PHARMACOTHERAPY of COVID-19

Öz

The novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been described as a global pandemic. Regardless the efforts all over the world, there is still no effective treatment or vaccine. Therefore, prevention, early virus detection and identification methods are crutially important for disease control. Treatment protocols are constantly updated with the results of controlled randomized clinical trials; however, the majority of research with a large number of patients are still not concluded. Individualized medicine is forefront since there is no uniform drug application in treatment as the drug efficacy and safety changes with respect to individual differences (such as changing phenotype, other chronic diseases). Treatment protocols are constantly being updated and drug research using artificial intelligence/in silico methods for new compounds and drug repurposing gained prominence. This review provides updated information on some of the agents used in the treatment of COVID-19.

Anahtar Kelimeler

• COVID-19
• SARS-CoV-2
• pharmacotherapy
• drug repurposing

COVID-19 FARMAKOTERAPİSİ

Öz

SARS-CoV-2'nin neden olduğu yeni koronavirüs hastalığı (COVID-19) global bir pandemi olarak tanımlanmıştır. Tüm dünyada yoğun araştırmalara karşın halen etkili bir tedavisi veya aşısı bulunmamaktadır. Bu nedenle korunma, erken virüs tespiti ve tanımlanma yöntemleri hastalığın kontrolü için önem taşımaktadır. Kontrollü randomize klinik araştırmaların sonuçları ile sürekli olarak tedavi protokolleri güncellenmektedir; ancak çok sayıda hasta ile yapılan araştırmaların çoğunluğu halen devam etmektedir. Bireysel farklılıklara (değişen fenotip, diğer kronik hastalıklar gibi) bağlı ilaç etkinliği ve güvenirliğine ilişkin değişiklikler nedeniyle tedavide tek tip ilaç uygulaması bulunmamaktadır. Tedavi protokolleri sürekli güncellenmektedir ve yapay zeka/in siliko araştırmalarla yeni ilaçların geliştirilmesi ve ilaç yeniden konumlandırma araştırmaları hızla devam etmektedir. Bu derleme, COVID-19 tedavisinde kullanılan bazı ajanlar hakkında güncel bilgi sunmaktadır.

Anahtar Kelimeler

• COVID-19
• SARS-CoV-2
• farmakoterapi
• ilaç yeniden konumlandırma

Teşekkür

Değerli bilimsel katkı ve yönlendirici önerilerinden dolayı Prof.Dr. Ş.Şefik Alkan'a teşekkürlerimizi sunarız.

Kaynakça

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