Erkek infertilitesinde seminal leptin seviyelerinin semen parametreleri ve DNA fragmantasyonu ile ilişkisi

Öz

Giriş: Bu çalışmamızda insan semen leptin düzeylerini ve semen parametreleri ile ilişkisinin incelenmesi amaçlanmıştır.

Materyal-Metod: Normal ve oligoastenoteratospermik 30 hastalık gruplar oluşturuldu. Hastaların semen örneklerinde leptin ve DNA fragmantasyon düzeyleri incelendi, ayrıca sperm sayısını ve motilite oranlarını içeren semen parametreleri değerlendirildi.

Bulgular: İnfertil hastalarda sperm sayısı ve motilite oranları normal gruba göre anlamlı olarak azalmıştır: 6,40±4,29 (x10⁶/mL), % 38,63±14,92 (p<0,0001). DNA fragmantasyon oranları normal grupta % 21,00±8,23 olarak gözlenirken infertil erkeklerde % 38,43±14,23  oranıyla anlamlı olarak yüksek bulunmuş, semen leptin oraları ise normal grupta 347,58±111,13 ng/mL olarak  gözlenirken, infertil grupta 267,63±56,36 ng/mL düzeyi ile anlamlı olarak azaldığı gözlenmiştir. İnfertil gruplar kendi içinde incelendiği zaman ise semen leptin düzeyi ile yaş, volüm, sperm sayısı ve motilitesi arasında istatistiksel olarak anlamlı olacak bir ilişki saptanmamıştır.

Sonuç: Çalışmamızda, oligoastenoteratozoospermik erkek infertilitesinde serum leptin seviyelerinin azalmış olduğunu, ama sperm motilitesi ile anlamlı bir ilişkinin bulunmadı gözlemlenmiştir. Leptinin semende tanısal bir kriter olarak kullanılabilmesi için daha geniş kapsamlı çalışmaların yapılması gerektiği düşünülmektedir

Anahtar Kelimeler

• Leptin,oligoastenoteratozoospermi,erkek infertilitesi

The relationship of seminal leptin levels with semen parameters and DNA fragmentation

Abstract

Objective: The objective of this study is to investigate the relationship between human seminal leptin levels and semen parameters.

Material & Methods: Study groups include 30 males with oligoasthenoteratozoospermia and 30 males who have normal semen parameters. Leptin and DNA fragmentation levels were investigated in both groups, along with a variety of semen parameters including sperm count and motility.

Results: In comparison with the normal males, sperm count and motility have decreased significantly in infertile patients: 6,40±4,29(x10⁶/mL), %, 38,63±14,92 (p<0,0001).  DNA fragmentation levels were found as 21,00±8,23 %   and 38,43±14,23 %,  in normal and patient groups respectively. Seminal leptin levels were 347,58±111,13 ng/mL in the normal group, while there was a significant decrease to 267,63±56,36 ng/mL in the infertile group. Among infertile patient groups, no significant difference was observed regarding the relationship between seminal leptin levels and age, volume, sperm count and motility.

Conclusion: In our study it was demonstrated that, serum leptin levels decrease in oligoasthenoteratozoospermic infertile males, while there is not a significant relation with the motility of sperm. In order to use seminal leptin levels as a diagnostic tool more extensive studies are needed.

Keywords

• Leptin,oligoasthenoteratozoospermia,male infertility

Kaynakça

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