Deli Bal ve Kronik Obstrüktif Akciğer Hastalığı (KOAH)’nı yatıştırmada yardımcı olabilecek potansiyel mekanizmaları.

Yıl 2025, Cilt: 6 Sayı: 2, 55 - 58, 07.09.2025

Özge Zelal Aydın , Ayşegül Akbay

Öz

Giriş: Kronik Obstrüktif Akciğer Hastalığı nefes darlığı, kronik enflamasyon ve akciğerlerde yapısal hasar ile kendini gösteren ilerleyici bir hastalıktır. Hastalığa, hava yolu yeniden şekillenmesi, fibröz ve oksidatif strese yol açan, özellikle sigara dumanı ve çevresel kirleticiler gibi irritan maddelere uzun-süreli maruziyet sebep olmaktadır. Güncel tedaviler semptomları yönetmeye yardımcı olsa da kesin bir tedavi sağlamamakta ve çok ciddi sağlık masraflarıyla birlikte, morbidite ve mortalite oranları hâlâ oldukça yüksek seyretmektedir. Bu sebepten, güncel tedavilere eşlik eden alternatif ve doğal tedavilere olan ilgi her geçen gün artmaktadır. Bunlara örnek olarak ender bulunan ve Rhododendron türlerinden, özellikle Rhododendron ponticum ve Rhododendron luteum, elde edilen ‘Deli Bal’ verilebilir.

Sonuç: Bu tartışmada, Deli Bal’ın Kronik Obstrüktif Akciğer Hastalığı semptomlarını yatıştırma ve akciğer fonksiyonlarını geliştirmede yardımcı olma potansiyeli taşıyan mekanizmalar, farklı moleküler ve biyolojik mekanizmalar göz önünde bulundurularak incelenmiştir.

Anahtar Kelimeler

KOAH , deli bal , rhododendron , enflamasyon

Mad Honey and Its Possible Biological Mechanisms in Alleviating Chronic Obstructive Pulmonary Disease (COPD)

Öz

Introduction: Chronic Obstructive Pulmonary Disease is a progressive respiratory condition characterized by airflow limitation, chronic inflammation, and structural damage in the lungs The disease is primarily caused by long-term exposure to irritants, particularly cigarette smoke and, leading to airway remodeling, fibrosis, and oxidative stress. Although, current treatments help manage symptoms, they do not offer a definitive cure, and the morbidity and mortality rates are still high with very significant healthcare costs. Therefore, there is growing interest in alternative and natural remedies that may complement conventional therapies. One such substance is mad honey a rare and potent type of honey derived from the nectar of Rhododendron species, particularly Rhododendron ponticum and Rhododendron luteum.

Conclusion: In this commentary, we explore the possible mechanisms, by which mad honey could alleviate Chronic Obstructive Pulmonary Disease symptoms and improve lung function,considering different molecular and biological aspects.

Anahtar Kelimeler

COPD , mad honey , rhododendron , inflammation

Kaynakça

• Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. Lancet. 2022;399(10342):2227–2242. https://doi.org/10.1016/S0140-6736(22)00470-6
• Barnes PJ. Oxidative stress in chronic obstructive pulmonary disease. Antioxidants (Basel). 2022;11(5):965. https://doi.org/10.3390/antiox11050965
• Xu J, Zeng Q, Li S, Su Q, Fan H. Inflammation mechanism and research progress of COPD. Front Immunol. 2024;15:1404615. https://doi.org/10.3389/fimmu.2024.1404615
• Polverino F, Sin DD. Type 2 airway inflammation in COPD. Eur Respir J. 2024;63(5):2400150. https://doi.org/10.1183/13993003.00150-2024
• Raby KL, Michaeloudes C, Tonkin J, Chung KF, Bhavsar PK. Mechanisms of airway epithelial injury and abnormal repair in asthma and COPD. Front Immunol. 2023;14:1201658. https://doi.org/10.3389/fimmu.2023.1201658
• Khan IA, Khan M. A fascinating tale of mad honey: no longer enigmatic. PIAS. 2025;2:00119.
• Thapa AJ, Chapagain S, Lamichhane S, Aryal E, Sapkota A, Ghimire A, etal. Mad honey (wild honey) poisoning: clinical case series from Nepal. Ann Med Surg (Lond). 2024;86(9):4975–4978. https://doi.org/10.1097/MS9.0000000000002448
• Gunduz A, Şimşek P, Ayaz FA. Worldwide distribution and clinical characteristics of mad honey poisoning cases. Cent Eur J Public Health. 2023;31(1):69–73. https://doi.org/10.21101/cejph.a7501
• Yang J, Zhao J, Zhang J. The efficacy and toxicity of grayanoids as analgesics: a systematic review. J Ethnopharmacol. 2022;298:11558. https://doi.org/10.1016/j.jep.2022.115581
• Ranneh Y, Akim AM, Hamid HA, Khazaai H, Fadel A, Zakaria ZA, et al. Honey and its nutritional and anti-inflammatory value. BMC Complement Med Ther. 2021;21(1):30. https://doi.org/10.1186/s12906-020-03170-5
• Aga MB, Sharma V, Dar AH, Dash KK, Singh A, Shams R, et al. Comprehensive review on functional and nutraceutical properties of honey. Int Food Res J. 2023;4(2):e71. https://doi.org/10.1002/efd2.71
• Teyani RL, Moghaddam F, Moniri NH. ROS-mediated regulation of β2AR function: does oxidation play a meaningful role towards β2-agonist tachyphylaxis in airway obstructive diseases? Biochem Pharmacol. 2024;226:116403. https://doi.org/10.1016/j.bcp.2024.116403
• Schrenk D, Bignami M, Bodin L, Chipman JK, Mazo J, Grasl-Kraupp B, et al. Risks for human health related to the presence of grayanotoxins in certain honey. EFSA J. 2023;21(3):e07866. https://doi.org/10.2903/j.efsa.2023.7866
• Marques L, Vale N. Salbutamol in the management of asthma: a review. Int J Mol Sci. 2022;23(22):14207. https://doi.org/10.3390/ijms232214207
• Shah BK, Singh S, Wang Y, Xie S, Wang C. Mucus hypersecretion in chronic obstructive pulmonary disease and its treatment. Mediators Inflamm. 2023;2023:8840594. https://doi.org/10.1155/2023/8840594
• Xu M, Li X, Song L. Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway. Pharm Biol. 2020;58(1):655–663. https://doi.org/10.1080/13880209.2020.1779318
• Sainz-Mejías M, Jurado-Martín I, McClean S. Understanding Pseudomonas aeruginosa –host interactions: the ongoing quest for an efficacious vaccine. Cells. 2020; 9(12):2617. https://doi.org/10.3390/cells9122617
• Clark LA, Reed R, Corazzini KN, Zhu S, Renn C, Klinedinst NJ. COPD- related fatigue: a scoping review. Clin Nurs Res. 2023;32(5):914–928. https://doi.org/10.1177/10547738221141224
• Christiansen CF, Løkke A, Bregnballe V, Prior TS, Farver-Vestergaard I. COPD-related anxiety: a systematic review of patient perspectives. Int J Chron Obstruct Pulmon Dis. 2023;18:1031–1046. https://doi.org/10.2147/COPD.S404701