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Estrogen and progesterone expression in endometrial hyperplasia and carcinoma

Year 2003, Volume: 34 Issue: 3, 5 - 8, 01.04.2003

Gözde Kır Handan Çetiner Ayşe Gürbüz

Abstract

Objective: To evaluate estrogen and progesteron receptor expression in endometrial hyperplasia and carcinoma . Material and Method: In parafin-embedded specimens from 28 patients with endometrial hyperplasia and from 29 patients with endometrial carcinoma , estrogen and progesterone receptors were analysed by immunohistochemical method Results: Estrogen receptor expression was identified 71,4%(20/28) in endometrialhyperplasias and 17,2%(5/29) in endometrial carcinomas(p

Keywords

Endometrial Hyperplasia Endometrial Neoplasms Receptors Progesterone Immunohistochemistry Receptors Estrogen

References

  • 1. Huang SJ,Cheng L,Lewin J,Fu YS. Immunohistochemical estrogen receptor assessment in hyperplastic, neoplastic and physiologic endometria. Path Res 1991; 187: 487-95
  • 2. Gambrell RD, Bagnel CA, Green Blatt RB. Role of estrogen and progesterone in the etiology and prevention of endometrial cancer: review. Am J Obstet Gynecol 1983; 146: 696-707
  • 3. Carcangiu ML, Chambers JT, Vaynick IM, Pirro M, Schwartz PE. Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Part I: clinical and histologic correlations. Am J Clin Pathol 1990; 94:247-54
  • 4. Creasman WT, Soper JT, McCarty KS Jr, McCarty KS SR, Hinshaw W, Clarke-Pearson DL. Influence of cytoplasmic steroid receptor conteent on prognosis of early stage endometrial carcinoma. Am J Obatet Gynecol 1985; 151: 922-32
  • 5. Palmer DC, Muir IM, Alexander AI, Cauchi M, Bennett RC, Quinn MA. The prognostic importance of steroid receptors in endometrial carcinoma. Obstet Gynecol 1988; 72: 388-93
  • 6. Snijders MP, De Goeij AF, Koudstal J, Rousch MJ, Scheres HM, Stot JE, Bosnian FT. Is immunohistochemical analysis of estrogen and progesterone receptors in endometrial carcinoma superior to the radioligand binding assay? J Pathol 1990; 161: 129-35
  • 7. Creasman WT. Prognostic significance of hormone receptors in endometrial cancer. Cancer 1993; 71(4 Suppl): 1467-70
  • 8. Vecek N, Nola M, Marusic et al. Prognostic value of steroid hormone receptors concentration in patients with endometrial carcinoma. Acta Obstet Gynecol Scand 1994; 73: 730-3
  • 9. Konski AA, Domenico D, Irving D et al. Clinicopathologic correlation of DNA flow cytometric content analysis (DFCA), surgical staging and estrogen/progesterone receptor status in endometrial adenocarcinoma. Am J Clin Oncol 1996; 19: 164-8
  • 10. Fukuda K, Mori M, Uchiyama M, Iwai K, Iwasaka T, Sugimori H. Prognostic significance of progesterone receptor immunohistochemistry in endometrial carcinoma. Gynecol Oncol 1998; 69: 220-5
  • 11. Sivridis E, Giatromanolaki A, Koukourakis M, Anastasiadis P. Endometrial carcinoma: association of steroid hormone receptor expression eith low angiogenesis and bcl-2 expression. VircowsArch 2001; 438: 470-7
  • 12. Brustein S, Fructer R, Greene GL, Pertschuk LP. Immunocytochemical assay of progesterone receptors in paraffin embedded specimens of endometrial carcinoma and hyperplasia: a preliminary evaluation. Mod Pathol 1989; 2: 449- 55
  • 13. Bergeron C, Ferenzy A, Toft DO, Shyamala G. Immunocytochemical study of receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res. 1988; 48: 6132-6. 14. Snijders MP, de Goeij AF, Koudstaal J, Thunriissen EB, de Haan J, Bosman FT. Oestrogen and progesterone receptor imunocytochemistry in human hyperplastic and neoplastic endometrium. J Pathol 1992; 166: 171-7
  • 15. Papadimitriou CS, Athanasiadou S, Stylianidou A, Bai MK, Demoliatis J, Stehanou DG. Immunohistochemical detection of estrogen receptors on paraffin sections of normal, hyperplastic and carcinomatous endometrium. Oncol 1992; 49: 196-202.

Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu

Year 2003, Volume: 34 Issue: 3, 5 - 8, 01.04.2003

Gözde Kır Handan Çetiner Ayşe Gürbüz

Abstract

Amaç: Endometrial hiperplazi ve karsinomlarda Östrojen ve progesteron ekşpresyonlarını değerlendirmek. Materyal ve Metod : 28 adet endometrial hiperplazi ve 29 adet endometrial karsinom içeren parafin blokda immunhistokimyasal yöntemle Östrojen ve progesteron reseptörleri çalışıldı. Bulgular : Endometrial hiperplazili olguların % 71.4'ünde (20/28), endometrialkarsinomlu olguların % 17.2'sinde (5/29) Östrojen reseptör ekspresyonu saptandı (p

Keywords

Endometriyum hiperplazisi Endometriyum neoplazmları Reseptörler progesteron İmmünohistokimya Reseptörler östrojen

References

  • 1. Huang SJ,Cheng L,Lewin J,Fu YS. Immunohistochemical estrogen receptor assessment in hyperplastic, neoplastic and physiologic endometria. Path Res 1991; 187: 487-95
  • 2. Gambrell RD, Bagnel CA, Green Blatt RB. Role of estrogen and progesterone in the etiology and prevention of endometrial cancer: review. Am J Obstet Gynecol 1983; 146: 696-707
  • 3. Carcangiu ML, Chambers JT, Vaynick IM, Pirro M, Schwartz PE. Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Part I: clinical and histologic correlations. Am J Clin Pathol 1990; 94:247-54
  • 4. Creasman WT, Soper JT, McCarty KS Jr, McCarty KS SR, Hinshaw W, Clarke-Pearson DL. Influence of cytoplasmic steroid receptor conteent on prognosis of early stage endometrial carcinoma. Am J Obatet Gynecol 1985; 151: 922-32
  • 5. Palmer DC, Muir IM, Alexander AI, Cauchi M, Bennett RC, Quinn MA. The prognostic importance of steroid receptors in endometrial carcinoma. Obstet Gynecol 1988; 72: 388-93
  • 6. Snijders MP, De Goeij AF, Koudstal J, Rousch MJ, Scheres HM, Stot JE, Bosnian FT. Is immunohistochemical analysis of estrogen and progesterone receptors in endometrial carcinoma superior to the radioligand binding assay? J Pathol 1990; 161: 129-35
  • 7. Creasman WT. Prognostic significance of hormone receptors in endometrial cancer. Cancer 1993; 71(4 Suppl): 1467-70
  • 8. Vecek N, Nola M, Marusic et al. Prognostic value of steroid hormone receptors concentration in patients with endometrial carcinoma. Acta Obstet Gynecol Scand 1994; 73: 730-3
  • 9. Konski AA, Domenico D, Irving D et al. Clinicopathologic correlation of DNA flow cytometric content analysis (DFCA), surgical staging and estrogen/progesterone receptor status in endometrial adenocarcinoma. Am J Clin Oncol 1996; 19: 164-8
  • 10. Fukuda K, Mori M, Uchiyama M, Iwai K, Iwasaka T, Sugimori H. Prognostic significance of progesterone receptor immunohistochemistry in endometrial carcinoma. Gynecol Oncol 1998; 69: 220-5
  • 11. Sivridis E, Giatromanolaki A, Koukourakis M, Anastasiadis P. Endometrial carcinoma: association of steroid hormone receptor expression eith low angiogenesis and bcl-2 expression. VircowsArch 2001; 438: 470-7
  • 12. Brustein S, Fructer R, Greene GL, Pertschuk LP. Immunocytochemical assay of progesterone receptors in paraffin embedded specimens of endometrial carcinoma and hyperplasia: a preliminary evaluation. Mod Pathol 1989; 2: 449- 55
  • 13. Bergeron C, Ferenzy A, Toft DO, Shyamala G. Immunocytochemical study of receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res. 1988; 48: 6132-6. 14. Snijders MP, de Goeij AF, Koudstaal J, Thunriissen EB, de Haan J, Bosman FT. Oestrogen and progesterone receptor imunocytochemistry in human hyperplastic and neoplastic endometrium. J Pathol 1992; 166: 171-7
  • 15. Papadimitriou CS, Athanasiadou S, Stylianidou A, Bai MK, Demoliatis J, Stehanou DG. Immunohistochemical detection of estrogen receptors on paraffin sections of normal, hyperplastic and carcinomatous endometrium. Oncol 1992; 49: 196-202.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Gözde Kır This is me

Handan Çetiner This is me

Ayşe Gürbüz This is me

Publication Date April 1, 2003
Published in Issue Year 2003 Volume: 34 Issue: 3

Cite

APA Kır, G., Çetiner, H., & Gürbüz, A. (2003). Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu. Zeynep Kamil Tıp Bülteni, 34(3), 5-8. https://doi.org/10.16948/zktb.76391
AMA Kır G, Çetiner H, Gürbüz A. Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu. Zeynep Kamil Tıp Bülteni. April 2003;34(3):5-8. doi:10.16948/zktb.76391
Chicago Kır, Gözde, Handan Çetiner, and Ayşe Gürbüz. “Endometrial Hiperplazi Ve Karsinomlarda östrojen Ve Progesteron reseptür Ekspresyonu”. Zeynep Kamil Tıp Bülteni 34, no. 3 (April 2003): 5-8. https://doi.org/10.16948/zktb.76391.
EndNote Kır G, Çetiner H, Gürbüz A (April 1, 2003) Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu. Zeynep Kamil Tıp Bülteni 34 3 5–8.
IEEE G. Kır, H. Çetiner, and A. Gürbüz, “Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu”, Zeynep Kamil Tıp Bülteni, vol. 34, no. 3, pp. 5–8, 2003, doi: 10.16948/zktb.76391.
ISNAD Kır, Gözde et al. “Endometrial Hiperplazi Ve Karsinomlarda östrojen Ve Progesteron reseptür Ekspresyonu”. Zeynep Kamil Tıp Bülteni 34/3 (April 2003), 5-8. https://doi.org/10.16948/zktb.76391.
JAMA Kır G, Çetiner H, Gürbüz A. Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu. Zeynep Kamil Tıp Bülteni. 2003;34:5–8.
MLA Kır, Gözde et al. “Endometrial Hiperplazi Ve Karsinomlarda östrojen Ve Progesteron reseptür Ekspresyonu”. Zeynep Kamil Tıp Bülteni, vol. 34, no. 3, 2003, pp. 5-8, doi:10.16948/zktb.76391.
Vancouver Kır G, Çetiner H, Gürbüz A. Endometrial hiperplazi ve karsinomlarda östrojen ve progesteron reseptür ekspresyonu. Zeynep Kamil Tıp Bülteni. 2003;34(3):5-8.