Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği

Öz

Objective: Rheumatoid heart disease (RHD) is an important
and preventable cause of cardiovascular disease in developing
countries. The aim of this study was to investigate the mean
platelet volume (MPV) and platelet distribution width (PDW)
in RHD.
Material and Methods: This study was carried out in Kayseri
Health Sciences University, Department of Pediatric Cardiology, with 135 children with RHD who were retrospectively
observed between February 2000 and February 2017 for seven
years and 40 healthy children with similar age and sex.
Results: The mean age of the 135 patients enrolled in the study
was 12,43 ± 3,11 years, 70 were males (51,8%) and 65 were
females (48,2%). The mean age of the control group was 12,96
± 2,55 years, 21,21 male (52,5%) and 19 female (47,5%). MPV
values of the patients were significantly lower in the RHD
group (9,43 ± 1,31 and 10,21 ± 1,25, p: 0,003).

Conversely, the PDW levels were significantly higher in the
RHD group (15,70 (15,40-16,00) and 12,25 (10,40-14,30), p:
0,001). When MPV / PDW ratio was examined, it was found to
be significantly lower in the RHD group (0,61 (0,55-0,71) and
0,87 (0,79-0,93), p: 0,001).
Conclusion: MPV values were lower and PDW values were higher when compared to controls in RHD process.

Anahtar Kelimeler

• mean platelet volume
• platelet distribution width
• rheumatic heart disease
• child

Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği

Öz

Amaç: Romatizmal kalp hastalığı (RKH), kardiyovasküler hastalıkların gelişmekte olan ülkelerde endemik seyreden önemli ve önlenebilir bir nedenidir. Bu çalışmanın amacı RKH’da ortalama trombosit hacmini (MPV) ve trombosit dağılım genişliğini (PDW) araştırmaktır. Materyal ve Metod: Bu çalışma Kayseri Sağlık Bilimleri Üniversitesi Çocuk Kardiyoloji Bölümü’nde, Şubat 2000-Şubat 2017 tarihleri arasında retrospektif olarak yedi yıllık süreçte izlenen 135 RKH’li çocuk hasta ile yaş ve cinsiyetleri benzer 40 sağlıklı çocuğu içermektedir. Bulgular: Çalışmaya alınan 135 olgunun yaş ortalaması 12,43±3,11 yıl, 70’i erkek (%51,8), 65’i kız (%48,2) idi. Kontrol grubunun yaşları ortalaması 12,96±2,55 yıl, 21’i erkek (%52,5)),19‘u kız (%47,5) olmak üzere 40 idi. Hastaların MPV değerleri RKH’lı grupta anlamlı derecede düşüktü (9,43±1,31 ve 10,21±1,25; p:0,003). Tersine PDW seviyeleri RKH’lı grupta anlamlı derecede yüksekti (15,70 (15,40-16,00) ve 12,25(10,40- 14,30); p: 0,001). MPV/PDW oranı RKH’lı grupta anlamlı derecede düşük saptandı (0,61(0,55-0,71) ve 0,87(0,79 0,93); p: 0,001). Sonuç: RKH sürecinde kontrol grubuyla kıyaslandığında MPV düşüklüğü ve PDW yüksekliği mevcutttur.

Anahtar Kelimeler

• ortalama trombosit hacmi
• trombosit dağılım genişliği
• romatizmal kalp hastalığı
• çocuk

Kaynakça

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