PFAPA Atakları Sırasında Serum İmmünoglobulin Konsantrasyonlarının Değerlendirilmesi

Öz

Bu çalışmada PFAPA atakları sırasında örnek alınan çocuklar ile yaşça benzer kontrol grubu arasında toplam serum IgG, IgA ve IgM konsantrasyonlarının karşılaştırılması ve serum amiloid A (SAA) dahil olmak üzere akut faz belirteçlerinin incelenmesi amaçlandı. Çalışmaya, PFAPA atağı sırasında örnek alınan 65 çocuk ile örnekleme sırasında klinik olarak sağlıklı olan ve bilinen herhangi bir sistemik hastalığı bulunmayan, yaşça benzer 45 kontrol dahil edildi. Toplam IgG, IgA ve IgM konsantrasyonları ile yaşa özgü referans aralığının altında değer saptanma sıklığı gruplar arasında karşılaştırıldı. C-reaktif protein (CRP), eritrosit sedimentasyon hızı (ESH), fibrinojen ve SAA düzeyleri de gruplar arasında karşılaştırıldı. Klinik ve demografik veriler tıbbi kayıtlardan elde edildi. Ortanca yaş PFAPA grubunda 56 ay, kontrol grubunda ise 57 aydı. Toplam IgG, IgA ve IgM konsantrasyonları gruplar arasında farklılık göstermedi (sırasıyla p=0,897, p=0,173 ve p=0,304) ve yaşa özgü referans aralığının altındaki değerler her iki grupta da seyrek olarak gözlendi. Buna karşılık CRP, ESH, fibrinojen ve SAA düzeyleri PFAPA grubunda daha yüksekti. Ortanca SAA düzeyi PFAPA grubunda 300,0 mg/L (n=51), kontrol grubunda ise 21,8 mg/L (n=28) olarak saptandı (p=0,011). Bulgular, PFAPA atakları sırasında belirgin bir akut faz yanıtı görülmesine karşın total immünoglobulin eksikliğinin sık görülmediğini göstermektedir.

Anahtar Kelimeler

• PFAPA
• İmmunglobulinler
• Serum Amiloid A Proteini
• Akut Faz Reaksiyonu

Destekleyen Kurum

Yazarlar, bu çalışmanın herhangi bir finansal destek almadığını beyan eder.

Etik Beyan

Çalışma Etik Kurul tarafından onaylanmıştır (TBEK 2026/01-15). Çalışma, Helsinki Bildirgesi ve ilgili kurumsal gereklilikler doğrultusunda yürütülmüştür.

Teşekkür

Yazarlar İngilizce dil düzenlemesi ve dil bilgisi kontrolü için Grammarly’yi (Grammarly, Inc., San Francisco, CA, ABD) kullanmıştır. Önerilen tüm değişiklikler yazarlar tarafından gözden geçirilmiş ve onaylanmıştır.

Evaluation of Serum Immunoglobulin Concentrations During PFAPA Attacks

Öz

This study aimed to compare total serum IgG, IgA, and IgM concentrations between children sampled during periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) attacks and an age-similar control group and to examine acute-phase markers, including serum amyloid A (SAA). The study included 65 children with PFAPA sampled during an attack and 45 age-similar controls who were clinically healthy at the time of sampling and had no known systemic disease. The total IgG, IgA, and IgM concentrations and the frequency of values below the age-specific reference range were compared between the groups. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, and SAA levels compared between the groups. Clinical and demographic data were obtained from medical records. The median age in the PFAPA group was 56 months, and in the control group, it was 57 months. Total IgG, IgA, and IgM concentrations were not different between the groups (p=0.897, p=0.173, and p=0.304, respectively), and values below the age-specific reference range were rarely observed in both groups. In contrast, CRP, ESR, fibrinogen, and SAA levels were higher in the PFAPA group. The median SAA level was 300.0 mg/L (n=51) in the PFAPA group and 21.8 mg/L (n=28) in the control group (p=0.011). The findings indicate that, despite a marked acute-phase response during PFAPA attacks, total immunoglobulin deficiency is uncommon.

Anahtar Kelimeler

• PFAPA
• Immunoglobulins
• Serum Amyloid A Protein
• Acute-Phase Reaction

Destekleyen Kurum

The authors declare that this study received no financial support.

Etik Beyan

Approval was granted by the Ethics Committee (TBEK 2026/01-15). The study was conducted in accordance with the Declaration of Helsinki and applicable institutional requirements.

Teşekkür

The authors used Grammarly (Grammarly, Inc., San Francisco, CA, USA) for English-language editing and grammar checking. All suggested changes were reviewed and approved by the authors.

Kaynakça

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