Identification of the major phenolic compounds in Alcea setosa (Boiss.) Alef. and a systematic review of their chemotherapeutic activities

Öz

In this study, the aim was to determine potential chemotherapeutic agents with a phenolic structure in Alcea setosa (Boiss.) Alef. plant. In this context, solutions were obtained from various parts of the plant (flowers, leaves, seeds, and stems) using the infusion method with multiple solvents. These solutions were analyzed for phenolic compounds by LC-MS/MS. The major compounds in the plant parts were statistically determined (0.14≤ η2) according to the amount of identified phenolic compounds. As a result of the phytochemical analysis, 12 phenolic compounds were detected in the plant. The major phenolic compounds found in the plant parts were determined as follows: caffeic acid, fumaric acid, 4-hydroxybenzoic acid, hydroxycinnamic acid, kaempferol, luteolin, myricetin, naringenin, quercetin, syringic acid, and vanillic acid in the flower part; hydroxycinnamic acid, luteolin, resveratrol, and syringic acid in the leaf part; fumaric acid in the seed part; luteolin in the stem part. In the literature, it was seen that these compounds exhibit chemotherapeutic activity against 19 cancer types (bladder cancer, breast cancer, colorectal cancer, chronic myeloid leukemia, endometrial cancer, erythroleukemia, gastric cancer, glioblastoma multiforme, liver cancer, lung cancer, melanoma, neuroblastoma, oral cancer, ovarian cancer, pancreatic cancer, promyelocytic leukemia, prostate cancer, skin cancer, thyroid cancer). It can be suggested that, due to the potential chemotherapeutic agents found in the plant's flower, leaf, stem, and seed parts, these parts may serve as good material for future experimental research and drug development studies.

Anahtar Kelimeler

• Alcea setosa
• anticancer
• chemotherapeutic agent
• phenolic compound
• phytochemistry

Alcea setosa (Boiss.) Alef.'teki başlıca fenolik bileşiklerin tanımlanması ve kemoterapötik aktivitelerinin sistematik bir incelemesi

Öz

Bu çalışmada, Alcea setosa (Boiss.) Alef. bitkisinde fenolik yapıya sahip potansiyel kemoterapötik ajanların belirlenmesi amaçlanmıştır. Bu bağlamda, bitkinin çeşitli kısımlarından (çiçek, yaprak, tohum ve gövde) çoklu çözücüler kullanılarak infüzyon yöntemiyle çözeltiler elde edilmiştir. Bu çözeltiler, LC-MS/MS yöntemiyle fenolik bileşikler açısından analiz edilmiştir. Bitki kısımlarındaki başlıca bileşikler, tanımlanan fenolik bileşiklerin miktarına göre istatistiksel olarak (0.14≤ η2) belirlenmiştir. Fitokimyasal analiz sonucunda bitkide 12 fenolik bileşik tespit edilmiştir. Bitki kısımlarında bulunan başlıca fenolik bileşikler şu şekilde belirlenmiştir: çiçek kısmında kafeik asit, fumarik asit, 4-hidroksibenzoik asit, hidroksisinnamik asit, kaempferol, luteolin, mirisetin, naringenin, kuersetin, siringik asit ve vanilik asit; yaprak kısmında hidroksisinnamik asit, luteolin, resveratrol ve siringik asit; tohum kısmında fumarik asit; gövde kısmında ise luteolin. Literatürde, bu bileşiklerin 19 kanser türüne (mesane kanseri, meme kanseri, kolorektal kanser, kronik miyeloid lösemi, endometriyal kanser, eritrolösemi, mide kanseri, glioblastoma multiforme, karaciğer kanseri, akciğer kanseri, melanom, nöroblastoma, ağız kanseri, yumurtalık kanseri, pankreas kanseri, promyelositik lösemi, prostat kanseri, cilt kanseri, tiroid kanseri) karşı kemoterapötik aktivite gösterdiği görülmüştür. Bitkinin çiçek, yaprak, gövde ve tohum kısımlarında bulunan potansiyel kemoterapötik ajanlar nedeniyle, bu kısımların gelecekteki deneysel araştırmalar ve ilaç geliştirme çalışmaları için iyi birer materyal olarak kullanılabileceği öne sürülebilir.

Anahtar Kelimeler

• Alcea setosa
• antikanser
• fenolik bileşik
• fitokimya
• kemoterapötik ajan

Kaynakça

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