Güneydoğu Anadolu Bölgesi jüvenil idiyopatik artrit hastalarında alt tip dağılımı ve üveit sıklığı

Yıl 2020, Cilt: 51 Sayı: 1, 27 - 30, 15.01.2020

Mustafa Çakan , Kübra Öztürk

https://doi.org/10.16948/zktipb.590889

Öz

Amaç:
Juvenil idiyopatik artrit (JİA) tüm dünyada en sık gözlenen çocukluk çağı
romatizmal hastalığıdır. Tek bir hastalık olmayıp alt gruplardan oluşmaktadır.
Kas iskelet sistemi dışında üveit şeklinde göz tutulumu önemli bir morbidite
nedenidir. Çalışmamızın amacı kliniklerimizde takip edilen JİA hastaların alt
tip dağılımını ve üveit sıklığını saptamaktır.

Metod:
Kliniklerimizde JİA tanısı ile takip ve tedavi edilen tüm hastaların dosyaları
geriye dönük olarak taranmıştır.

Bulgular: Çalışmamıza
264 JİA hastası dahil edilmiştir. Hastaların %54.9’u kız iken %45.1’i erkek idi
ve ortalama takip süresi 13.8 ± 5.8 ay idi. JİA alt tip dağılımına bakıldığında
en sık oligoartiküler JİA (%42.4) gözlenmekte idi. Entezit ilişkili artrit (%21.6)
ikinci sırada iken diğer JİA alt tip dağılımı şu şekilde idi; sistemik JİA
(%13.6), romatoid faktör (RF) negatif poliartiküler JİA (%10.2), RF pozitif
poliartiküler JİA (%9.5), psoriatik artrit (%1.9) ve sınıflandırılamayan artrit
(%0.8). Üveit toplam 23 hastada (%8.7) gözlenmiş olup üveit hastalarının
%91.3’ü oligoartiküler JİA grubunda idi. Sistemik JİA hastalarının %13.8’inde
makrofaj aktivasyon sendromu gözlendi. Son kontroldeki hastalık aktivitesine
bakıldığında hastaların %18.6’sı aktif iken %81.4’ü remisyonda takip
edilmekteydi.

Sonuç: Ülkemizde
en sık gözlenen JİA alt tipi diğer ülkelerde olduğu gibi oligoartiküler JİA’dır.
Ancak batı ülkelerinden farklı olarak ikinci en sık gözlenen alt tip entezit
ilişkili artrittir. Ülkemiz JİA hastalarının diğer bir farkı da, JİA ilişkili
üveitin daha az gözlenmesidir. Oligoartiküler JİA üveitin en sık gözlendiği alt
gruptur. Güncel tedavi seçeneklerinin artması ile hastaların büyük çoğunluğunda
hastalık remisyonu sağlanabilmektedir.

Anahtar Kelimeler

juvenile idiopatik artrit, üveit

Subtype distribution and frequency of uveitis in Southeastern Anatolian children with juvenile idiopathic arthritis

Öz

Aim:
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of
childhood in the world. It is not a single disease rather composed of distinct subtypes.
Apart from musculoskeletal complications, uveitis is one of the major causes of
morbidity in JIA. The aim of this study was to demonstrate subtype distribution
and frequency of uveitis in JIA.

Method:
The study was conducted in two pediatric rheumatology centers of Southeastern
part of Turkey.

Results: The
cohort consisted of 264 children with slightly female predominance (females:
54.9%, males: 45.1%). Mean duration of follow-up was 13.8 ± 5.8 months. The
most common subtype was oligoarticular JIA (42.4%) followed by enthesitis
related arthritis (21.6%). The distribution of other subtypes were as follows;
systemic JIA (13.6%), rheumatoid factor (RF) negative polyarticular JIA (10.2%),
RF positive polyarticular JIA (9.5%), psoriatic arthritis (1.9%) and
unclassified arthritis (0.8%). The frequency of uveitis was 8.7% and 91.3% of
the patients with uveitis had oligoarticular JIA. Macrophage activation
syndrome was observed in 13.8% of systemic JIA patients. While 18.6% of the
patients had active disease at the time of enrollment, 81.4% had remission.

Conclusion:
As in other parts of the world, oligoarticular JIA is the most common subtype
in our country. But, in contrast to western countries, enthesitis related
arthritis is the second most common subtype in Turkey. The frequency of uveitis
is low in Turkish JIA children that is another major difference from the
western countries and oligoarticular JIA is the most common subtype associated
with uveitis. With the introduction of newer treatment modalities, remission is
an achievable goal in most of the JIA patients.

Anahtar Kelimeler

juvenile idiopathic arthritis, uveitis

Kaynakça

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