Leishmania sp. ile Doğal Enfekte Köpeklerin Arthrosentezinde Ksilazinin Elektrokardiyografik Etkisi

Yıl 2023, Cilt: 2 Sayı: 1, 1 - 4, 28.10.2023

Canberk Balıkçı , İbrahim Akın , Kerem Ural , Mehmet Gültekin

Öz

Amaç: Bu çalışmanın amacı Leishmania sp. ile doğal enfekte köpeklerde, artikulasyo genu eklemlerinin aseptik artrosentezi için preanestezik ajan olarak ksilazin ile sedasyon uygulanan köpeklerdeki elektrokardiyografik değişiklikleri araştırmaktı. Gereç-Yöntem: On üç enfekte yetişkin melez köpeğe (8 erkek, 5 dişi) premedikasyon olarak 1.5 mg/kg Xylazine HCl intramusküler olarak uygulandı. On iki derivasyonlu bilgisayarlı elektrokardiyografik muayeneler premedikasyondan önce ve indüksiyondan 30 dakika sonra yapıldı. Poliartritli köpeklerin artikulasiyo genu eklemlerinde amastigot tespiti için sinovyal sıvı yaymaları mikroskop altında değerlendirildi. Kanin visseral leishmaniasis tanısı Leishmania test kitleri (IDEXX SNAP® Leishmania Test) ve immünofloresan antikor testine (IFAT) dayanılarak konulmuştur. Bulgular: Sinovyal sıvı (SF) yaymaları mikroskopi altında değerlendirildi ve 11 köpeğin (%84,61) artikulasiyo eklemlerinin SF'sinde amastigotlar tespit edildi. Ksilazin uygulamasından önce ve ilk uygulamada 1'er vakada hafif sinüs taşikardisi ve atriyal prematüre kompleksi görüldü. Ksilazin uygulamasından 30 dakika sonra bradikardi (6/13), hafif sinüs taşikardisi (2/13), atriyal prematüre kompleksi (2/13), ventriküler prematüre kompleksi (2/13) ve birinci derece AV blok (1/13) görüldü. Sonuç: Ksilazin ile premedikasyon bradikardi, hafif sinüs taşikardisi, atriyal/ventriküler prematüre kompleks veya birinci derece AV blok gibi istenmeyen yan etkilere neden olmuştur ve bu da CVL'li köpeklerde ksilazin kullanımının dikkatle yapılması gerektiğini düşündürmektedir. Özellikle herhangi bir sedatif uygulamasından önce kardiyolojik muayene yapılmalıdır. Ayrıca, doğal enfekte köpeklerde Leishmania sp. enfeksiyonunun parazitolojik teşhisi için SF analizinin avantajlı olabileceği sonucuna varıldı.

Anahtar Kelimeler

Arthrosentez, elektrokardiyografi, kanin Visceral leishmaniasis, ksilazin, sinoviyal sıvı

Electrocardiographic Effects of Xylazine in Arthrocentesis of Dogs Naturally Infected with Leishmania sp.

Öz

Objective: Aim of this study was to investigate electrocardiographic alterations to those of dogs naturally infected with Leishmania sp., in which sedated with xylazine as preanesthetic agent for aseptic arthrocentesis of the stifle joints. Material and Methods: Thirteen diseased adult mix dogs (8 male, 5 female) were administered 1.5 mg/kg Xylazine HCl intramuscularly as premedication. Twelve lead computerized electrocardiographic examinations were made before premedication and at 30 min after induction. The synovial fluid smears were evaluated under microscopy for amastigotes detection in stifle joints of dogs with polyarthritis. A diagnosis of canine visceral leishmaniasis was made based on Leishmania test kits (IDEXX SNAP® Leishmania Test) and the immunofluorescence antibody test (IFAT). Results: The synovial fluid (SF) smears were evaluated under microscopy and amastigotes were detected in the SF of stifle joints of 11 dogs (84.61%). Before xylazine administration and on initial administration mild sinus tachycardia and atrial premature complex were evident in 1 each cases. Following 30 minutes of xylazine administration bradycardia (6/13), mild sinus tachycardia (2/13), atrial premature complex (2/13), ventricular premature complex (2/13) and first degree AV block (1/13) were noticed. Conclusion: Premedication with xylazine induced undesirable side effects involving bradycardia, mild sinus tachycardia, atrial/ventricular premature complex or first degree AV block which might suggest that the usage of xylazine in dog with CVL, must be done with cautions. Especially prior to any sedative administration cardiologic examination must be performed. It might also concluded that SF analysis for the parasitological diagnosis of Leishmania sp. infection in naturally infected dogs might be advantageous.

Anahtar Kelimeler

Canine visceral leishmaniasis, artrocentesis, synovial fluid, xylazine, electrocardiography

Kaynakça

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