron, folate, B12 levels between HSIL and cervical cancer groups (p>0.05). Copper, serum iron binding capacity, ferritin, homocysteine levels were significantly different between two groups (p<0.05). Between different age groups (under 50 and above 50 years) there were significant difference in serum iron binding capacity, ferritin, homocysteine levels (p<0.001). However, no statistical significant difference in zinc, copper, folate, iron, B12 levels between two age groups were detected. (p>0.05). Conclusion: Future trials are needed to determine the role of serum trace elements, folate, vitamin B12 and homocystein levels in development of cervical preinvasive lesions and carcinogenesis.

Anahtar Kelimeler

• Cervical Cancer
• High Grade Squamous Intraepithelial Lesion
• Vitamin B12
• Folate
• Homocystein
• Trace Element.

SERVİKS KARSİNOMU VE YÜKSEK DERECELİ SKUAMOZİNTRAEPİTELYAL LEZYONLARDA SERUM FOLAT, VİTAMİN B12,HOMOSİSTEİN VE ESER ELEMENT DÜZEYLERİ

Öz

Amaç: Serviks kanseri ve yüksek dereceli skuamoz intraepitelyal lezyon(HSIL) tanısı alan hastalarda folat, vitamin B12 , homosistein, eser element çinko, bakır, demir), serum demir ba¤lama kapasitesi ve ferritin düzeylerinin karşılaştırılması. Materyal ve Metod: Hastanemiz jinekolojik onkoloji klini¤inde 2008-2011 yılları arasında takip ve tedavisi yapılan HSIL ve serviks karsinomu olguları retrospektif olarak incelendi. Elli dört olgu HSIL , 65 olgu ise serviks kanseri tanısı almıştı. Olguların yaşı, biyopsi tanı- sı, serum eser elementleri (çinko, bakır, demir), folat, vitamin B12, ferritin, homosistein düzeyleri ile serum demir ba¤lama kapasitesi (SDBK) kaydedilerek karşılaştırıldı. Olgular ayrıca yaşlarına göre gruplandırılarak karşılaştırıldı. Sonuçlar: Grupların çinko, demir, folat ve B12 ortalamaları arasında istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Bakır, SDBK, ferritin ve homosistein düzeyleri arasında anlamlı fark saptandı (p<0.05). Yaş gruplarına göre, Grup 1(< 50) ile Grup 2 (50 yaş üstü) arasında, SDBK, ferritin, homosistein de¤erleri ortalamaları arasında anlamlı fark saptandı (p<0.001). Çinko, bakır, demir, folat, B12 de¤erleri ortalamaları arasında anlamlı fark yoktu (p>0.05). Sonuç: Serum eser elementleri, folat, vitamin B12 ve homosistein düzeylerinin preinvaziv lezyon oluşumu ve servikal karsinogenezdeki rolünün ortaya konulabilmesi için gelecek çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Serviks Kanseri
• Yüksek Dereceli Skuamoz İntraepitelyal Lezyon
• Vitamin B12
• Folat
• Homosistein
• Eser Element

Kaynakça

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