Plants have been used for thousands of years to increase production, preventing and treatment of diseases in animals. Plants; used simultaneously with conventional drugs in prevention and treatment have the potential to interact with drugs at a pharmacokinetic (Absorption: transporters, complex formation, gastrointestinal motility and pH; Distribution: binding to plasma proteins; Metabolism: Phases I and II reactions; Excretion: urine pH and modulation of transporters) and pharmacodynamic (antagonism, synergism and additive effects) level due to secondary compounds (alkaloids, glycosides, resins, etc.) they have. Although some interactions occur in the form of increased drug efficacy or reduced potential side effects, plant-drug interactions often occur as unwanted effects. These unwanted effects can occur as changes in pharmacokinetic parameters (Cmax, Tmax, and AUC etc.), drug efficacy and toxicity. In this review, it is aimed to give information about medicinal plants, also used in animal health, which have unwanted interaction potential when used with medicines and changes that may occur as a result of the interaction.
Yayımlanma Tarihi : 8 Mayıs 2020
|APA||YİPEL, M , İLHAN, A , TEKELİ, İ , KIRGIZ, F , TÜRK, E , EMİROĞLU, S . (2020). İLAÇLARLA ETKİLEŞİM POTANSİYELİNE SAHİP HAYVAN SAĞLIĞINDA DA KULLANILAN TIBBİ BİTKİLER. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni , 11 (1) , 13-26 . DOI: 10.38137/vetfarmatoksbulten.716684|