Comparison of Clinical Effects of Propofol-Sevoflurane, Midazolam-Sevoflurane and Medetomidine-Ketamine-Sevoflurane Anesthesia in Rabbits

Yıl 2025, Cilt: 14 Sayı: 1, 9 - 15, 28.03.2025

Yahya Işık , Muharrem Erol

Öz

Objective: This study aimed to compare the clinical effects of propofol-sevoflurane (PS), midazolam-sevoflurane (MS), and medetomidine-ketamine-sevoflurane (MKS) anesthesia protocols in rabbits and to propose a safe and controlled alternative inhalation anesthesia technique using the endotracheal intubation method. Materials and Methods: The study was conducted on 30 white New Zealand rabbits (5 females and 5 males randomly selected per group) divided into three groups. In the PS group, propofol 7 mg/kg IV was administered; in the MS group, midazolam 0.3 mg/kg IM; and in the MKS group, medetomidine 0.3 mg/kg IM followed by ketamine 30 mg/kg IM. Subsequently, all groups received sevoflurane at 4% with 500 ml/kg/min oxygen. In all groups, anesthesia induction time, chewing reflex time (extubation time), righting reflex time, heart rate, respiratory rate, body temperature, and peripheral arterial hemoglobin saturation were determined. Results: During anesthesia, decreases in heart rate and body temperature were observed in all groups. Respiratory rate decreased during the first 30 minutes of anesthesia but increased again after the 45th minute. Conclusion: For both clinical and experimental procedures in rabbits, the propofol-sevoflurane combination is considered appropriate for less painful and short-term interventions, while the medetomidine-ketamine-sevoflurane combination is recommended for highly painful and long-term procedures.

Anahtar Kelimeler

Rabbit, Anesthesia, Propofol, Midazolam, Sevoflurane

Tavşanlarda Propofol-Sevofluran, Midazolam-Sevofluran ve Medetomidin-Ketamin-Sevofluran Anestezisinin Klinik Etkilerinin Karşılaştırılması

Öz

Amaç: Bu çalışmanın amacı, tavşanlarda propofol-sevofluran (PS), midazolam-sevofluran (MS) ve medetomidin-ketamin-sevofluran (MKS) anestezi protokollerinin tavşanlardaki klinik etkilerini karşılaştırmak ve tavşanlarda endotrakeal entübasyon tekniği ile güvenli ve kontrollü alternatif inhalasyon anestezisi tekniği önermektir. Gereç ve Yöntem: Çalışma, her bir grupta rastgele seçilen 5'i dişi, 5'i erkek 10 adet beyaz renkli Yeni Zelanda ırkı 30 adet tavşanda 3 grupta yapıldı. PS grubunda propofol 7 mg/kg IV, MS grubunda midazolam 0.3 mg/kg IM, MKS grubunda medetomidin 0.3 mg/kg IM ve ketamin 30 mg/kg IM uygulandı. Takiben tüm gruplarda tavşanlara sevofluran %4 olarak 500 ml/kg/dk oksijen ile uygulandı. Bütün gruplarda; anestezi indüksiyon süresi, çiğneme refleksi zamanı (ekstübasyon zamanı), doğrulma refleksi zamanı, dakikadaki kalp atım sayısı, solunum sayısı, vücut ısısı ve periferik arteriyel hemoglobin satürasyonu belirlendi. Bulgular: Çalışmadaki tüm gruplarda oluşan anestezi süresince kalp atım sayısı ve vücut ısısında düşüşler gözlendi. Solunum sayısında anestezinin ilk 30 dakikasında düşüşler gözlendi. Ancak, 45. dakikadan sonra tekrar yükseldi. Sonuç: Tavşanlarda yapılacak olan gerek deneysel gerekse klinik cerrahi uygulamalarda; az ağrılı ve kısa süreli girişimlerde propofol-sevofluran kombinasyonunun; çok ağrılı ve uzun süreli girişimlerde ise medetomidin-ketamin-sevofluran kombinasyonunun kullanılmasının uygun olacağı kanaatine varıldı.

Anahtar Kelimeler

Tavşan, Anestezi, Propofol, Midazolam, Sevofluran

Kaynakça

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