Modulation of the Immune System and Hemogram Parameters by Prunus spinosa in Short-Term Hyperglycemia

Öz

Diabetes mellitus (DM) is one of the chronic diseases, relationship increased blood glucose level, that requires urgent global attention due to its prevalence and associated complications. DM leads to oxidative stress that plays an important role in the development of various complications in diabetes by suppressing the immune system. Prunus spinosa is a plant that has been used in the treatment of many diseases from past to present, thanks to its high antioxidant activity. Therefore, the present study aims to research the effect of P. spinosa leaf and flower mixture on immune system during the short-term diabetic condition. In the study, 56 Wistar albino male rats divided into 7 groups, one of which control and others six diabetic groups, were used to determine the effects of P. spinosa on adenosine deaminase (ADA), (xanthine oxidase) XO and myeloperoxidase (MPO) activities in the liver tissues of diabetic rats as well as on hemogram parameters. Two of these groups were given plant extract in different concentrations (25 and 50 mg/kg bw) and the results were compared with insulin, metformin and acarbose groups. The results showed that both doses administered had a modulating effect on the changing hematological parameters caused by diabetes. Treatment groups significantly decreased ADA, XO, and MPO activities compared to diabetic group. The effects of the PSE50 were found to be more effective than all other treatment. These effects of the plant in diabetesmay be due to its therapeutic immunoregulatory potential. As a result, P. spinosa can be a valuable resource as an adjuvant on diabetes.

Anahtar Kelimeler

• Adenosine deaminase
• Hematology
• Immunity
• Myeloperoxidase
• Prunus spinosa
• Xanthine oxidase

Kısa Süreli Hiperglisemide Prunus spinosa Tarafından Bağışıklık Sistemi ve Hemogram Parametrelerinin Modülasyonu

Öz

Diabetes mellitus (DM), prevalansı ve ilişkili komplikasyonları nedeniyle acil küresel dikkat gerektiren, kan glukoz düzeyi ile ilişkili kronik hastalıklardan biridir. DM, bağışıklık sistemini baskılayarak diyabette çeşitli komplikasyonların gelişiminde önemli rol oynayan oksidatif strese yol açar. Prunus spinosa, yüksek antioksidan aktivitesi sayesinde geçmişten günümüze birçok hastalığın tedavisinde kullanılan bir bitkidir. Bu nedenle, bu çalışma kısa süreli diyabetik durumda P. spinosa yaprak ve çiçek karışımının bağışıklık sistemi üzerindeki etkisini araştırmayı amaçlamaktadır. Çalışmada, diyabetik sıçanların karaciğer dokularında P. spinosa’nın adenozin deaminaz (ADA), ksantin oksidaz (XO) ve miyeloperoksidaz (MPO) aktiviteleri ve hemogram parametreleri üzerine etkilerini belirlemek amacıyla biri kontrol, diğerleri altı diyabetik grup olmak üzere 7 gruba ayrılan 56 Wistar albino erkek sıçan kullanıldı. Bu gruplardan ikisine farklı konsantrasyonlarda (25 ve 50 mg/kg canlı ağırlık) bitki ekstraktı verildi ve sonuçlar insülin, metformin ve akarboz grupları ile karşılaştırıldı. Sonuçlar, uygulanan her iki dozun diyabetin neden olduğu değişen hematolojik parametreler üzerinde modüle edici bir etkiye sahip olduğunu gösterdi. Tedavi grupları, diyabetik gruba kıyasla ADA, XO ve MPO aktivitelerini önemli ölçüde azalttı. PSE50’nin etkilerinin diğer tüm tedavi gruplarından daha etkili olduğu bulundu. Bitkinin diyabetteki bu etkileri, terapötik immün düzenleyici potansiyeline bağlı olabilir. Sonuç olarak P. spinosa, diyabet üzerinde bir adjuvan olarak değerli bir kaynak olabilir.

Anahtar Kelimeler

• Adenozin deaminaz
• Bağışıklık
• Hematoloji
• Ksantin oksidaz
• Miyeloperoksidaz
• Prunus spinosa

Kaynakça

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