Astımlı Çocukların Serum D Vitamini ve Çinko Düzeyleri ile Klinik Bulguları Arasında Bir İlişki Var mı?

Yıl 2018, , 528 - 536, 27.12.2018

Zehra Şule Haskoloğlu , Demet Altun

https://doi.org/10.17098/amj.499653

Öz

Amaç: Vitamin D ve çinko eksikliğinin astım ile ilişkili olduğu bildirilmektedir. Bu çalışmada astımlı

çocukların klinik bulguları ile vitamin D ve çinko düzeyleri arasındaki ilişkiyi araştırmayı istedik.

Materyal ve Metot: Bu prospektif çalışmaya yaşları 5‐17 arasında değişen 149 astımlı ve 97 sağlıklı çocuk

dahil edildi. Tüm katılımcıların serum 25 hidroksivitamin D (25(OH)D) ve çinko düzeyleri ölçüldü, diyet

alışkanlıkları, bir yıldaki solunum yolu enfeksiyonu sıklıkları, hastane başvuruları ve güneş ışığına

maruziyet süreleri sorgulandı.

Bulgular: Astımlı çocukların serum D vitamini ve çinko düzeyleri sırasıyla (7,7±5,29 ng/ml), (64±16,3

mcg/dl) sağlıklı çocuklardan (12,3±12,87 ng/ml), (69±26,2 mcg/dl) belirgin şekilde düşük bulundu (p

<0,001) (p <0,015). Serum D vitamini düzeyinin 10ng/ml'nin altında olması ile enfeksiyon sıklığı arasında

ilişki bulunurken çinko düzeyi ile ilişki saptanmadı. Pulmoner fonksiyonlar, beslenme ile D vitamini

düzeyi arasında ilişki saptanmadı. Ancak güneşe maruziyet ile D vitamini düzeyi arasında bir ilişki

saptandı.

Sonuç: Sonuç: Bizim sonuçlarımız astımlı çocukların sağlıklı çocuklardan daha düşük D vitamini ve

çinko düzeyine sahip olduğunu göstermektedir. D vitamininin çok düşük düzeylerde olması artmış

enfeksiyon riski, daha çok tedavi ihtiyacı ve hastane yatışı ile ilişkili ulundu.

Anahtar Kelimeler

Astımlı çocuk, vitamin D düzeyi, çinko düzeyi, klinik bulgular

Is There a Relationship between Clinical Symptoms of Asthmatic Children and Serum Levels of Vitamin D and Zinc?

Öz

Objectives:
It is reported that deficiencies in vitamin D and zinc are associated with
asthma. In this study we aimed to investigate the relationship between clinic
findings of asthmatic children and vitamin D and zinc levels.
Materials and Methods: This
prospective study included a total of 149 asthmatics and 97 healthy children
with an age range of 5 to 17 years. All of the participants were evaluated for
serum levels of 25 -hydroxyvitamin D (25(OH)D) and zinc, dietary habits, the
rate of respiratory tract infections, hospital visits and levels of sunlight
exposure.
Results: Serum vitamin D and zinc
levels in asthmatic children (7.7±5.29 ng/ml), (64±16.3 mcg/dl) were
significantly lower than that in healthy children (12.3±12.87 ng/ml), (69±26.2
mcg/dl) (p< 0.015), respectively. A relationship was detected between the
frequency of infection and vitamin D level’s being <10ng/ml (p < 0.001),
while no relationship was detected between the frequency of infection and zinc
level. No relationship was detected between pulmonary function, nutrition and
the levels of vitamin D and zinc. However, a relationship was detected between
vitamin D levels and exposure to sunlight.
Conclusion: Our results showed that
asthmatic children had lower vitamin D and zinc levels than healthy children.
Very low levels of vitamin D were found to be associated with an increased rate
of infection and required more medication and hospitalization

Anahtar Kelimeler

Asthmatic children, level of vitamin D, level of zinc, clinical symptoms

Kaynakça

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