BibTex RIS Kaynak Göster

Effect of L-thyroxine therapy on bone mineral density in postmenopausal patients

Yıl 2004, Cilt: 35 Sayı: 2, 49 - 53, 01.03.2004

Deniz Köse Oral Özay Tuğrul Semih Yeşilçiçek Şükrettin Alkan Akif

Öz

Objective: to determine the effect of L-thyroxin therapy on bone mineral density in postmenopausal patients Materials and Methods: Fourhundredsixtyeight postmenopausal women were analysed in this study. Thyroid function tests and bone mineral density results were evaluated in all patients. Patients were divided into 3 groups according to BMD as normal, osteopenic and osteoporotic. Control group was consisted of 270 women who had normal BMD. The BMD results of 58 patients taking L-thyroxin therapy were compared with the control group. Results: We compared BMD results of patients who were taking L-tiroksin and the control group. Osteopeni and osteoporozis rates were similar in two groups and there were no significant difference. Conclusion: L-thyroxin therapy at physilogical doses has no effect on BMD in postmenopausal women.

Anahtar Kelimeler

Thyroxine Bone Density Postmenopause

Kaynakça

  • 1. Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy Clin Endoerinol 1990 Aug; 33(2):143-53
  • 2. Greenspan SL, Greenspan FS, Resnick N, Block. JE, Friedlan der AL, Genant HK. Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy. Am J Med 1991; 91:5-14
  • 3. Kung AW, Pun KK. Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. JAMA 1991; 265:2688-91
  • 4. Krolner B, Jorgensen JV, Nielsen SP. Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormones and antithyroid treatment. Clin Endocrinol (Oxf). 1983;18:439-46
  • 5. Taelman P, Kaufman JM, Janssens X, Vandecauter H, Vermeulen A. Reduced forearm bone mineral content and biochemical evidence of increased bone turnover in women with euthyroid goitre treated with thyroid hormone. Clin Endocrinol (Oxf). 1990;33:107-17
  • 6. Diamond T, Nery L, Hales I. A therapeutic dilemma: suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. J Clin Endocrinol Metat 1991; 72:1184-88
  • 7. Stall GM, Harris S, Sokoll LJ, Dawson-Hughes B. Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Ann Intern Med. 1990;113:265-9
  • 8. Mosekilde L, Eriksen EF, Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am. 1990;19:35-63
  • 9. Fraser SA, Anderson JB, Smith DA. Osteoporosis and fractures following thyrotoxicosis. Lancet. 1971;1:981-3 10. Ross DS, Neer RM, Chester Ridgway E, Daniels GH. Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. Am J Med. 1987;82:1167-71
  • 11. Krolner B. Nielsen SP. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies
  • Clin Sci 1982:62:329-36 12. Nilas L, Christiansen C. The pathophysiology of peri and postmenopausal bone loss. Br J Obstet Gynecol 1989:96:580-7 13. Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 1986:7:379-408

Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi

Yıl 2004, Cilt: 35 Sayı: 2, 49 - 53, 01.03.2004

Deniz Köse Oral Özay Tuğrul Semih Yeşilçiçek Şükrettin Alkan Akif

Öz

Amaç: Postmenopozal dönemde L-tiroksin tedavisinin kemik 'mineral yoğunluğu (BMD) üzerindeki etkisini değerlendirmek Materyal ve Metod: Hastanemiz menopoz polikliniğine başvuran 468 olgu çalışmaya alındı.Tüm hastalarda tiroid fonksiyon testleri ve BMD sonuçları değerlendirildi. Hastalar BMD'ne göre normal, osteopeni ve osteoporoz olmak üzere üç gruba ayrıldı. BMD'si normal olan 270 olgu kontrol grubunu oluşturdu. L-tiroksin kullanan 58 hastanın sonuçları tedavi almayan olgularla karşılaştırıldı. Bulgular: L-tiroksin kullanan hastalar ile tedavi almayan olguların BMD'leri değerlendirildiğinde her iki grup arasında osteopeni ve osteoporoz açısından anlamlı bir fark saptanmadı. Sonuç: Fizyolojik dozlarda L-tiroksin alan postmenopozal hastalarda kemik mineral yoğunluğu etkilenmemektedir.

Anahtar Kelimeler

Tiroksin Kemik yoğunluğu Postmenopoz

Kaynakça

  • 1. Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy Clin Endoerinol 1990 Aug; 33(2):143-53
  • 2. Greenspan SL, Greenspan FS, Resnick N, Block. JE, Friedlan der AL, Genant HK. Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy. Am J Med 1991; 91:5-14
  • 3. Kung AW, Pun KK. Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. JAMA 1991; 265:2688-91
  • 4. Krolner B, Jorgensen JV, Nielsen SP. Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormones and antithyroid treatment. Clin Endocrinol (Oxf). 1983;18:439-46
  • 5. Taelman P, Kaufman JM, Janssens X, Vandecauter H, Vermeulen A. Reduced forearm bone mineral content and biochemical evidence of increased bone turnover in women with euthyroid goitre treated with thyroid hormone. Clin Endocrinol (Oxf). 1990;33:107-17
  • 6. Diamond T, Nery L, Hales I. A therapeutic dilemma: suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. J Clin Endocrinol Metat 1991; 72:1184-88
  • 7. Stall GM, Harris S, Sokoll LJ, Dawson-Hughes B. Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Ann Intern Med. 1990;113:265-9
  • 8. Mosekilde L, Eriksen EF, Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am. 1990;19:35-63
  • 9. Fraser SA, Anderson JB, Smith DA. Osteoporosis and fractures following thyrotoxicosis. Lancet. 1971;1:981-3 10. Ross DS, Neer RM, Chester Ridgway E, Daniels GH. Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. Am J Med. 1987;82:1167-71
  • 11. Krolner B. Nielsen SP. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies
  • Clin Sci 1982:62:329-36 12. Nilas L, Christiansen C. The pathophysiology of peri and postmenopausal bone loss. Br J Obstet Gynecol 1989:96:580-7 13. Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 1986:7:379-408
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Deniz Köse Bu kişi benim

Oral Özay Bu kişi benim

Tuğrul Semih Bu kişi benim

Yeşilçiçek Şükrettin Bu kişi benim

Alkan Akif Bu kişi benim

Yayımlanma Tarihi 1 Mart 2004
Yayımlandığı Sayı Yıl 2004 Cilt: 35 Sayı: 2

Kaynak Göster

APA Köse, D., Özay, O., Semih, T., Şükrettin, Y., vd. (2004). Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni, 35(2), 49-53. https://doi.org/10.16948/zktb.00368
AMA Köse D, Özay O, Semih T, Şükrettin Y, Akif A. Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni. Mart 2004;35(2):49-53. doi:10.16948/zktb.00368
Chicago Köse, Deniz, Oral Özay, Tuğrul Semih, Yeşilçiçek Şükrettin, ve Alkan Akif. “Postmenopozal dönemde L-Tiroksin Tedavisinin Kemik Mineral yoğunluğu üzerine Etkisi”. Zeynep Kamil Tıp Bülteni 35, sy. 2 (Mart 2004): 49-53. https://doi.org/10.16948/zktb.00368.
EndNote Köse D, Özay O, Semih T, Şükrettin Y, Akif A (01 Mart 2004) Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni 35 2 49–53.
IEEE D. Köse, O. Özay, T. Semih, Y. Şükrettin, ve A. Akif, “Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi”, Zeynep Kamil Tıp Bülteni, c. 35, sy. 2, ss. 49–53, 2004, doi: 10.16948/zktb.00368.
ISNAD Köse, Deniz vd. “Postmenopozal dönemde L-Tiroksin Tedavisinin Kemik Mineral yoğunluğu üzerine Etkisi”. Zeynep Kamil Tıp Bülteni 35/2 (Mart 2004), 49-53. https://doi.org/10.16948/zktb.00368.
JAMA Köse D, Özay O, Semih T, Şükrettin Y, Akif A. Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni. 2004;35:49–53.
MLA Köse, Deniz vd. “Postmenopozal dönemde L-Tiroksin Tedavisinin Kemik Mineral yoğunluğu üzerine Etkisi”. Zeynep Kamil Tıp Bülteni, c. 35, sy. 2, 2004, ss. 49-53, doi:10.16948/zktb.00368.
Vancouver Köse D, Özay O, Semih T, Şükrettin Y, Akif A. Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni. 2004;35(2):49-53.