PHARMACOLOGICAL APPROACH TO CAT AND DOG BEHAVIOUR DISORDERS

Yıl 2024, Cilt: 15 Sayı: 2, 96 - 112, 31.08.2024

Şükran Çelen Tekedereli , Emine Baydan

https://doi.org/10.38137/vftd.1486096

Öz

Behavioral therapies are primarily used in the treatment of behavioral disorders. Before starting treatment, the underlying cause should first be determined and, if necessary, medication should be used to support these therapies. Factors that lead to behavioral disorders can be either physiological or psychological. Sometimes, behavioral disorders can be treated to a certain level and extent through behavioral therapy, environmental adjustments, and positive reinforcement by the pet owner. In particular, treatment is possible in behavioral disorders due to physiological causes by replacing some biological factors whose release mechanism in the body is impaired or absent. However, to correctly diagnose behavioral disorders, it is first necessary to understand normal animal behavior. In this review, normal animal behaviors will be described, and the pharmacological treatment elements used in behavioral disorders will be discussed.

Anahtar Kelimeler

Cat, dog, behaviour disorders, neurotransmitter, psychopharmacology

KEDİ VE KÖPEK DAVRANIŞ BOZUKLUKLARINA FARMAKOLOJİK YAKLAŞIM

Öz

Davranış bozukluklarının tedavisinde öncelikli olarak davranış terapileri kullanılmaktadır. Tedaviye başlamadan once ilk olarak temelde yatan nedenin tespitinin yapılması ve gerekiyorsa bu terapilere destek amaçlı ilaç kullanımı yapılmalıdır. Davranış bozukluğuna neden olan etkenler fizyolojik ya da psikolojik etkenlerdir. Bazen davranış terapisi, çevrenin düzenlenmesi, hasta sahibinin pozitif yönlendirilmesi ile belirli bir düzeye ve belirli bir noktaya kadar davranış bozukluğu tedavi edilebilmektedir. Özellikle fizyolojik nedenlere bağlı davranış bozukluklarında vücutta salınım mekanizması bozulan ya da olmayan bazı biyolojik faktörlerin yerine konması ile tedavi mümkün olabilmektedir. Bununla birlikte, davranış bozukluklarını doğru teşhis edebilmek amacıyla öncelikle normal hayvan davranışlarını anlamak gerekmektedir. Bu derlemede, normal hayvan davranışları anlatılarak, davranış bozukluklarında kullanılan farmakolojik tedavi unsurları ele alınmıştır.

Anahtar Kelimeler

Kedi, köpek, davranış bozuklukları, nörotransmiter, psikofarmakoloji

Kaynakça

• Abrams, J., Brennen, R., Byosiere, S.E. (2020). Trazodone as a mediator of transitional stree in a shelter: Effects on illness, length of stay and outcome, Journal of Veterinary Behavior, 36, 13-18.
• Arhant, C., Hörschläger, N., Troxler J. (2019). Attitidues of veterinarians and veterinary students to recommendations on how to improve dog and cat welfare in veterinary practice, Journal of Veterinary Behavior, 31, 10-16.
• Atalay, Ö. (2007). Kedi ve köpeklerde bazı davranış problemleri ve sağaltım seçenekleri, Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 1: 147-153.
• Berteselli, G.V., Servida, F., DallÂra, P., Verga, M., Piola, E., Puricelli, M., Palestrini, C. (2005). Evaluation of immunological, stress and behavioural parameters in dogs (canis familiaris) with anxiety-related disorders, 5th International Veterinary Behavioural Meeting, Indiana, 2005, 18-22.
• Boothe, D.M. Drugs that modify animal behavior. Drugs acting on the nervous system. In, Boothe, D.M. Editor. Small animal clinical pharmacology and therapeutics, 2.nd ed. USA. Elsevier Saunders; 2012, pp. 903-931 Bowen, J, Heath, S. (2005). Behavior problems in small animals, practical advice for the veterinary team, 1st ed. USA. Elsevier Saunder
• Crowell-Davis, S.L. Introduction. Drug Selection. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 7-8.
• Crowell-Davis, S.L. Benzodiazepines. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 34-71.
• Crowell-Davis, S.L. Selective serotonin reuptake inhibitors. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 80-110.
• Crowell-Davis, S.L. Monoamine oxidase inhibitors. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 134-147.
• Crowell-Davis, S.L. Tricyclic antidepressants. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1st ed. USA, Blackwell, 2006, pp. 179-206.
• Crowell-Davis, S.L, Landsberg, G. Pharmacology and pheromone therapy. In, Horwitz D.F., Mills D.S. Editors. BSAVA Manual of Canine and Feline Behavioural Medicine 2nd ed. Quedgeley: Gloucester, British SmallAnimal Veterinary Association, 2009, pp. 245-258.
• Denenberg, S., Landsberg, G. Current pharmacological and non-pharmacological approaches for therapy of feline and canine dementia. In, Landsberg, G., Maďari, A., Žilka, N. Editors. Canine and Feline Dementia: Molecular Basis, Diagnostics and Therapy, Springer International Publishing AG, 2017, pp. 129-143.
• Dinwoodie, I.R., Dwyer, B., Zottoka, V., Gleason, D., Dodman, N.H. (2019). Demographics and comorbidity of behavior problems in dogs, Journal of veterinary behavior, 32: 62-71.
• Dodman, N.H., Shuster, L. Psychopharmacology of animal behavior disorders, 1st ed. USA, Blackwell, 1998. Dodurka, T., İskefli, O. (2017). Kedi ve köpeklerde psikojenik dermatozlar, Turkiye Klinikleri J Vet Sci Intern Med-Special Topics, 3:214-20.
• Haaften, K.A., Grigg, E.K., Kolus, C., Hart, L., Kogan, L.R. (2020). A survey of dog owners perceptions on the use of psychoactive medications and alternatives fort he treatment of canine behavior problems, Journal of Veterinary Behavior, 35: 27-33.
• Houpt, K.A. . Domestic animal behavior for veterinarians and animal scientists, 5th. ed. USA, Wiley-Blackwell, 2011.
• Kanıcı, A., Doğan, A. (2003). Davranış bozukluğu olan kedilerin tedavisinde ilaçların kullanılması, Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 9: 223-227.
• Kaur G., Voith VL., Schmidt PL. (2016). The use of fluoxetine by veterinarians in dogs and cats: a preliminary survey, Vet Rec Open, 3: e000146.
• Kaya, S. Merkezi Sinir Sistemi İlaçları Giriş. İçinde Kaya S. Editor. Veteriner farmakoloji, Cilt:1, 6th ed. Ankara. Turkey: Medisan Yayınları, 2014, pp. 193-203.
• Kaya, S. Psikotrop İlaçlar. İçinde, Kaya S. Editor. Veteriner farmakoloji, Cilt:1, 6th ed. Ankara. Turkey: Medisan Yayınları, 2014, pp. 259-274.
• Landsberg, G., Hunthausen, W., Ackerman, L. (2013). Behavior problems of the dog and cat, 3rd. ed. USA. Elsevier Saunder
• Miklosi, A. (2007). Methodological issues in the behavioural study of the dog. In, Miklosi, A. Editor. Dog behaviour, evolution and cognition, 1st. ed. New York, Oxford university press, 2007, pp. 27-45.
• Mills, D. (2011). Behavior problems and psychopharmacology. Journal of Veterinary Behavior: Clinical Applications and Research, 6:96-97.
• Murray, T. Amino acid neurotransmitters: Glutamate, GABA and the pharmacology of benzodiazepines. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 25-33.
• Murray, T. Biogenic amine transmitters: Acetylcholine, norepinephrine and dopamine. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 119-133.
• Murray, T. Biogenic amine transmitters: Serotonin. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 72-79.
• Overall, K.L. (2001). Pharmacological treatment in behavioural medicine: The importance of neurochemistry, molecular biology and mechanistic hypotheses, The Veterinary Journal, 162: 9–23.
• Overall, K.L. (2013). Manual of clinical behavioral medicine for dogs and cats, Elsevier, 122-512.
• Overall, K.L. Behavioral pharmacotherapeutics. In, Mealey, K. L. Editor. Pharmacotherapeutics for veterinary dispensing, 1st. ed. USA, Wıley-Blackwell, 2019, pp. 377-401.
• Özaytekin-Akbaş, E. (2007). Sağlıklı ve dominant agresyonlu köpeklerde monoamin düzeylerinin değerlendirilmesi, İstanbul, Turkey, Thesis of PhD, IU, diss.
• Pageat, P., Gaultier, E. (2003). Current research in canine and feline pheromones. Veterinary Clinics: Small Animal Practice, 33: 187-211.
• Polo, G., Calderon, N., Clothier, S., Garcia, R.C.M. (2015). Understanding dog aggression: Epidemiologic aspects, Journal of Veterinary Behavior, 10: 525-534.
• Salgırlı-Demirbaş, Y., Emre, B. (2015). Stresin köpeklerde davranış üzerine etkileri, Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 3: 34-42 .
• Salgırlı-Demirbaş, Y. (2015). Golden retriever ırkı bir köpekte uygunsuz alan savunma agresyonu ve sahiplenici agresyonun davranış terapisi ile tedavisi, Veteriner Hekimler Derneği Dergisi, 86:36-41 .
• Schneider, B.M., Dodman, NH., Maranda, L. (2009). Use of memantine in treatment of canine compulsive disorders, Journal of Veterinary Behavior, 4: 118-126.
• Seibert, L.M. Antipsychotics. In, Crowell-Davis, S.L., Murray, T. Editors. Veterinary psychopharmacology, 1 st ed. USA, Blackwell; 2006 pp. 148-165.
• Simpson, B.S., Papich, M.G. (2003). Pharmacologic management in veterinary behavioral medicine, Veterinary Clinics: Small Animal Practice, 33: 365–404.
• Sinn, L. (2018). Advances in behavioral psychopharmacology, Veterinary Clinics: Small Animal Practice, 48: 457-471.
• Stein, D.J. Introduction: Steps Toward a Comparative Clinical Psychopharmacology.In, Dodman, N.H., Shuster, L. Editors. Psychopharmacology.of animal behavior disorders, 1st ed. USA, Blackwell; 1998 pp. 1-14.
• Tutun, H., Baydan, E. (2018). Reseptör Analizinde Radyoligand Bağlanma Deneyleri, Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 15: 161-168.
• Weiss, E., Miller, K., Mohan- Gibbons, H., Vela, C. (2012). Why did you choose this pet. Adopters and pet selection preferences in five animal shelters in the United States, Animals, 2:144-159.