Ferritin as acute phase reactant and its use in threatened preterm labor

Abstract

Objective: To determine the relation of serum ferritin levels in patients with threatened preterm labor as indicator of infection and neonatal outcomes. Material and Methods: The trial group was consisted of 100 patients who were admitted to the Zeynep Kamil Women and Children Hospital Maternity Clinic as threatened preterm labor between November 2001- June 2002. The control group was consisted of 50 pregnant women with 24-35 weeks of pregnancy who were in the control of the antenatal outpatient clinic of the same hospital between May 2002-July 2002. Than, In pregnants with preterm labored , the relation between ferritin and neonatal outcome was evaluated. In this randomized prospective study, the serum ferritin levels were compared between the groups. Results: The serum ferritin levels were found significantly higher in threatened preterm labor group (17.3 ±21.7 ng/ml) than the control group (10.2±7.8 ng/ml) (p

Keywords

• Acute-Phase Reaction,Acute-Phase Proteins,Prospective Studies,Ferritin

Akut faz reaktanı olarak ferritin ve erken doğum tehdidinde kullanımı

Öz

Amaç: Serum ferritin düzeyinin erken doğum tehdidi nedeniyle başvuran hastalarda, enfeksiyon göstergesi olarak kullanımı ve neonatal sonuçlarla ilişkisinin araştırılması. Materyal ve Metod: Zeynep Kamil Kadın ve Çocuk Hastalıkları Hastanesi Doğum Kliniği'ne Kasım 2001-Haziran 2002 tarihleri arasında Erken Doğum Tehdidi (EDT) tanısı ile yatırılan 100 hasta çalışma grubunu; Mayıs 2002-Temmuz 2002 tarihleri arasında aynı kliniğin gebe İzlem Polikliniğinde gebelik kontrollerine devam eden, 24-35'inci gebelik haftaları arasındaki 50 gebe kontrol grubunu oluşturdu. Daha sonra, erken doğum yapan gebelerde ferritin ve neonatal sonuçlar arasındaki bağlantı değerlendirildi. Randomize prospektif olarak düzenlenen çalışmada, ferritin düzeyleri gruplar arasında karşılaştırıldı. Bulgular: Erken doğum tehdidi nedeniyle başvuran gebelerde ferritin düzeyi (17.3±21.7 ng/ml) kontrol grubu (10.2±7.8 ng/ml) ile karşılaştırıldığında anlamlı olarak yüksek bulundu (p

Anahtar Kelimeler

• Akut faz reaksiyonu,Akut faz proteinleri,İleriye dönük çalışma,Ferritin

Kaynakça

1. 1. Creasy RK, Iams JD . Preterm labor and delivery. In: Creasy RK, Resnik R.,eds. Maternal-Fetal Medicine. 4th ed. Philadelphia: WB Saunders Company, 1999: 498-531
2. 2. Kushner I. The acute phase response:an overview. Methods Enzymol 1988; 163:373-83
3. 3. Tamura T , Goldenberg RL. Serum ferritin: Apredic tor of early spontaneus preterm delivery. Obstet Gynecol Mar 1996; 87(3):360-5
4. 4. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 1974; 290:1213-6
5. 5. Entman SS, Richardson LD, Killam AE Elevated serum ferritin in the altered ferroki-netics of toxemia of pregnanacy. AM J Obstet Gynecol 1982; 144:418-22
6. 6. Cresay RK: Preterm birth: Where are we? Am J Obstet Gynecol 1993; 168:1223
7. 7. Kaneshige E. Serum ferritin as an assessment of iron stores and other hematologic parameters during pregnancy. Obstet Gynecol 1981; 57:238-42
8. 8. Summers M, Worwood M, Jacobs A. Ferritin in normal erythrocytes, lymphocytes, polymorps and monocytes. Br j Haematol 1974; 28:19-26

9. 9. Casey ML, MacDonald PC. Biomolecular processes in the initiation of parturation: Decidual activation. Clin Obstet Gynecol 1988; 31:533-52
10. 10. Saha CK, Jain V, Gupta I, Varma N. Serum ferritin level as a marker of preterm labor. Int J Gynacol Obstet Nov 2000; 11. Goldenberg RL, Mercer BM. Plasma ferritin, premature rupture of membranes,and pregnancy outcome. Am J Obstet Gynecol Jan 1998; 179:1601-6
11. 12. Geyr TN, Makek A, Mathez-Loic F, Altermatt HJ, Bodmer T: Permeation of human chorioamniotic membranes by Escherichia coli in vitro. Am J Obstet Gynecol,1994; 170:223
12. 13. Goldenberg RL, Andrews WW, Guerrant RL, Newman M, Mercer BM, lams J, et al. The preterm prediction study: Cervical lactofer-rin concentration, other markers of lower genital tract infection,and preterm birth. Am J Obstet Gynecol 2000; 182:631-5
13. 14. Gibbs RS, Romero R, Hiller SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1992; 166:1515-28
14. 15. Goldenberg RL, Tamura T: Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol, Nov 1996; 175(5):1356-9
15. 16. Tamura T , Goldenberg RL. Serum ferritin: Apredictor of early spontaneus preterm delivery. Obstet Gynecol Mar 1996; 87(3):360-5
16. 17. Yücesoy G, Çorakçı A, Gümüştaş G, Özeren S; Gebelik gidişinde serum ferritin değerlerinin önemi. T Klin Gynecol Obstet 1999; 9,175-178.