Koyunlarda Şap Aşısı ile Birlikte Kullanılan İmmunstimülan İlaçların İmmunglobulinler Üzerine Etkisi

Öz

Koyunlarda şap aşısı ile birlikte kullanılan immunstimülan ilaçların immunglobülinler üzerine etkisi araştırıldı. Bu amaçla 40 adet sağlıklı koyun 4 gruba ayrıldı. Çalışma öncesinde tüm hayvanlardan 0. gün kan ve serum örnekleri alındı. Hematolojik parameterler hemen ölçüldü, biyokimyasal parametrelerden IgA, IgG, IgM, IgE ve Zn değerleri ölçülmek üzere serumlar saklandı. I. gruba sadece şap aşısı uygulandı, II. gruba şap aşısı ile birlikte Levamizol, III. gruba şap aşısı ile birlikte Çinko ve son grup olan IV. gruba da şap aşısı ile birlikte AD3E vitamini uygulandı. 21gün sonra tüm gruplardan kan ve serum örnekleri tekrar alındı ve 0. gün değerlerine göre hem hematolojik hem de IgA, IgG, IgM, IgE ve Zn değerleri kıyaslandı. Hematolojik parametrelerin PLT ve NEU hariç gruplar arasında herhangi bir istatistiksel fark belirlenmedi. 0. ve 21. günlere göre kıyaslamada II. ve III. gruplarda PLT düzeylerinde önemli artış (p<0.05) tespit edilirken IV. grupta NEU duzeyinde istatistiksel olarak azalma görüldü (p<0.05). Biyokimyasal analizlerden IgA, IgG, IgM, IgE değerlerinde, 0. güne göre II. Grupta IgG (p<0,05) ve IgE (p<0,001), III. grupta IgM (p<0,05), IgE (p<0,001) ve IV. grupta sadece IgE (p<0,001) düzeylerinde artis belirlendi. Gruplar arası kıyaslamada da II. ve III. grup IgG düzeyleri kontrol grubuna göre artış belirlendi (p<0,05). Sonuç olarak Şap aşısı ile birlikte kullanılan levamizole veya çinko uygulanmasının hayvanlarda özellikle IgG ve IgM üzerine olumlu etkilerinin olduğu, aşı ile birlikte bu ilaçların uygulanmasının tavsiye edilebileceği kanısına varıldı.

Anahtar Kelimeler

• Immunglobülin,Immunostimülantlar,Koyun,Şap

The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep

Öz

In this study, the effect of used immunostimulating drugs with FMD vaccine on immunoglobulins was aimed to investigate in sheep. For this purpose 40 healthy sheep were divided into 4 groups. Blood and serum samples were taken from all animals from 0 days before the study. Blood samples were measured immediately, and IgA, IgG, IgM, IgE and Zn values from biochemical parameters were stored for measurement. Group I was applied only FMD vaccine, group II Levamisole with the FMD vaccine, group III Zinc with FMD vaccine and the last group IV AD3E was applied with FMD vaccine. After 21 days, blood and serum samples from all groups were taken again and hematologic and IgA, IgG, IgM, IgE and Zn values were compared according to the values of day 0. No statistical difference was found between the groups except for PLT in hematological parameters (p> 0, 05) when compared to pre-vaccination and post-vaccination. In groups II and III there was a significant increase in PLT levels. Biochemical analysis showed IgA, IgG, IgM and IgE levels to be higher in IgG (p <0, 05) and IgE (p <0,001) in groups II and III when levels compared to before vaccination. There were statistically significant increases in IgM (p <0.05) in group IV.

Anahtar Kelimeler

• Sheep,FMD,immunoglobulin,immunostimulant drugs

Kaynakça

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