The efficiency of anticholinergic treatment and patient's compliance in urinary incontinent patients
Öz
Objective: to investigate efficiency of anticholinergic medication in patients diagnosed with overactive detrüsor and patient's compliance. Material and Method: In our study, we included 41 women diagnosed with overactive detrüsor by urodynamic scan. The patients were randomly divided into two groups. Tolterodin was the drug used in the first group and trospium in the second group. The efficiency of treatment, side effects of the drugs and causes of drug cessation were noted in 1 year follow up. Independent t test, X2 test and Mann-Whitney U test were used in statistical analyses. Results: In both groups, there were no differences in patients' mean age, duration of complaints and quality of life scores before treatment. 16(%50) patients reported to be satisfied with medication. 8(%25) patients reported that their complaints got worsened. 13(%40) patients did not use medication during 1 year of time. Conclusions: In this study, we observed that anticholinergic treatment's succes rate and patient's compliance were %50. We also observed that, no matter which therapy modalities are chosen, patients' education level and close doctor-patient realationship is important in cases with overactive detrüsor.
Anahtar Kelimeler
Urinary Bladder Overactive Urodynamics Cholinergic Antagonists tolterodine Urinary Incontinence Treatment Outcome Treatment Failure
Kaynakça
- 1- Kleeman SD, Karram MM. Overactive Bladder Syndrome and Nocturia. In: Urogynecology and Reconstructive Pelvic Surgery. Mark D Walters, Mickey M Karram (eds), Mosby, Philadelphia, 2007,3672- 2-Moore KH, Sutherst JR. Response to treatment of detrusor instability in relation to pshychoneurotic status. Br J Urol; 1990,301:271 3-Herbison P, Hay-Smith J, Ellis G, Moore K
- Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review. BMJ. 2003 Apr 19;326(7394): 841-4
- 4- Yu FF, Nichol MB, Yu AP, Ahn J. Persistence and adherence of medications for chronic overactive bladder/urinary incontinence in the California medicaid program Value Health 2005 Jul-Aug; 8(4):495-505
- 5- Cam C, Sakalli M, Ay P, Cam M, Karateke A
- Validation of the short forms of the incontinence impact questionnaire (IIQ-7) and the urogenital distress inventory (UDI-6) in a Turkish population
- Neurourol Urodyn. 2007;26(l): 129-33
- 6- Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, Hunt TL, Wein AJ. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003 May;20(6):327-36
- 7-Hay-Smith J, Herbison P, Ellis G, Murvis A
- Which anticholinergic drug for overactive bladder symptom in adults. Cochrane Database Syst Rew 2005;20:CD005429.
Öz
Amaç: overaktif detrüsor nedeniyle antikolinerjik ilaç kullanan hastalarda, tedavi etkinliği ve hasta uyumunu araştırmak. Materyal ve Metod: Ürojinekoloji kliniğimize başvuran ve ürodinamik inceleme sonucu aşırı aktif mesane tanısı alan 41 bayan hasta çalışmaya dahil edildi. Randomize olarak tolterodin ve trospium ile antikolinerjik tedavi başlandı. 1 yıl süresince tedavinin etkinliği, gözlenen yan etkiler ve ilaçların kullanılmama nedenleri not edildi. Verilerin değerlendirilmesinde independent t test, X2 testi ve Mann-Whitney U testi kullanıldı. Bulgular: Her iki grupta da hastaların yaş ortalamaları, yakınma süreleri ve tedavi öncesi yaşam kalite skorlarında farklılık gözlenmedi. %50(16) hasta tedaviden fayda gördüğünü belirtti. %40(13) hasta ise 1 yıl içerisinde tedaviyi kesti. %25(8) hasta ise yakınmalarının arttığını belirtti. Sonuç: Bu çalışmada, antikolinerjik tedavilerin başarı ve devam oranlarının hastaların ancak yarısı ile sınırlı kaldığını gözlenmiştir. Aşırı aktif mesane olgularında, hangi tedavi modalitesi kullanılırsa kullanılsın, hasta eğitiminin ve daha yoğun bir hasta-hekim ilişkisinin önemli olduğu gözlenmiştir.
Anahtar Kelimeler
Mesane aşırı aktif Ürodinamik Kolinerjik antagonistler tolterodin İdrar kaçırma Tedavi sonucu Tedavi başarısızlığı
Kaynakça
- 1- Kleeman SD, Karram MM. Overactive Bladder Syndrome and Nocturia. In: Urogynecology and Reconstructive Pelvic Surgery. Mark D Walters, Mickey M Karram (eds), Mosby, Philadelphia, 2007,3672- 2-Moore KH, Sutherst JR. Response to treatment of detrusor instability in relation to pshychoneurotic status. Br J Urol; 1990,301:271 3-Herbison P, Hay-Smith J, Ellis G, Moore K
- Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review. BMJ. 2003 Apr 19;326(7394): 841-4
- 4- Yu FF, Nichol MB, Yu AP, Ahn J. Persistence and adherence of medications for chronic overactive bladder/urinary incontinence in the California medicaid program Value Health 2005 Jul-Aug; 8(4):495-505
- 5- Cam C, Sakalli M, Ay P, Cam M, Karateke A
- Validation of the short forms of the incontinence impact questionnaire (IIQ-7) and the urogenital distress inventory (UDI-6) in a Turkish population
- Neurourol Urodyn. 2007;26(l): 129-33
- 6- Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, Hunt TL, Wein AJ. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003 May;20(6):327-36
- 7-Hay-Smith J, Herbison P, Ellis G, Murvis A
- Which anticholinergic drug for overactive bladder symptom in adults. Cochrane Database Syst Rew 2005;20:CD005429.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2008 |
| Yayımlandığı Sayı | Yıl 2008 Cilt: 39 Sayı: 2 |