COMPLICATIONS OF HUMAN PAPILLOMA VIRUS VACCINES

Yıl 2014, Cilt: 17 Sayı: 3, 0 - 0, 01.07.2014

Türkan Gürsu , Güldeniz Desteli Ali Ayhan

Öz

HPV 16/18 bivalent vaccines and HPV 6/11/16/18 quadrivalent vaccines are protective vaccines against cervical carcinoma as
prooved by many studies so far. The PATRICIA study revealed that due to cross protective effect against other types of viruses, the
preventative field of current vaccines’ are enlarged. Bivalent vaccines show dominant protection against HPV 18 than quadrivalent
vaccines. The effects and side effects of both vaccines are discussed in large case series till this day. EINSTEIN studied vaccines in
aspect of creation of immunogenic response and related complications . In the literature, short term complications are grouped as
hypersensitivity reactions, local side effects, and among long term complications there are demyelinizating diseases, autoimmune
thyroditis, endocrinopathies and other systemic diseases. In this study we rewieved current short and long term complications of
HPV vaccines.

Anahtar Kelimeler

HPV, Cervix cancer, HPV vaccine, Vaccine complications

HUMAN PAPİLLOMA VİRÜS AŞILARININ KOMPLİKASYONLARI

Öz

HPV tip 16,18 e karşı etkili bivalan ve HPV tip 6,11,16,18 e karşı etkili kuadrivalan HPV aşılarının koruyuculuğu birçok çalışma ile
kanıtlanmıştır. PATRICIA çalışması ile diğer HPV tiplerine karşı da çapraz reaksiyonlar ile aşıların koruyucu olduğu bildirilmiştir. Bivalan
aşının HPV 18’e karşı koruyuculuğu daha baskındır. Her iki aşının etkileri ve komplikasyonları birçok çalışma ve vaka serileri ile
tartışılmış, EINSTEIN’ın çalışmasında aşıların immun cevap oluşturabilmeleri ve komplikasyonları incelenmiştir. Literatürde erken
dönemde hipersensitiveite reaksiyonları, lokal etkiler ve uzun dönem etkiler arasında demiyelinizan hastalıklar, otoimmun tiroiditler,
endokrin ve sistemik hastalıklar araştırılmıştır. Biz bu çalışmamızda HPV aşılarının kısa ve uzun dönem komplikasyonlarını
inceledik

Anahtar Kelimeler

HPV, Serviks kanseri, HPV aşıları, Aşı komplikasyonları

Kaynakça

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