İshal Kaynaklı Sepsisli Neonatal Buzağılarda Hematoloji, Bazı Klinik Biyokimyasal Parametreler ve Mineral Düzeylerinin Değişimi

Öz

Sunulan çalışmada ishal kaynaklı neonatal sepsisli buzağılarda hematolojik, klinik biyokimyasal parametreler ve bazı mineral düzeylerinin değerlendirilmesi amaçlanmıştır. Çalışmanın hayvan materyalini 0-10 günlük yaşta, herhangi bir tedavi uygulanmamış ve sepsis kriterlerini sağlayan 30 ishalli buzağı sepsisli grubu ve aynı yaş grubunda bulunan 20 sağlıklı buzağı kontrol grubunu oluşturdu. Sepsisli buzağılardan tedavi öncesi ve sağlıklı buzağılardan bir kez venöz kan örnekleri alındı. Sepsisli buzağıların dakikadaki kalp frekansı ve solunum sayıları kontrol grubuna göre yüksek olduğu belirlendi. Hematolojik analizlerde sepsisli grupta nötrofil sayısı kontrole göre yüksek bulunurken, eritrosit sayısı ve ortalama eritrosit hacmi düşük bulundu. Biyokimyasal analizlerde ise sepsisli grupta alanin aminotransferaz, aspartat aminotransferaz, üre ve kreatinin düzeyleri kontrol grubuna göre istatistiksel olarak önemli oranda yüksek, magnezyum konsantrasyonları düşüktü (p<0.05). Sonuç olarak ishal kaynaklı sepsisli neonatal buzağılarda karaciğer ve böbrek disfonksiyonu ile ilişkili olarak biyokimyasal parametrelerin yükseldiği, minaral düzeylerinin düştüğü belirlendi. Elde edilen verilerin ortaya çıkmasında ishal kaynaklı dehidrasyonun etkili olabileceği öngörülmüştür. Bu nedenle tedavide özellikle seviyesi düşen minerallerin eklenmesi ve uygun sıvı tedavisi yapılarak normal doku perfüzyonunun sağlanması önemlidir. Doku perfüzyonu sağlanarak, enzim seviyelerinin normale döndürülmesi ile sepsisli buzağıların yaşama şansının artacağını düşünmekteyiz.

Anahtar Kelimeler

• Buzağı
• Mineraller
• Yenidoğan Sepsisi.

Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea

Öz

In this study, it was aimed to evaluate hematology, some clinical and biochemical parameters, as well as mineral levels in calves with neonatal sepsis caused by diarrhea. In this study, 30 calves that were 0-10 days old, who did not receive any treatment and who met the criteria for diarrhea and sepsis within 24 hours at the latest, constitute the sepsis group, and 20 healthy calves in the same age group constitute the control group. Venous blood samples were taken from calves with sepsis before treatment and once from healthy calves. The mean heart rate per minute and respiratory rate were determined higher in the group with sepsis than in the control group. In addition, neutrophil counts were found to be higher in the sepsis group compared to the control group. Erythrocyte count and mean erythrocyte volume were found to be low. While the levels of alanine aminotransferase, aspartate aminotransferase, urea and creatinine were statistically significantly higher in the group with sepsis compared to the control group, magnesium concentrations were lower (p<0.05). As a result, it was determined that biochemical parameters increased and mineral levels decreased in relation to liver and kidney dysfunction in neonatal calves with diarrhea-induced sepsis. The reason for these data to appear may be the result of dehydration from diarrhea. For this reason, it is important in the treatment to ensure normal tissue perfusion, especially by adding minerals with low levels and performing appropriate fluid therapy. We think that the chance of survival of calves with sepsis will increase by ensuring tissue perfusion and restoring enzyme levels to normal.

Anahtar Kelimeler

• Calf
• Minerals
• Neonatal sepsis.

Kaynakça

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