Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer

Yıl 2022, , 116 - 122, 29.12.2022

Esra Bağda , Rümeysa Durak , Efkan Bağda , Didem Duman , Ebubekir Ayhan

https://doi.org/10.51435/turkjac.1203081

Cited By: 1

Öz

Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana ve en bilinen özellikleridir. Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur. G-quadruplex'in çeşitli ligandlarla stabilizasyonu veya destabilizasyonu, hücre proliferasyonunda bozulmalara neden olabilir. Dolayısıyla, bu ikincil yapının stabilizasyonu veya destabilizasyonu önemli antikanser ilaç hedefleridir. Bu çalışmada, Bismarck kahverengi Y-Pd kompleksi, kolay, tek aşamalı bir karıştırma yöntemiyle oluşturulmuştur. Kompleksin spektral özellikleri ve stokiyometrisi, Uv-vis spektrofotometrik olarak araştırıldı. 1:2, Bismarck Brown Y-Pd kompleksinin AS1411 G-dörtlü yapı ile etkileşimi spektrofotometrik titrasyon ile araştırıldı. Bağlanma sabitleri hesaplandı ve 4.38 (±1.96) x104 M-1 olarak bulundu. Kompleksin G-dörtlü konformasyon üzerindeki etkisi CD spektroskopisi ile araştırıldı. Etkileşimlerin varlığı, yüksek hassasiyetli LED kaynaklı floresan dedektör Qsep100 kapiler jel elektroforez sistemi kullanılarak DNA polimeraz durdurma testi ile desteklenmiştir.

Anahtar Kelimeler

G-quadruplex DNA, As1411, Bismarck brown Y, Palladium, CD spectroscopy, capillary gel electrophoresis

Proje Numarası

2209-A -application number 1919B012006417

Kaynakça

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