LAMOTRIGİNE INDUCED PROBABLE DRESS SYNDROME: CASE REPORT

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS Syndrome) is a rare, life-threatening, drug- induced hypersensitivity reaction that include skin eruptions, hematologic abnormalities (eosinophilia, atypical lymphocytosis), lymphadenopathy and internal organ involvement (liver, kidney, lung). We present an adolescent girl with probable DRESS Syndrome who had rash and fever after having been treated with lamotrigine as antiepileptic drug before fourteen days.  

LAMOTRİGİNE BAĞLI OLASI DRESS SENDROMU: OLGU SUNUMU

Öz

DRESS Sendromu (Drug Rush with Eosinophilia and Systemic Symptoms) ilaç ilişkili döküntü,  hematolojik anormallikler (eozinofili, atipik lenfositoz), lenfadenopati, iç organ tutulumları (karaciğer, böbrek, akciğer) ile seyreden nadir, hayatı tehdit edebilen hipersensitivite reaksiyonudur. Antiepileptik lamotrigin tedavisi başlandıktan on dört gün sonra döküntüsü ve ateşi gelişen DRESS Sendromu olduğu düşünülen ergen bir kız hastayı sunduk.

Anahtar Kelimeler

• DRESS Sendromu,ilaç hipersensitivitesi,lamotrigine,çocuk

Kaynakça

1. 1-Shear NH, Spielberg SP. Anconvulsant hypersensitivity syndrome. In vitro assessment of risk. J Clin Invest 1988; 82 (6):1826-32.
2. 2-Halevy S, Feuerman EJ. Pseudolymphoma syndrome.Dermatologica 1977;155: 321.
3. 3-Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Liss Y, Chu CY, Creamer D, ve ark. Drug reaction with eosinophilia and systemic symptoms(DRESS): an original multisystem advers drug reaction.Results from the prospective RegiSCAR study. Br J Dermatol 2013; 169(5):1071-80.
4. 4-Wang XQ, Lv B, Zhang X, Yu Sy, Huang XS, Zhang JT, ve ark.Lamotrigine induced DIHS/ DRESS: Manifestations, treatment, and outcome in 57 patients. Clin Neurol Neurosurg 2015; 138:1-7.
5. 5-Büyüköztürk S, Kekik Ç, Gökyiğit AZ, Tezer Filik FI, Karakaya G, Saygı S, ve ark. Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population. Eur Ann Allergy Clin Immunol 2018; 50(1): 36-41.
6. 6-De Luca F, Losappio LM, Mirone C, Schroeder JW, Citterio A, Aversano MG, ve ark. Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature. Clin Mol Allergy 2017;15:16. doi: 10.1186/s12948-017-0072-5. eCollection 2017
7. 7-Ramirez E, Medrano-Casique N, Tong Hy, Bellon T, Cabanas R, Fiandor A, ve ark. Eosinophilic drug reactions detected by a prospective pharmacovigilance programme in a tertiary hospital. BR J Clin Pharmacol 2017; 83(2): 400-415.
8. 8-Sasidhararnpillai S, Sabitha S, Riyaz N, Binitha MP, Muhammed K, Riyaz A, ve ark. Drug reaction with eosinophilia anda systemic symptoms in children: a prospective study. Pediatr Dermatol 2016; 33(2):e162-5. Doi: 10.1111/pde.12803.

9. 9-Erdem SB, Nacaroglu HT, Bag O, Karkiner CS, Korkmaz HA, Can D. DRESS Syndrome associated with type 2 diabetes in a child. Cent Eur J Immunol 2015; 40(4):493-6.
10. 10-Yazıcıoğlu M. Çocukluk çağında ilaç alerjilerine yaklaşım. Türk Ped Arş 2014; 49: 99-103.
11. 11-Brockow K, Romano A, Blanca M, Ring J, Pichler W, Demoly P. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 2002; 57(1): 45-51.
12. 12-Aberer W, Bircher A, Romano A, Blanca M, Campi P, Fernandez J, et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions. Allergy 2003; 58 (9): 854-63.
13. 13-Funck-Brentano E, Duong TA, Bouvresse S, Bagot M, Wolkenstein P, Roujeau JC, et al. Therapeutic management of DRESS: a retrospective study of 38 cases. J Am Acad Dermatol 2015; 72 (2): 246-252.
14. 14-Kaykı G, Özsürekçi Y, Arslanoğlu E, Akın MŞ, Saçkesen C, Orhan D, et al. DRESS Sendromu: Bir olgu sunumu. J Pediatr Inf 2016; 10: 99-103.