The Level of Thiol-Disulfide on Colorectal Cancer
Öz
Aim: This study aimed to evaluate total thiol (TT), disulfide (-S-S), and native thiol (-SH) concentrations as serum biomarkers in patients with colorectal cancer (CRC).
Materials and Methods: A total of 46 participants (23 patients with colorectal cancer and 23 healthy individuals) were included. Thiol/disulfide homeostasis tests (total thiol [TT], native thiol [-SH], and disulfide [-S-S]) were performed by a novel automated method. Ischemia modified albumin (IMA), albumin, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA-19-9), TT, -SH, and -S-S levels as well as disulfide/native thiol and disulfide/total thiol ratios were compared between the groups.
Results: In the colorectal cancer group, statistically significant difference was found in IMA, CEA, and CA-19-9, compared to the control group (p<0.05). There was no relationship between the thiol–disulfide parameters and tumor markers in the control group (p>0.05). There was no relationship between the thiol–disulfide parameters and IMA, albumin, CEA, and CA-19-9 levels in the colorectal cancer group (p>0.05).
Discussion and Conclusion: Our study shows that the serum concentrations of native -SH, -S-S, and TT do not link to colorectal cancer as a noninvasive biomarker.
Anahtar Kelimeler
Kaynakça
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