İki Alman Holştayn Buzağıda Atresia Ani, Hypospadia ve Gelişmemiş Dış Genital Organlar Olgusu

Yıl 2017, Cilt: 12 Sayı: 2, 195 - 202, 30.10.2017

Zafer Usta

https://doi.org/10.17094/ataunivbd.347977

Cited By: 1

Öz

Bu raporda, klinik, patolojik ve sitogenetik
muayenelerinin yapıldığı Atreziya ani, hypospadia ve gelişmemiş dış genital
organlar ile karakterize bir günlük erkek Alman Holştayn buzağı (HYP-AA) ile
Hypospadia ve rudumenter dış genital organlar ile karakterize altı aylık erkek
bir Alman Holştayn buzağı (HYP) sunulmuştur. İlk olguda (HYP-AA) anüs
oluşmamıştı. İdrar yolu perineuma açılmıştı; bunun sonucu olarak, kasık
bölgesinden idrar süzülüyordu. İkinci bulgu olarak, yaklaşık 10 cm'lik bir çapa
sahip olan anal bölgede bir vezikül oluşumu vardı. HYP-AA-nın anal bölgesinde
yapılan histopatolojik incelemede multifokal akut kanama ve yaygın ödemli
nekrotizan dermatit odaklar görüldü. Klinik olarak, interstisyel pnömoni ve
üretritis tespit edilmiştir. İkinci olguda ise (HYP), bir penil ve prepusyal
aplazi, ventral tarafı deri tarafından kaplanmamış bifid skrotum olgusu
görüldü. HYP-nin histopatolojik incelemesinde üretra epitelinde hiperplazi ve
lenf nodularında foliküler hiperplazi ve üretritis gözlemlendi. HYP-nin testisi
normal gelişmiş, ancak aktif spermatogenez görülmedi. HYP-AA için akrabalık
katsayısı % 0.684 ve HYP-için % 5.273 ve her iki buzağının babaları ortakdı.
Sonuç olarak iki olguda da meydana gelen konjenital anomaliler ortak boğa
tarafından iletilen mutasyonlara bağlı olabilir.

Anahtar Kelimeler

Atreziya ani, Hypospadia, Kalıtsal, Konjenital anomaly, Rudumenter dış genital organlar

Atresia Ani, Hypospadia and Rudimentary External Genitalia in Two German Holstein Calves

Öz

In the present report, clinical, pathological, and cytogenetic
examinations of a one-day-old male German Holstein calf with atresia ani,
hypospadia and rudimentary external genitalia (HYP-AA) and a six-months-old
male German Holstein calf with hypospadia and rudimentary external genitalia
(HYP) are presented. In the first case (HYP-AA), an anal orifice was missing.
The urethra opened in the perineum. Consequently, the inguinal region was
infiltrated with urine. A secondary finding was a vesicle at the anal area with
a diameter of approximately 10 cm. Histopathological examination of the anal
area of the HYP-AA-calf showed a necrotizing dermatitis with multifocal acute
bleedings and diffuse oedema. In addition, an interstitial pneumonia and
urethritis were identified. In the clinical examination of the second case
(HYP), a penile and preputial aplasia, an incomplete ventral covering by skin
and a bifid scrotum were found. Histopathological examination of the HYP-calf
revealed a urethritis with epithelial hyperplasia in the urethra and a
follicular hyperplasia of the lymph nodes. The HYP-calf had normally developed
testicles. However, there was no active spermatogenesis. The inbreeding
coefficient for the HYP-AA-calf was 0.684% and for the HYP-calf 5.273% and both
affected calves had one ancestor in common, a Holstein bull used in artificial
insemination. In conclusion the congenital anomalies of the two cases might be
due to mutations transmitted by the common ancestor.

Anahtar Kelimeler

Atresia ani, Congenital anomaly, Hereditary, Hypospadia, Rudimentary external genitalia

Kaynakça

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