RISK FACTORS ASSOCIATED WITH PERSISTENCE, RECURRENCE AND PROGRESSION OF CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN) AFTER COLD KNIFE CONIZATION

Yıl 2013, Cilt: 16 Sayı: 2, 44 - 48, 01.04.2013

Dimitrov Go Dimitrov Gl Dzikova E Panov S Ceselkovska M Babusku Gj

Öz

Objective: The aim of this study was to evaluate the significant
risk factors that influence on persistence, recurrence and progression
of CIN after cold-knife conization (CKC)
Design: Prospective follow-up study.
Methods: We retrospectively analyzed the likelihood of recurrent/residual
disease in 143 pa-tients (mean age 39, 3 years, range 22
to 58 years) who underwent cold knife conization for CIN at the
General Hospital Remedika, Department for Gynecology and
Obstetrics, Skopje, Mace-donia in a period of 5 years.
Results: Women with HR- HPV DNA after cold knife conization
had a 17,5 % risk of reccur-ence, whereas 0,8% of women with absent
HR – HPV DNA were with recurrent/persistent CIN.
Conclusion: Persistence of HR-HPV DNA was only significant
risk factor for recurrence and progression of cervical intraepithelial
neoplasia (CIN) after Cold Knife Conization. Women with post-treatment
HR-HPV types should be carefully followed-up every 4 months
in a period of 2 years and all cytology abnormalities, followed by histological
verification should be appropriately treated. Long-term follow-up
strategy is obligatory because HR-HPV infection plays a predominant
role in the pathogenesis of pre-invasive and invasive cervical
cancer.

Anahtar Kelimeler

Cold Knife Conization, CIN, HR- HPV Infection, Persistence, Recurrence.

Kaynakça

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