DIAGNOSIS AND TREATMENT
MODALITIES OF THE VULVAR
INTRAEPITHELIAL NEOPLASIA
Yıl 2014,
Cilt: 17 Sayı: 1, 0 - 0, 01.01.2014
Levent Akman
Enes Taylan
M.coşan Terek
Ahmet Aydın Özsaran
Öz
Vulvar intraepitelial neoplasia (VIN) is the precursor lesion of vulvar carcinoma. VIN also occurs more often in less than 50 years-old
with increasing HPV prevalance. We aim the this article, present to diagnosis and tretment modalities of the VIN.
Kaynakça
- 1. Joura EA, Lösch A, Haider-Angeler, M-G, Breitenecker G,
Leodolter S. Trends in vulvar neoplasia: increasing incidence
of vulvar intraepitelial neoplasia and squamous
cell carcinoma of the vulva in young women. J Reprod
Med 2000;45:613-9.
- 2. Sturgeon SR, Brinton LA, Devesa SS, Kurman RJ. In situ
and invasive vulvar cancer incidence trends (1973 to
1987). Am J Obstet Gynecol 1992;166 :1482-5
- 3. Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig
BA. Trends in the incidence of invasive and in situ vulvar
carcinoma. Obstet Gynecol 2006;107:1018–22.
- 4. van Seters M, van Beurden M, de Craen AJ. Is the assumed
natural history of vulvar intra epithelial neoplasia III
based on enough evidence? A systematic review of 3322
published patients. Gynecol Oncol 2005;97:645–51.
- 5. Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar
intraepithelial neoplasia: 2004 modifi ed terminology,
ISSVD Vulvar Oncology Subcommittee. J Reprod Med
2005;50: 807-10.
- 6. Muñoz N, Kjaer SK, Sigurdsson K, Iversen OE, Hernandez-Avila
M, Wheeler CM,et al. Impact of human papillomavirus
(HPV)-6/11/16/18 vaccine on all HPV-associated
genital diseases in young women. J Natl Cancer Inst.
2010;102:325-39.
- 7. van Seters M, van Beurden M, ten Kate FJ, Beckmann I,
Ewing PC, Eijkemans MJ, et al. Treatment of vulvar intraepithelial
neoplasia with topical imiquimod. N Engl J
Med 2008;358:1465–73.
- 8. Buscema J, Woodruff JD, Parmley TH, et al.: Carcinoma in
situ of the vulva. Obstet Gynecol 1980 55: 225-30.
- 9. Jones RW, Rowan DM: Vulvar intraepithelial neoplasia III:
a clinical study of the outcome in 113 cases with relation
to the later development of invasive vulvar carcinoma.
Obstet Gynecol 1994 84: 741-5.
- 10. Karakaya B, Cömert EC, Bildaci B, Özen O, Dursun P, Ayhan
A. Vın ıı-vın ııı tanısı alan hastalarda skinning vulvektomi
prosedürü:15 hastalık vaka sunumu. Türk Jinekolojik
Onkoloji Dergisi 2010, 12: 43-46.
- 11. Management of vulvar intraepithelial neoplasia. Committee
Opinion No. 509. American College of Obstetricians
and Gynecologists. Obstet Gynecol 2011;118:1192–
VULVAR İNTRAEPİTELYAL
NEOPLAZİDE TANI VE TEDAVİ
YAKLAŞIMLARI
Yıl 2014,
Cilt: 17 Sayı: 1, 0 - 0, 01.01.2014
Levent Akman
Enes Taylan
M.coşan Terek
Ahmet Aydın Özsaran
Öz
Vulvar intraepitelyal neoplazi, vulvanın prekanseröz lezyonudur. Artan HPV sıklığı ile beraber 50 yaş altında da sık ortaya çıkabilmektedir.
Makalemizde, vulvar intraepitelyal neoplazi tanı ve farklı tedavi seçeneklerini sunmayı amaçladık.
Kaynakça
- 1. Joura EA, Lösch A, Haider-Angeler, M-G, Breitenecker G,
Leodolter S. Trends in vulvar neoplasia: increasing incidence
of vulvar intraepitelial neoplasia and squamous
cell carcinoma of the vulva in young women. J Reprod
Med 2000;45:613-9.
- 2. Sturgeon SR, Brinton LA, Devesa SS, Kurman RJ. In situ
and invasive vulvar cancer incidence trends (1973 to
1987). Am J Obstet Gynecol 1992;166 :1482-5
- 3. Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig
BA. Trends in the incidence of invasive and in situ vulvar
carcinoma. Obstet Gynecol 2006;107:1018–22.
- 4. van Seters M, van Beurden M, de Craen AJ. Is the assumed
natural history of vulvar intra epithelial neoplasia III
based on enough evidence? A systematic review of 3322
published patients. Gynecol Oncol 2005;97:645–51.
- 5. Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar
intraepithelial neoplasia: 2004 modifi ed terminology,
ISSVD Vulvar Oncology Subcommittee. J Reprod Med
2005;50: 807-10.
- 6. Muñoz N, Kjaer SK, Sigurdsson K, Iversen OE, Hernandez-Avila
M, Wheeler CM,et al. Impact of human papillomavirus
(HPV)-6/11/16/18 vaccine on all HPV-associated
genital diseases in young women. J Natl Cancer Inst.
2010;102:325-39.
- 7. van Seters M, van Beurden M, ten Kate FJ, Beckmann I,
Ewing PC, Eijkemans MJ, et al. Treatment of vulvar intraepithelial
neoplasia with topical imiquimod. N Engl J
Med 2008;358:1465–73.
- 8. Buscema J, Woodruff JD, Parmley TH, et al.: Carcinoma in
situ of the vulva. Obstet Gynecol 1980 55: 225-30.
- 9. Jones RW, Rowan DM: Vulvar intraepithelial neoplasia III:
a clinical study of the outcome in 113 cases with relation
to the later development of invasive vulvar carcinoma.
Obstet Gynecol 1994 84: 741-5.
- 10. Karakaya B, Cömert EC, Bildaci B, Özen O, Dursun P, Ayhan
A. Vın ıı-vın ııı tanısı alan hastalarda skinning vulvektomi
prosedürü:15 hastalık vaka sunumu. Türk Jinekolojik
Onkoloji Dergisi 2010, 12: 43-46.
- 11. Management of vulvar intraepithelial neoplasia. Committee
Opinion No. 509. American College of Obstetricians
and Gynecologists. Obstet Gynecol 2011;118:1192–