Cognitive flexibility among female migraine patients: case–control study
Abstract
Purpose: The aim of this study was to determine if cognition is affected in female migraine sufferers by comparing cognitive domains with a healthy control group.
Materials and Methods: Fifty patients with migraine and 50 healthy controls (all female) were enrolled in this cross-sectional case–control study. The Beck Depression test, Beck Anxiety test, California Verbal Learning Test, Montreal Cognitive Assessment Scale, and Wisconsin Card Sorting Test (WCST) were performed in both groups.
Results: Using a multivariate logistic regression model of migraine, WCST non-perseverative error (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.028–2.568; p = 0.03), WCST percent of perseverative error (OR, 0.23; 95%CI, 0.071–0.786; p = 0.01), WCST perseverative response (OR, 4.55; 95%CI, 1.272–16.298; p = 0.02), no alcohol consumption (OR, 0.006; 95%CI, 0.000–0.943; p = 0.04), family history of hypertension (OR, 4.46; 95%CI, 1.114–17.915; p = 0.03), family history of migraine (OR, 4.028; 95%CI, 1.027–15.799; p = 0.04), and no family history of stroke (OR, 0.034; 95%CI, 0.003–0.448; p = 0.01) were significant factors
Conclusion: Among WCST scores, non-perseverative error provides insight into the patient’s problem solving ability. Meanwhile, percent perseverative error and perseverative response scores provide insight into cognitive flexibility ability. Therefore, in our study group, patients with migraine show better problem solving and cognitive flexibility ability than the healthy control group.
Materials and Methods: Fifty patients with migraine and 50 healthy controls (all female) were enrolled in this cross-sectional case–control study. The Beck Depression test, Beck Anxiety test, California Verbal Learning Test, Montreal Cognitive Assessment Scale, and Wisconsin Card Sorting Test (WCST) were performed in both groups.
Results: Using a multivariate logistic regression model of migraine, WCST non-perseverative error (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.028–2.568; p = 0.03), WCST percent of perseverative error (OR, 0.23; 95%CI, 0.071–0.786; p = 0.01), WCST perseverative response (OR, 4.55; 95%CI, 1.272–16.298; p = 0.02), no alcohol consumption (OR, 0.006; 95%CI, 0.000–0.943; p = 0.04), family history of hypertension (OR, 4.46; 95%CI, 1.114–17.915; p = 0.03), family history of migraine (OR, 4.028; 95%CI, 1.027–15.799; p = 0.04), and no family history of stroke (OR, 0.034; 95%CI, 0.003–0.448; p = 0.01) were significant factors
Conclusion: Among WCST scores, non-perseverative error provides insight into the patient’s problem solving ability. Meanwhile, percent perseverative error and perseverative response scores provide insight into cognitive flexibility ability. Therefore, in our study group, patients with migraine show better problem solving and cognitive flexibility ability than the healthy control group.
Keywords
Kaynakça
- References 1. Leonardi M, Raggi A. Burden of migraine: international perspectives. Neurol Sci 2013; 34(Suppl. 1): S117–S118.
- 2. Bigal ME, Lipton RB. The epidemiology, burden, and comorbidities of migraine. Neurol Clin 2009; 27: 321–334.
- 3. Martins IP, Gil-Gouveia R, Silva C, Maruta C, Oliveira AG. Migraine, headaches, and cognition. Headache. 2012 Nov-Dec;52(10):1471-1482.
- 4. Mulder EJ, Linssen WH, Passchier J, Orlebeke JF, de Geus EJ. Interictal and postictal cognitive changes in migraine. Cephalalgia 1999;19:557-565.
- 5. Lo Buono V, Bonanno L, Corallo F, Palmeri R, Allone C, Lo Presti R, Grugno R, Di Lorenzo G, Bramanti P, Marino S. Cognitive functions and psychological symptoms in migraine: a study on patients with and without aura. Int J Neurosci. 2019 Jun;129(6):588-592.
- 6. Tunç A, Tekeşin AK, Güngen BD, Arda E. Cognitive performance in young and middle-aged adults with migraine: Investigating the correlation with white matter hyperintensities and psychological symptoms. Neurol Neurochir Pol. 2018 Aug;52(4):470-476.
- 7. Pellegrino Baena C, Goulart AC, Santos IS, Suemoto CK, Lotufo PA, Bensenor IJ. Migraine and cognitive function: Baseline findings from the Brazilian Longitudinal Study of Adult Health: ELSA-Brasil. Cephalalgia. 2018 Aug;38(9):1525-1534.
- 8. D’Andrea G, Nertempi P, Milone FF, Joseph R, Cananzi AR. Personality and memory in childhood migraine. Cephalalgia 1989 9:25–28.
- 9. Parisi P, Verrotti A, Paolino MC, Urbano A, Bernabucci M, Castaldo R, Villa MP Headache and cognitive profile in children: a cross-sectional controlled study. J Headache Pain 2010 11(1):45–51
- 10. Moutran AR, Villa TR, Diaz LA, Noffs MH, Pinto MM, Gabbai AA, Carvalho Dde S. Migraine and cognition in children: a controlled study. Arq Neuropsiquiatr 2011 69:192–195
