Öz
The use of Cyclosporine A (CsA) in cancer is
increasing based on its inhibiting effect on the calcineurin/nuclear factor of
activated T-cells (NFAT) pathway in immune cells. However, its oxidative stress
related toxic side effects reduces its therapeutic potential. Therefore, the
protective effect of Erdosteine (ER) against CsA-induced injury in rat testis
was firstly investigated in the present study. 32 Wistar albino male rats were
randomly divided into four groups; control, CsA (20 mg/kg/day i.p.), CsA + ER
(ER 12 mg/kg/day orally) and only ER. Malondialdehyde (MDA), catalase (CAT),
nitrite/nitrate (expressed as NO), superoxide dismutase (SOD) and glutathion peroxidase
(GSH-Px) levels were evaluated in addition to histological analysis. MDA and NO
levels were significantly increased in CsA group compared to control group.
However, MDA and NO levels significantly decreased in CsA + ER groups compared
to CsA group (p <0,05). Antioxidant enzymes CAT and GSH-Px activities in CsA
group were significantly lower than control group, while CAT activities in CsA
+ ER were significantly lower than other groups (p<0,05). Histological
degeneration in CsA group was significant compared to other groups. Improvement
in ER + CsA group was significant compared to CsA group. In conclusion ER could
have a protective role against testicular injury induced by CsA with its
antioxidant properties
Anahtar Kelimeler
THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY
Kaynakça
- Turgut Ozal University Vocational School of Health Sciences Pathology Laboratory Tecniques Programme, Ankara
- Mustafa Kemal University, Medical Faculty, Department of Biochemistry, Antakya, Hatay
- Akdeniz University, Medical Faculty, Department of Biochemistry, Antalya
Öz
Kaynakça
- Turgut Ozal University Vocational School of Health Sciences Pathology Laboratory Tecniques Programme, Ankara
- Mustafa Kemal University, Medical Faculty, Department of Biochemistry, Antakya, Hatay
- Akdeniz University, Medical Faculty, Department of Biochemistry, Antalya
Ayrıntılar
| Bölüm | Articles |
|---|---|
| Yazarlar | |
| Yayımlanma Tarihi | 16 Şubat 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology |
