Fitoterapide doğal derin ötektik çözücülerin kullanımı

Aysu Günaydın; Mahfuz Elmastaş

doi:10.53445/batd.1906090

TR EN

Fitoterapide doğal derin ötektik çözücülerin kullanımı

Öz

Fitoterapi, bitkisel kökenli drogların ve bu drogların içerdiği biyolojik olarak aktif bileşiklerin hastalıkların önlenmesi ve tedavisinde kullanımını temel alan, kökeni geleneksel tıp uygulamalarına dayanan tamamlayıcı ve destekleyici bir tedavi yaklaşımıdır. Günümüzde fitoterapötik ürünlerin etkililiği ve güvenliliği yalnızca bitkisel materyalin türüne değil, aynı zamanda uygulanan ekstraksiyon yöntemine ve kullanılan çözücü sistemine de doğrudan bağlıdır. Geleneksel bitkisel ekstraksiyonlarda yaygın olarak tercih edilen organik çözücüler; toksisite, çevresel sürdürülebilirlik sorunları, sınırlı seçicilik ve çözücü kalıntısı riski gibi önemli dezavantajlar içermektedir. Bu nedenle, yeşil kimya ilkeleriyle uyumlu alternatif çözücü sistemlerine duyulan ihtiyaç giderek artmıştır. Doğal derin ötektik çözücüler (DDÖÇ), iki veya daha fazla doğal bileşiğin güçlü hidrojen bağları yoluyla etkileşime girmesi sonucu oluşan ve ayarlanabilir fizikokimyasal özellikler sergileyen yenilikçi çözücü sistemleri olarak tanımlanmaktadır. Literatürde, DDÖÇ kullanılarak fenolik bileşikler, flavonoidler, alkaloidler, terpenoidler ve saponinler gibi çeşitli sekonder metabolit gruplarının, klasik çözücülere kıyasla daha yüksek ekstraksiyon verimi, yüksek biyolojik aktivite ve artmış stabilite gösterdikleri bildirilmektedir. Bu derlemede, fitoterapide DDÖÇ kullanımının bilimsel altyapısı, DDÖÇ bileşenleri ve ekstraksiyon prensipleri ile geleneksel çözücü sistemlerine karşı avantajları ve mevcut sınırlamaları ele alınmıştır.

Anahtar Kelimeler

Fitoterapi , doğal derin ötektik çözücüler , DDÖÇ , yeşil kimya , ekstraksiyon , sekonder metabolitler

The use of natural deep eutectic solvents in phytotherapy

Abstract

Phytotherapy is a complementary therapeutic approach rooted in traditional medicine and based on the use of herbal drugs and their biologically active constituents for the prevention and treatment of diseases. Today, the efficacy and safety of phytotherapeutic products depend not only on the plant species used, but also directly on the extraction method and solvent system applied. Organic solvents commonly used in conventional herbal extraction processes present important drawbacks, including toxicity, environmental concerns, limited selectivity, and the risk of residual solvent contamination. For this reason, there is an increasing demand for alternative solvent systems that are compatible with the principles of green chemistry. Natural deep eutectic solvents (NADES) are innovative solvent systems formed by strong hydrogen-bond interactions between two or more natural compounds, resulting in mixtures with tuneable physicochemical properties. Numerous studies have reported that the use of NADES can enhance the extraction efficiency, stability, and biological activity of various classes of secondary metabolites, including phenolic compounds, flavonoids, alkaloids, terpenoids, and saponins, compared to conventional solvents. This review outlines the scientific background of NADES in phytotherapy, discusses their components and extraction mechanisms, and evaluates their advantages and current limitations relative to traditional solvent systems.

Keywords

Phytotherapy , natural deep eutectic solvents , NADES , green chemistry , extraction , secondary metabolites

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Geleneksel, Tamamlayıcı ve Bütünleştirici Tıp (Diğer)

Bölüm

Derleme

Yazarlar

Aysu Günaydın ^*
0000-0001-6726-5511
Türkiye

Mahfuz Elmastaş
0000-0002-1502-1141
Türkiye

Yayımlanma Tarihi

28 Nisan 2026

Gönderilme Tarihi

9 Mart 2026

Kabul Tarihi

18 Nisan 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 7 Sayı: 1

DOI

https://doi.org/10.53445/batd.1906090

IZ

https://izlik.org/JA34DS33AB

APA

Günaydın, A., & Elmastaş, M. (2026). Fitoterapide doğal derin ötektik çözücülerin kullanımı. Journal of Integrative and Anatolian Medicine, 7(1), 15-25. https://doi.org/10.53445/batd.1906090

J. Integr. Anatol. Med. (Kısaltılmış Başlık)

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e-ISSN: 2687-6345

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Bu dergi Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ile lisanslanmıştır.

Fitoterapide doğal derin ötektik çözücülerin kullanımı

Öz

Anahtar Kelimeler

The use of natural deep eutectic solvents in phytotherapy

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

J. Integr. Anatol. Med. (Kısaltılmış Başlık)