ANTIBACTERIAL CHARACTERISTICS OF NANOFIBER STRUCTURES OBTAINED BY BENZALKONIUM CHLORIDE ADDITIVE POLY (VINYL ALCOHOL)/GELATIN
Öz
Polyvinyl
alcohol (PVA) is a hydrophilous and semi-crystallized. It has attracted much
relevancy due to its pretty chemical endurance, fine thermal determination,
decent physical specialities, wonderful bio-compatibility and cheapness.
Gelatin (G) is a natural polymer and that are interesting materials for
biomedical applications. Electrospinning is a simple method that provides very
porous nanofiber production with high surface area. It is possible to produce
biomedical, filtration, energy storage and protective materials by using
electrospinning method. Benzalkonium chloride (BAC) is a kind of anti-microbial
cationic surface-active agent, which has been pretty used in merchant wound
dressings and has a powerful status toward Gr+ bacteria.
In this study, nanofibers were
produced from electrospinning of BAC, PVA and G containing solutions at various
concentrations. The fibers of obtained nanofiber structure were uniform,
continuous and intensive. The optimum parameters in terms of good mechanical
and antibacterial properties were determined. S2 sample, electrospun from 11.63% PVA + 1.0% G +1.0% BAC
containing solution, had the best morphological and mechanical properties due
to having the thinnest fiber diameter (51±13nm) and the highest vertical
strength (4.299MPa) and horizontal strength (4.058MPa). It also had antibacterial
activity against all the bacteria tested (E. coli,
P. aeruginosa, B. subtilis and S. aureus). Due to owning
good mechanical and antibacterial properties, S2 sample can have many uses in
medical sector.
Anahtar Kelimeler
Electrospinning poly(vinyl alcohol) gelatin benzalkonium chloride antibacterial nanofiber
Kaynakça
- Liu, Haifeng, Ding, Xili, Zhou, Gang, Li, Ping, Wei, Xing, Fan, Yubo, 2013, Electrospinning of nano fibers tissue engineering applications, Hindawi Publishing Corporation Journal of Nanomaterials
- Karakaş, H., 2015, Electrospinning of nanofibers and their applications, 7. Framework Programme
- Bhardwaj, Nandana, Kundu, Subhas. C., Electrospinning: A fascinating fiber fabrication technique, Biotecnology Advances 28, 2010
- Supaphol, Pitt, Chuangchote, Surawut, On the electrospinning of polyvinyl alcohol nanofiber mats: A revisit, Vol.108, 2008, Journal of Applied Polymer Science
- Siridamrong, P., Swasdison, S., Thamrongananskul, N., 2015, Preparation and characterization of polymer blends from Nang noi Srisaket 1 silk fibroin, gelatin, and chitosan nanofiber mats using formic acid solution, Vol.659, Key Engineering Materials
- Topuz, Fuat, Uyar, Tamer, 2017, Electrospinning of gelatin with tunable fiber morphology from round to flat/ribbon, Materials Science and Engineering, C 80
- Elder R.L., 1989, “Final report on the safety assessment of benzalkonium chloride” Journal of the American College of Toxicology, 8 (4), pp. 589-625
- Khan, Adnan Hossain, Libby, Mark, Winnick, Daniel, Palmer, John, Sumarah, Mark, Ray, Madhumita B., Macfie, S. M., Uptake and phytotoxic effect of benzalkonium chlorides in Lepidium sativum and Lactuca sativa, Journal of Environmental Management, 206, 2018
- You, Young, Lee, Seung Jin, Min, Buyong-Mu, Park, Won Ho, Effect of solution properties on nanofibrous structure of electrospun poly (lactic-co-glycolic acid), 99 1214–1221, 2006, Journal of Applied Polymer Science
- Tong, Ho Wang, Wang, Min, Electrospinning of poly(hydroxybutyrate-co-hyroxyvalerate) fibrous scaffolds for tissue engineering application: effects of electrospinning parameters and solution properties, B 50 1535–1558, 2011, Journal of Macromolecular Science
- Kim, Sung Jin, Nam, Young Sik, Rhee, Do Mook, Park, Hyun-Sul, Park, Won Ho, 2007, Preparation and characterization of antimicrobial polycarbonate nanofibrous membrane, European Polymer Journal, 43 3146–3152
- Arumugam, Ganesh Kumar, Khan, Sourabh, Heiden, Patricia A., Comparison of the effects of an ionic liquid and other salts on the properties of electrospun fibers, 2-poly(vinyl alcohol). Macromol. Mater. Eng. 294 45–53, 2009
Öz
Poli (vinil alkol) (PVA), iyi kimyasal dayanımı, iyi termal kararlılığı, iyi fiziksel özellikleri, mükemmel biyouyumluluğu ve ucuzluğu nedeniyle çok dikkat çeken hidrofilik, yarı kristalli bir polimerdir. Jelatin (G) biyomedikal uygulamalar için ilginç ve doğal bir polimerdir. Elektroeğirme, yüksek yüzey alanına sahip çok gözenekli nano elyaf üretimi sağlayan basit bir yöntemdir. Elektrospinning yöntemi kullanılarak biyomedikal, filtrasyon, enerji depolama ve koruyucu malzemeler üretmek mümkündür. Benzalkonyum klorür (BAC), ticari yara sargısında yaygın olarak kullanılan ve Gram-pozitif bakterilere karşı güçlü bir role sahip olan bir tür antimikrobiyal katyonik yüzey aktif malzemedir. Bu çalışmada, çeşitli konsantrasyonlarda BAC, PVA ve G içeren çözeltilerin nano lifler üretilmiştir. Elde edilen nano lif yapısının lifleri homojen, sürekli ve yoğundur. İyi mekanik ve antibakteriyel özellikler açısından optimum parametreler belirlenmiştir. 11.63% PVA + 1.0% G +1.0% BAC içeren S2 örneği en iyi morfolojik ve mekanik özellikler göstermesinin yanında en ince elyaf çapına (51 ± 13nm) ve en yüksek dikey dayanıma (4.299MPa) ve yatay dayanıma (4.058MPa) sahiptir. Ayrıca test edilen tüm bakterilere (E. coli, P. aeruginosa, B. subtilis ve S. aureus) karşı antibakteriyel aktiviteye sahiptir. İyi mekanik ve antibakteriyel özelliklere sahip olması nedeniyle, S2 örneğinin tıbbi sektörde birçok kullanımı olabileceği sonucuna ulaşılmıştır.
Anahtar Kelimeler
Elektroeğirme PolivinilAlkol PVA Benzalkonyum Klorür BAC Antibakteriyel Nanolif
Kaynakça
- Liu, Haifeng, Ding, Xili, Zhou, Gang, Li, Ping, Wei, Xing, Fan, Yubo, 2013, Electrospinning of nano fibers tissue engineering applications, Hindawi Publishing Corporation Journal of Nanomaterials
- Karakaş, H., 2015, Electrospinning of nanofibers and their applications, 7. Framework Programme
- Bhardwaj, Nandana, Kundu, Subhas. C., Electrospinning: A fascinating fiber fabrication technique, Biotecnology Advances 28, 2010
- Supaphol, Pitt, Chuangchote, Surawut, On the electrospinning of polyvinyl alcohol nanofiber mats: A revisit, Vol.108, 2008, Journal of Applied Polymer Science
- Siridamrong, P., Swasdison, S., Thamrongananskul, N., 2015, Preparation and characterization of polymer blends from Nang noi Srisaket 1 silk fibroin, gelatin, and chitosan nanofiber mats using formic acid solution, Vol.659, Key Engineering Materials
- Topuz, Fuat, Uyar, Tamer, 2017, Electrospinning of gelatin with tunable fiber morphology from round to flat/ribbon, Materials Science and Engineering, C 80
- Elder R.L., 1989, “Final report on the safety assessment of benzalkonium chloride” Journal of the American College of Toxicology, 8 (4), pp. 589-625
- Khan, Adnan Hossain, Libby, Mark, Winnick, Daniel, Palmer, John, Sumarah, Mark, Ray, Madhumita B., Macfie, S. M., Uptake and phytotoxic effect of benzalkonium chlorides in Lepidium sativum and Lactuca sativa, Journal of Environmental Management, 206, 2018
- You, Young, Lee, Seung Jin, Min, Buyong-Mu, Park, Won Ho, Effect of solution properties on nanofibrous structure of electrospun poly (lactic-co-glycolic acid), 99 1214–1221, 2006, Journal of Applied Polymer Science
- Tong, Ho Wang, Wang, Min, Electrospinning of poly(hydroxybutyrate-co-hyroxyvalerate) fibrous scaffolds for tissue engineering application: effects of electrospinning parameters and solution properties, B 50 1535–1558, 2011, Journal of Macromolecular Science
- Kim, Sung Jin, Nam, Young Sik, Rhee, Do Mook, Park, Hyun-Sul, Park, Won Ho, 2007, Preparation and characterization of antimicrobial polycarbonate nanofibrous membrane, European Polymer Journal, 43 3146–3152
- Arumugam, Ganesh Kumar, Khan, Sourabh, Heiden, Patricia A., Comparison of the effects of an ionic liquid and other salts on the properties of electrospun fibers, 2-poly(vinyl alcohol). Macromol. Mater. Eng. 294 45–53, 2009
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Mühendislik |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 20 Aralık 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 31 - Özel Sayı II: |