Is there a relationship between the severity of atherosclerosis and the development of colon cancer?

Yıl 2021, Cilt: 20 Sayı: 1, 44 - 48, 14.05.2021

Ahmet Vural

https://doi.org/10.17941/agd.931455

Cited By: 1

Öz

Background and Aims: Colorectal cancer and atherosclerosis share common risk factors, such as male gender, diabetes mellitus, smoking, and obesity. We investigated the relationship between colorectal cancer and atherosclerosis of the abdominal aorta to understand the importance of atherosclerosis in determining the risk of colorectal cancer. Materials and Methods: Sixty-three male patients with abdominal computed tomography examinations performed 3 months before and 3 months after the diagnosis were included in the study after being histopathologically diagnosed with colorectal cancer. In addition, 56 male subjects who had an abdominal computed tomography examination for various reasons comprised the control group. Atherosclerosis observed on the anterior and posterior wall of the aorta at the level of the L2, L3, and L4 vertebra was scored on sagittal reformatted abdominal computed tomography images. The abdominal aortic atherosclerosis scores of the subjects with colorectal cancer and the control group were compared. Results: The mean age of the patient group with colorectal cancer was 63.95 ± 11.1 years, and the mean age of the control group was 64.79 ± 11.5 years. The mean abdominal aorta atherosclerosis score (5.44 ± 3.7) was significantly higher in the patients with colorectal cancer than in the control group (3.86 ± 2.6) (p < 0.05). Conclusion: Abdominal aorta atherosclerosis was more severe in patients with colorectal cancer than in the control group. Valuable information on the risk of colorectal cancer development can be obtained by scoring aortic atherosclerosis on abdominal computed tomography scans performed for various reasons.

Anahtar Kelimeler

Atherosclerosis, colon cancer, abdominal aorta

Ateroskleroz yaygınlığı ile kolon kanseri gelişimi arasında ilişki var mı?

Öz

Giriş ve Amaç: Kolorektal kanser ve ateroskleroz; erkek cinsiyet, Diabetes Mellitus, sigara içme ve obezite gibi yaygın risk faktörlerini paylaşmaktadır. Aterosklerozun kolorektal kanser riskini belirlemede önemini anlamak üzere kolorektal kanser ve abdominal aorta aterosklerozu arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Kolorektal kanser tanısı almış erkek hastaların tanı aldığı dönemdeki abdominal bilgisayarlı tomografi incelemeleri değerlendirilmiştir. Histopatolojik olarak kolorektal kanser tanısı konmasından 3 ay önce ve 3 ay sonraki dönem aralığında yapılmış olan abdominal bilgisayarlı tomografi incelemeleri olan 63 erkek hasta çalışmaya dahil edilmiştir. Ayrıca çeşitli nedenlerle abdominal bilgisayarlı tomografi incelemesi yapılmış 56 erkek denek kontrol grubu olarak değerlendirilmiştir. Abdominal bilgisayarlı tomografi incelemelerinde sagittal reformat görüntüler üzerinden, L2, L3 ve L4 vertebralar seviyesinde, aorta ön ve arka duvarında izlenen ateroskleroz skorlandırılmıştır. Kolorektal kanseri bulunan ve kontrol grubu deneklerin abdominal aorta ateroskleroz skorları karşılaştırılmıştır. Bulgular: Kolorektal kanseri bulunan hasta grubunun yaş ortalaması 63.95 ± 11.1, kontrol grubu deneklerin yaş ortalaması 64.79 ± 11.5 idi. Kolorektal kanseri olanlarda abdominal aorta ateroskleroz skor ortalaması (5.44 ± 3.7), kontrol grubuna (3.86 ± 2.6) göre anlamlı düzeyde daha yüksekti (p <0.05). Sonuç: Bu çalışmada, kolorektal kanseri bulunan olgularda abdominal aortada ateroskleroz şiddetinin kontrol grubuna kıyasla daha yüksek olduğu görüldü. Değişik nedenlerle yapılan abdominal bilgisayarlı tomografi incelemelerinde aorta ateroskleroz skorlamasının yapılması ile kolorektal kanser gelişim riski bakımından değerli bilgi edinilebileceğini düşünmekteyiz.

Anahtar Kelimeler

Ateroskleroz, kolon kanseri, abdominal aorta

Kaynakça

• 1. American Cancer Society. Colorectal Cancer Facts & Figures 2020-2022. Atlanta, Ga: American Cancer Society; 2020.
• 2. Yiğit T. Kolonoskopi deneyimlerimiz: Ardışık 983 hastanın irdelenmesi. Kolon Rektum Hast Derg 2007;17:154-9.
• 3. Tamer A, Korkut E, Korkmaz U, Akcan Y. Alt gastrointestinal endoskopi sonuçlarımız: Düzce bölgesi. The Medical Journal of Kocatepe 2005;6:29-31.
• 4. Heitman SJ, Ronksley PE, Hilsden RJ, et al. Prevalence of adenomas and colorectal cancer in average risk individuals: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2009;7:1272-8.
• 5. Eddy DM. Screening for colorectal cancer. Ann Intern Med 1990;113:373-84.
• 6. Chan AO, Jim MH, Lam KF, et al. Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease. JAMA 2007;298:1412-9.
• 7. Correa P, Strong JP, Johnson WD, et al. Atherosclerosis and polyps of the colon. Quantification of precursors of coronary heart disease and colon cancer. J Chronic Dis 1982;35:313-20.
• 8. Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res 1988;48:4399-404.
• 9. Neugut AI, Jacobson JS, Sherif G, et al. Coronary artery disease and colorectal neoplasia. Dis. Colon Rectum. 1995;38:873-7.
• 10. Neugut AI, Rosenberg DJ, Ahsan H, et al. Association between coronary heart disease and cancers of the breast, prostate, and colon. Cancer Epidemiol Biomarkers Prev 1998;7:869-73.
• 11. Chan AO, Lam KF, Tong T, et al. Coexistence between colorectal cancer/adenoma and coronary artery disease: results from 1382 patients. Aliment Pharmacol Ther 2006;24:535-9.
• 12. Liao KF, Lai HC, Lai SW, Cheng KC, Lin CH. Association between rectosigmoid adenomas and cardiovascular risk factors: a hospital-based, cross-sectional study. Ann Acad Med Singap 2009;38:630-6.
• 13. Stemmermann GN, Heilbrun LK, Nomura A, Yano K, Hayashi T. Adenomatous polyps and atherosclerosis: an autopsy study of Japanese men in Hawaii. Int J Cancer 1986;38:789-94.
• 14. Libby P: Inflammation in atherosclerosis. Nature 2002;420:868-74.
• 15. Tsilidis KK, Branchini C, Guallar E, et al. C-reactive protein and colorectal cancer risk: a systematic review of prospective studies. Int J Cancer 2008;123:1133-40.
• 16. Arber N, Levin B: Chemoprevention of colorectal neoplasia: the potential for personalized medicine. Gastroenterology 2008;134:1224-37.
• 17. Robinson SC, Coussens LM. Soluble mediators of inflammation during tumor development. Adv Cancer Res 2005;93:159-87.
• 18. Chapple KS, Cartwright EJ, Hawcroft G, et al. Localisation of cyclooxygenase-2 in human sporadic colorectal adenomas. Am J Pathol 2000;156:545-53.
• 19. Morand EF, Leech M, Bernhagen J. MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis. Nat Rev Drug Discov 2006;5:399-410.
• 20. Wilson JM, Coletta PL, Cuthbert RJ, et al. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 2005;129:1485-503.
• 21. Giovannucci E, Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 2007;132:2208-25.
• 22. Hull M, Kant P. Atherosclerosis and colorectal carcinogenesis: shared risk factors or common pathogenesis? Digestion 2010;81:16-7.
• 23. Yang SY, Kim YS, Chung SJ, et al. Association between colorectal adenoma and coronary atherosclerosis detected by CT coronary angiography in Korean men; a cross-sectional study. J Gastroenterol Hepatol 2010;25:1795-9.
• 24. Kauppila LI, Polak JF, Cupples LA, et al. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 1997;132:245-50.