Impact of vitamin C addition to $Fe^{++}$ supplementation in laboratory response in iron deficiency anemia of childhood
Öz
Objective: To evaluate the effect of adding Vitamine C to $Fe^{++}$ in treatment of iron deficiency anemia in childhood. Materials and Methods: Infants who applied to outpatient clinic of Zeynep Kamil Maternity Hospital and get the diagnosis of iron deficiency anemia were divided into two groups. First group received only $Fe^{++}$, second group received Vitamine C and $Fe^{++}$. Hematological results were evaluated at the end of first and second month. Results: Hemoglobine (p>0.05), hematocrite (p>0.05), MCV (p>0.05), MCHC (p>0.05), MCH (p>0.05), RDW (p>0.05),$Fe^{++}$ (p>0.05), Fe binding capacity (p>0.05), Ferritin (p>0.05), Fe saturation (p>0.05) and leucocyte levels (p>0.05) were similar in the groups. Conclusion: Adding Vitamin C to ferrous iron had no impact on hematological values in anemic children.
Anahtar Kelimeler
Kaynakça
- 1. Baker SJ, de Mayer EM. Nutritional anemia:its understanding and control with special reference to the work of World Health Organisation. Am J Clin Nutr 1979; 32:368-417 2. Committtee on Standarts of Child Health Care: Standarts of Child Health Care, ed 2. Evanston, Illinois, AAP, 1972, p 10) 3. Kuvibidila S, Yu L, Ode D.Mbele V, Warrier RJ. An epidemiological study of hemoglobin levels and prevalance of anemia in young children in Basre
- Ann Soc Belg Med Trop 1993; 73:227-34 4. Hercberg S, Chauliac M, Galan P, et al. Prevalance of iron deficiency and iron deficiency anemia in Benin. Public Health 1988; 102:73-83 5. Molla A, Khurshid M, Molla AM. Prevalance of iron deficiency anemia in children of urban slums of Karachi. J Pak Med Assoc 1992; 42.118-21 6. Calvo EB, Gnazzo N. Prevalance of iron deficiency in children aged 9-24 month from a large urban area of Argentina. Am J Clin Nutr 1990; 52:534-40 7. Kattamis C, Mataxotou MA, Konidaris C, Touliatos N, Constantsas N, Matsaniotis N. Iron deficiency in Greece. Epidemiologic and hematologic studies
- J Pediatr 1974; 84:666-71 8. Oski FA. Disorders of erythrocyte production. In: Nathan DG, Oski FA(eds). Hematology of Infancy and Childhood. Philadelphia, WB Saunders Company, 1993; 391-450 9. Fairbanks VF. Iron deficinecy: still a diagnostic challenge. Med Clin North Am. 1970; 54:903-15 10. Cook JD, Finch CA. Assessing iron status of a population. Am J Clin Nutr 1979; 32:2115-9 11. Lanzkowsky P. Problems in diagnosis of iron deficiency anemia. Pediatr Ann 1985; 14:618-36 12. Domellof M, Dewey KG, Lonnerdal B, Cohen RJ, Hernell O. The diagnostic criteria for iron deficiency in infants should be reevaluated. J Nutr
- 2002 Dec;132(12):3680-6
- 13. McCormick DB, Greene HL. Vitamins. In:Burtis CA, Ashwood ER (eds) Clinical Chemistry. WB Sounders Company, Philadelphia, 1994 pp 1311-3 14. Araş K, Ersen G, Karahan S. Vitamin C (askorbik asid). In: Tıbbi Biyokimya-Vitaminler Ankara Üniv Basımevi, Ankara, 1976, pp 96-111 15. Roeser HP, Halliday JW, Sizemore DJ, Nikles A, Willgoss D. Serum ferhtin in ascorbic acid deficiency. Br J Haematology 1980; 457-466 16. Marx JJ, Stiekema J. Mucosal uptake, mucosal transfer and retention of a therapeutic dose of iron. Eur J Clin Pharmacol 1982; 23:335-8 17. Plug CM, Dekker D, Bult A. Complex stability of ferrous ascorbate in aqueous solution and its significance for iron absorption. Pharm Weekbl 1984; 6:245-8 18. Hungerford DM; Under MC. Interactions of pH and ascorbate in intestinal iron absorption. J Nutr 1983; 113: 2615-22 19. Şaylı TR, Aydın ÖF, İzol R, Kara C, Sarıbaş S. Demir eksikliği anemisinde demir sülfat ve demir hidroksit polimaltoz tedavilerinin etkinliğinin karşılaştırılması ve C vitamininin etkisi. Klinik Bilimler & Doktor. 1999; 5 (2):233-7 20. Brise H, Hallberg L. Effect of ascorbic acid on iron absorbtion. Acta med Scand 1962; 171; 51-8) 21. Hallberg L, Brune M, Rossander-Ulthen L Is here a physiological role of vitamin C in iron absorption? Ann N Y Acad Sci 1987; 498:324-32) 22. May JM, Qu ZC, Mendiratta S. Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells. Biocehm Pharmacol 1999; 57:1275-82 23. Hunt JR, Mullen LM, Lykken GI; Gallagher SK, Nielsen FH. Ascorbic acid: effect of ongoing iron absorption and status in iron-depleted women. Am J Clin Nutr 1990; 51:649-55 24. Seshadri S, Shah A, Bhade S. Haematologic response of anemic preschool children to ascobic acid supplementation. Hum Nutr Appl Nutr 1985; 39: 151-4 25. Mao X, Yao G. Effect of vitamin C supplementations on iron deficiency anemia in Chinese children. Biomed Environ Sci 1992; 5: 125-9 26. Stack T, Aggett PJ, Aitken E, Lloyd DJ. Routine L-ascorbic acid supplementation does not alter iron, copper, and zinc balance in low-birth-weight infants fed a cows'-milk formula. J Pediatr Gastroenterol Nutr 1990; 10:31-6
Çocuklardaki demir eksikliği anemisi'nde $Fe^{++}$ tedavisine C vitamini ilavesinin laboratuar cevabı üzerindeki etkileri
Öz
Amaç: Çocuklardaki Fe eksikliği anemisinde önerilen 2 değerlikli demir preparatlarına C vitamini eklenmesinin sadece $Fe^{++}$ alan gruba göre anemiyi düzeltmedeki etkinliğini saptamak Materyal ve Metod: Zeynep Kamil Kadın Hastalıkları ve Çocuk Hastanesi Çocuk Hastalıkları Polikliniği'ne başvuran çocuklar 2 gruba ayrılarak 1. gruba sadece $Fe^{++}$ , diğer gruba $Fe^{++}$ ve C vitamini başlanarak hematolojik parametreler 1. ay ve 2. ay sonunda değerlendirildi. Bulgular: Kontrol ve çalışma grupları arasında, hemoglobin (p>0.05), hematokrit (p>0.05), MCV (p>0.05), MCHC (p>0.05), MCH (p>0.05), KDW (p>0.05),$Fe^{++}$ (p>0.05), Fe bağlama (p>0.05), Ferritin (p>0.05), Transferrin saturasyonu (p>0.05)ve lökosit (p>0,05) açısından fark bulunmamıştır. Sonuç: Anemi tedavisi alan çocuklarda Ferröz demire ($Fe^{++}$) C vitamin eklenmesinin hematolojik parametrelerin iyileşmesine katkı sağlamadığı saptanmıştır.
Anahtar Kelimeler
Kaynakça
- 1. Baker SJ, de Mayer EM. Nutritional anemia:its understanding and control with special reference to the work of World Health Organisation. Am J Clin Nutr 1979; 32:368-417 2. Committtee on Standarts of Child Health Care: Standarts of Child Health Care, ed 2. Evanston, Illinois, AAP, 1972, p 10) 3. Kuvibidila S, Yu L, Ode D.Mbele V, Warrier RJ. An epidemiological study of hemoglobin levels and prevalance of anemia in young children in Basre
- Ann Soc Belg Med Trop 1993; 73:227-34 4. Hercberg S, Chauliac M, Galan P, et al. Prevalance of iron deficiency and iron deficiency anemia in Benin. Public Health 1988; 102:73-83 5. Molla A, Khurshid M, Molla AM. Prevalance of iron deficiency anemia in children of urban slums of Karachi. J Pak Med Assoc 1992; 42.118-21 6. Calvo EB, Gnazzo N. Prevalance of iron deficiency in children aged 9-24 month from a large urban area of Argentina. Am J Clin Nutr 1990; 52:534-40 7. Kattamis C, Mataxotou MA, Konidaris C, Touliatos N, Constantsas N, Matsaniotis N. Iron deficiency in Greece. Epidemiologic and hematologic studies
- J Pediatr 1974; 84:666-71 8. Oski FA. Disorders of erythrocyte production. In: Nathan DG, Oski FA(eds). Hematology of Infancy and Childhood. Philadelphia, WB Saunders Company, 1993; 391-450 9. Fairbanks VF. Iron deficinecy: still a diagnostic challenge. Med Clin North Am. 1970; 54:903-15 10. Cook JD, Finch CA. Assessing iron status of a population. Am J Clin Nutr 1979; 32:2115-9 11. Lanzkowsky P. Problems in diagnosis of iron deficiency anemia. Pediatr Ann 1985; 14:618-36 12. Domellof M, Dewey KG, Lonnerdal B, Cohen RJ, Hernell O. The diagnostic criteria for iron deficiency in infants should be reevaluated. J Nutr
- 2002 Dec;132(12):3680-6
- 13. McCormick DB, Greene HL. Vitamins. In:Burtis CA, Ashwood ER (eds) Clinical Chemistry. WB Sounders Company, Philadelphia, 1994 pp 1311-3 14. Araş K, Ersen G, Karahan S. Vitamin C (askorbik asid). In: Tıbbi Biyokimya-Vitaminler Ankara Üniv Basımevi, Ankara, 1976, pp 96-111 15. Roeser HP, Halliday JW, Sizemore DJ, Nikles A, Willgoss D. Serum ferhtin in ascorbic acid deficiency. Br J Haematology 1980; 457-466 16. Marx JJ, Stiekema J. Mucosal uptake, mucosal transfer and retention of a therapeutic dose of iron. Eur J Clin Pharmacol 1982; 23:335-8 17. Plug CM, Dekker D, Bult A. Complex stability of ferrous ascorbate in aqueous solution and its significance for iron absorption. Pharm Weekbl 1984; 6:245-8 18. Hungerford DM; Under MC. Interactions of pH and ascorbate in intestinal iron absorption. J Nutr 1983; 113: 2615-22 19. Şaylı TR, Aydın ÖF, İzol R, Kara C, Sarıbaş S. Demir eksikliği anemisinde demir sülfat ve demir hidroksit polimaltoz tedavilerinin etkinliğinin karşılaştırılması ve C vitamininin etkisi. Klinik Bilimler & Doktor. 1999; 5 (2):233-7 20. Brise H, Hallberg L. Effect of ascorbic acid on iron absorbtion. Acta med Scand 1962; 171; 51-8) 21. Hallberg L, Brune M, Rossander-Ulthen L Is here a physiological role of vitamin C in iron absorption? Ann N Y Acad Sci 1987; 498:324-32) 22. May JM, Qu ZC, Mendiratta S. Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells. Biocehm Pharmacol 1999; 57:1275-82 23. Hunt JR, Mullen LM, Lykken GI; Gallagher SK, Nielsen FH. Ascorbic acid: effect of ongoing iron absorption and status in iron-depleted women. Am J Clin Nutr 1990; 51:649-55 24. Seshadri S, Shah A, Bhade S. Haematologic response of anemic preschool children to ascobic acid supplementation. Hum Nutr Appl Nutr 1985; 39: 151-4 25. Mao X, Yao G. Effect of vitamin C supplementations on iron deficiency anemia in Chinese children. Biomed Environ Sci 1992; 5: 125-9 26. Stack T, Aggett PJ, Aitken E, Lloyd DJ. Routine L-ascorbic acid supplementation does not alter iron, copper, and zinc balance in low-birth-weight infants fed a cows'-milk formula. J Pediatr Gastroenterol Nutr 1990; 10:31-6
Toplam 5 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2004 |
| Yayımlandığı Sayı | Yıl 2004 Cilt: 35 Sayı: 2 |