Ankaferd Alters Behavior on Stress and Aging in Drosophila melanogaster?

Öz

In the study designed on the basis of movement and rhythm disorders that increase with aging according to free radical theory, the effect of Ankaferd Blood Stopper was tested on the model organism. Movement activity was stimulated by hydrogen peroxide in Drosophila melanogaster males, which are models for metabolic disorders and neurodegenerative diseases. It has been determined that combined use in the fly reduces the climbing induced by ROTs.

Anahtar Kelimeler

• Ankaferd
• Fruit fly
• climbing
• free radical
• gender

Ankaferd Blood Stopper, Drosophila melanogaster'de Stres ve Yaşlanma Üzerindeki Davranışı Değiştiriyor mu?

Öz

Serbest radikal teorisine göre yaşlanma ile artan hareket ve ritim bozukluklarından yola çıkılarak tasarlanan çalışmada, Ankaferd Blood Stopper'ın etkisi model organizma üzerinde denenmiştir. Metabolik bozukluklar, nörodejeneratif hastalıklarda model olan Drosophila melanogaster erkeklerinde hidrojen peroksit ile hareket aktivitesi uyarılmıştır. Sinekte kombine kullanımın ROT'lar ile uyarılan tırmanmayı azalttığı belirlenmiştir.

Anahtar Kelimeler

• Ankaferd
• Meyve sineği
• tırmanma
• serbest radikal
• cinsiyet

Kaynakça

1. [1] Rosenzweig, E. S., Barnes, C. A., 2003, Impact of aging on hippocampal function: plasticity, network dynamics, and cognition, Progress in neurobiology, 69(3), 143-179.
2. [2] Suzuki, Y., Critchley, H. D., Suckling, J., Fukuda, R., Williams, S. C., Andrew, C., Jackson, S. H., 2001, Functional magnetic resonance imaging of odor identification: the effect of aging, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(12), M756-M760.
3. [3] Cerf-Ducastel, B., Murphy, C., 2003, FMRI brain activation in response to odors is reduced in primary olfactory areas of elderly subjects, Brain research, 986(1-2), 39-53.
4. [4] Prvulovic, D., Van de Ven, V., Sack, A. T., Maurer, K., Linden, D. E., 2005, Functional activation imaging in aging and dementia, Psychiatry Research: Neuroimaging, 140(2), 97-113.
5. [5] Yeoman, M. S., Faragher, R. G. A., 2001, Ageing and the nervous system: insights from studies on invertebrates, Biogerontology, 2(2), 85-97.
6. [6] Landis, G. N., Abdueva, D., Skvortsov, D., Yang, J., Rabin, B. E., Carrick, J., Tower, J., 2004, Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster, Proceedings of the National Academy of Sciences, 101(20), 7663-7668.
7. [7] Landis, G. N., Tower, J., 2005, Superoxide dismutase evolution and life span regulation, Mechanisms of ageing and development, 126(3), 365-379.
8. [8] Grover, D., Yang, J., Tavaré, S., Tower, J., 2008, Simultaneous tracking of fly movement and gene expression using GFP, BMC biotechnology, 8(1), 1-10.

9. [9] Jazwinski SM. 2000. Aging and longevity genes. ActaBiochim Pol 47:269–279
10. [10] Feany, M. B., Bender, W. W., 2000, A Drosophila model of Parkinson's disease, Nature, 404(6776), 394-398.
11. [11] Martinez, V. G., Javadi, C. S., Ngo, E., Ngo, L., Lagow, R. D., Zhang, B., 2007 Age related changes in climbing behavior and neural circuit physiology in Drosophila, Developmental neurobiology, 67(6), 778-791.
12. [12] Grotewiel, M. S., Martin, I., Bhandari, P., Cook-Wiens, E., 2005, Functional senescence in Drosophila melanogaster, Ageing research reviews, 4(3), 372-397.
13. [13] Martin, I., Grotewiel, M. S., 2006, Oxidative damage and age-related functional declines, Mechanisms of ageing and development, 127(5), 411-423.
14. [14] Landis, G. N., Abdueva, D., Skvortsov, D., Yang, J., Rabin, B. E., Carrick, J., Tower, J., 2004, Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster, Proceedings of the National Academy of Sciences, 101(20), 7663-7668.
15. [15] Goker, H., Haznedaroglu, I. C., Ercetin, S., Kirazli, S., Akman, U., Ozturk, Y., Firat, H. C., 2008, Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper®, Journal of International Medical Research, 36(1), 163-170.
16. [16] Öner, A. F., Doğan, M., Kaya, A., Sal, E., Bektaş, M. S., Yesilmen, O., Acikgoz, M., 2010, New coagulant agent (ankaferd blood stopper) for open hemorrhages in hemophilia with inhibitör, Clinical and Applied Thrombosis/Hemostasis, 16(6), 705-707.
17. [17] Satar, N. G., Cangül, I. T., Topal, A., Oktay, A., Inan, K., Akgül, M. B., 2014, Effects of Ankaferd Blood Stopper (ABS) and topical tripeptide copper complex (TCC) on wound healing in rats: An experimental study, Kafkas Universitesi Veteriner Fakultesi Dergisi, 20(4), 545-551.
18. [18] Grover, D., Ford, D., Brown, C., Hoe, N., Erdem, A., Tavaré, S., Tower, J., 2009, Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster, PloS one, 4(10), e7580.
19. [19] Güneş, E., Büyükgüzel, E., 2017, Oxidative effects of boric acid on different developmental stages of Drosophila melanogaster Meigen, 1830 (Diptera: Drosophilidae), Türkiye Entomoloji Dergisi, 41(1), 3-15.
20. [20] Zhang, Z., Han, S., Wang, H., Wang, T., 2014, Lutein extends the lifespan of Drosophila melanogaster, Archives of gerontology and geriatrics, 58(1), 153-159.
21. [21] Gargano, J. W., Martin, I., Bhandari, P., Grotewiel, M. S., 2005, Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila, Experimental gerontology, 40(5), 386-395.
22. [22] Peng, C., Zuo, Y., Kwan, K. M., Liang, Y., Ma, K. Y., Chan, H. Y. E., Chen, Z. Y., 2012, Blueberry extract prolongs lifespan of Drosophila melanogaster, Experimental gerontology, 47(2), 170-178.
23. [23] Bartholomew, N. R., Burdett, J. M., VandenBrooks, J. M., Quinlan, M. C., Call, G. B., 2015, Impaired climbing and flight behaviour in Drosophila melanogaster following carbon dioxide anaesthesia, Scientific reports, 5(1), 1-10.
24. [24] Madabattula, S. T., Strautman, J. C., Bysice, A. M., O’Sullivan, J. A., Androschuk, A., Rosenfelt, C., Bolduc, F., 2015, Quantitative analysis of climbing defects in a Drosophila model of neurodegenerative disorders, Journal of visualized experiments: JoVE, (100).
25. [25] Spierer, A. N., Yoon, D., Zhu, C. T., Rand, D. M., 2021, FreeClimber: Automated quantification of climbing performance in Drosophila, Journal of Experimental Biology, 224(2).
26. [26] Güneş, E., 2021, Antioxidant effects of ankaferd blood stopper doped polyvinyl pyrolidon in an experimental model created in insect, Food and Chemical Toxicology, 148, 111935.
27. [27] Greenspan, R. J., Dierick, H. A., 2004, Am not I a fly like thee? From genes in fruit flies to behavior in humans, Human molecular genetics, 13(suppl_2), R267-R273.
28. [28] Zheng, Y., Xue, Y., Ren, X., Liu, M., Li, X., Jia, Y., Ji, J. Y., 2018, The lysine demethylase dKDM2 is non-essential for viability, but regulates circadian rhythms in Drosophila, Frontiers in genetics, 9, 354.
29. [29] Wen, D. T., Zheng, L., Li, J. X., Lu, K., Hou, W. Q., 2019, The activation of cardiac dSir2-related pathways mediates physical exercise resistance to heart aging in old Drosophila, Aging (Albany NY), 11(17), 7274.
30. [30] Pesah, Y., Pham, T., Burgess, H., Middlebrooks, B., Verstreken, P., Zhou, Y., Mardon, G., 2004, Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress, Development, 131(9), 2183-2194.
31. [31] Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., Pallanck, L. J., 2003, Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants, Proceedings of the National Academy of Sciences, 100(7), 4078-4083.
32. [32] Hazır, C., Gamze, B., Yurter, H. E. 2021, Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli, Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(2), 237-245.
33. [33] Fernandez-Ayala, D. J., Sanz, A., Vartiainen, S., Kemppainen, K. K., Babusiak, M., Mustalahti, E., Jacobs, H. T., 2009, Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Cell metabolism, 9(5), 449-460.
34. [34] Deepashree, S., Niveditha, S., Shivanandappa, T., Ramesh, S. R., 2019. Oxidative stress resistance as a factor in aging: evidence from an extended longevity phenotype of Drosophila melanogaster, Biogerontology, 20(4), 497-513.
35. [35] Simon, A. F., Liang, D. T., Krantz, D. E., 2006, Differential decline in behavioral performance of Drosophila melanogaster with age, Mechanisms of ageing and development, 127(7), 647-651.
36. [36] Curtis, C., Landis, G. N., Folk, D., Wehr, N. B., Hoe, N., Waskar, M., , Tower, J., 2007, Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes, Genome biology, 8(12), 1-27.
37. [37] He, Y., Jasper, H., 2014, Studying aging in Drosophila, Methods, 68(1), 129-133.