Human papillonavirüs frequency and typing in licensed sex workers

Yıl 2010, Cilt: 41 Sayı: 4, 177 - 181, 01.05.2010

KART Kadriye Yaşar Filiz Pehlivanoğlu Gönül Şengöz Mehmet Bakar

Öz

Objectives: Human papillomavirus (HPV) is major important pathogen of cervical cancer worldwide and is also a serious problem influencing sex-workers. The aim of this study is to detect HPV frequency among licensed sex-workers, and to determine serotypes and to evaluate whether screening tests for HPV should be done in this risky population. Material and Methods: This study covers regularly controlled 30 sex-workers in Istanbul. The demographic features of cases were collected by questionnaire method. Cervical samples taken from cases were investigated to detect HPVDNA with multiplex polymerase chain reaction (PCR) method and serotypes were determined with reverse hybridization method. Results: Age distribution of sex-workers was 21-50 and 50% of them had vaginal discharge. The half of all patients has been workedfor 6-10 years, 37% of them for more than 15 years as a licensed sex worker. HPV was detected in 4 (13%) of the sex-workers. In two of them HPV serotype were type 16, in one was type 50er which are related with cervical cancer. Conclusions: In conclusion, HPV infections may be seen in regularly controlled sex-workers. Genital HPV infections -if not treated may cause serious complications as cancer- may be detected frequently in sex-workers. Therefore tscreening tests for HPV should be performed in risky groups especially in sex-workers. Now, it is important to screen risky groups for HPV infections that could be prevented with vaccination andfollow-up of positive cases for early diagnosis of cervical cancer and public health.

Anahtar Kelimeler

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Kayıtlı seks işçilerinde human papillomavirüs sıklığı ve tiplendirilmesi

Öz

Amaç: Human papillomavirus (HPV), kadınlarda servikal kanserlerin majör etkeni olup, seks işçilerinde önemi giderek artan bir patojendir. Bu çalışmanın amacı, kayıtlı seks işçilerinde HPV prevalansını saptamak, tiplendirmesini yapmak ve bu popülasyonda, rutin taranmasının gerekli olup olmadığını değerlendirmektir. Yöntem: Bu çalışma, düzenli olarak kontrolleri yapılan 30 seks işçisini kapsamaktadır. Olguların demografik özellikleri, yüz yüze yapılan anketlerle elde edilmiştir. Alınan servikal sürüntü örneklerinde HPV varlığı multipleks PCR yöntemiyle, tiplendirme ise revers hibridizasyon yöntemiyle araştırılmıştır. Bulgular: Çalışma grubunda yer alan seks işçilerinin yaş dağılımı 21-50 olup, %50'sinde vajinal akıntı mevcuttu. Olguların yarısı 6-10 yıldır, %37'si ise 15yıldan uzun süredir kayıtlı seks işçisi olarak çalışmaktaydı. Seks işçilerinin dördünde HPV DNA pozitif bulundu (%13). HPV pozitif saptanan hastaların ikisinde tip 16, birinde servikal kanserle ilişkili tip 50er, diğerinde ise düşük riskli HPV saptandı. Tartışma: Sonuç olarak, düzenli sağlık kontrolleri yapılan kayıtlı seks işçilerinde bile HPVinfeksiyonu görülebilmektedir. Tedavi edilmediğinde kanser gibi ciddi komplikasyonlara neden olabilen genital HPV enfeksiyonu; seks işçileri gibi riskli gruplarda mutlaka taranmalıdır. Günümüzde aşı ile korunabilen bu hastalıkta riskli grupların taranması ve pozitif bulunanların takibi, servikal kanserlerin erken teşhisi ve toplum sağlığı açısından önemlidir.

Anahtar Kelimeler

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Kaynakça

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