Is there a relationship between the severity of atherosclerosis and the development of colon cancer?

Öz

Background and Aims: Colorectal cancer and atherosclerosis share common risk factors, such as male gender, diabetes mellitus, smoking, and obesity. We investigated the relationship between colorectal cancer and atherosclerosis of the abdominal aorta to understand the importance of atherosclerosis in determining the risk of colorectal cancer. Materials and Methods: Sixty-three male patients with abdominal computed tomography examinations performed 3 months before and 3 months after the diagnosis were included in the study after being histopathologically diagnosed with colorectal cancer. In addition, 56 male subjects who had an abdominal computed tomography examination for various reasons comprised the control group. Atherosclerosis observed on the anterior and posterior wall of the aorta at the level of the L2, L3, and L4 vertebra was scored on sagittal reformatted abdominal computed tomography images. The abdominal aortic atherosclerosis scores of the subjects with colorectal cancer and the control group were compared. Results: The mean age of the patient group with colorectal cancer was 63.95 ± 11.1 years, and the mean age of the control group was 64.79 ± 11.5 years. The mean abdominal aorta atherosclerosis score (5.44 ± 3.7) was significantly higher in the patients with colorectal cancer than in the control group (3.86 ± 2.6) (p < 0.05). Conclusion: Abdominal aorta atherosclerosis was more severe in patients with colorectal cancer than in the control group. Valuable information on the risk of colorectal cancer development can be obtained by scoring aortic atherosclerosis on abdominal computed tomography scans performed for various reasons.

Anahtar Kelimeler

• Atherosclerosis
• colon cancer
• abdominal aorta

Ateroskleroz yaygınlığı ile kolon kanseri gelişimi arasında ilişki var mı?

Öz

Giriş ve Amaç: Kolorektal kanser ve ateroskleroz; erkek cinsiyet, Diabetes Mellitus, sigara içme ve obezite gibi yaygın risk faktörlerini paylaşmaktadır. Aterosklerozun kolorektal kanser riskini belirlemede önemini anlamak üzere kolorektal kanser ve abdominal aorta aterosklerozu arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Kolorektal kanser tanısı almış erkek hastaların tanı aldığı dönemdeki abdominal bilgisayarlı tomografi incelemeleri değerlendirilmiştir. Histopatolojik olarak kolorektal kanser tanısı konmasından 3 ay önce ve 3 ay sonraki dönem aralığında yapılmış olan abdominal bilgisayarlı tomografi incelemeleri olan 63 erkek hasta çalışmaya dahil edilmiştir. Ayrıca çeşitli nedenlerle abdominal bilgisayarlı tomografi incelemesi yapılmış 56 erkek denek kontrol grubu olarak değerlendirilmiştir. Abdominal bilgisayarlı tomografi incelemelerinde sagittal reformat görüntüler üzerinden, L2, L3 ve L4 vertebralar seviyesinde, aorta ön ve arka duvarında izlenen ateroskleroz skorlandırılmıştır. Kolorektal kanseri bulunan ve kontrol grubu deneklerin abdominal aorta ateroskleroz skorları karşılaştırılmıştır. Bulgular: Kolorektal kanseri bulunan hasta grubunun yaş ortalaması 63.95 ± 11.1, kontrol grubu deneklerin yaş ortalaması 64.79 ± 11.5 idi. Kolorektal kanseri olanlarda abdominal aorta ateroskleroz skor ortalaması (5.44 ± 3.7), kontrol grubuna (3.86 ± 2.6) göre anlamlı düzeyde daha yüksekti (p <0.05). Sonuç: Bu çalışmada, kolorektal kanseri bulunan olgularda abdominal aortada ateroskleroz şiddetinin kontrol grubuna kıyasla daha yüksek olduğu görüldü. Değişik nedenlerle yapılan abdominal bilgisayarlı tomografi incelemelerinde aorta ateroskleroz skorlamasının yapılması ile kolorektal kanser gelişim riski bakımından değerli bilgi edinilebileceğini düşünmekteyiz.

Anahtar Kelimeler

• Ateroskleroz
• kolon kanseri
• abdominal aorta

Kaynakça

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