Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity

Süleyman Özbıçer; Gülhan yüksel Kalkan; Örsan Deniz Urgun; Salim Neşelioğlu; Özcan Erel

doi:10.17826/cumj.976875

TR EN

İskemi modifiye albümin düzeylerinin NSTEMI hastalarını iskemik olmayan kontrollerden ayırt etmedeki rolü ve hastalık şiddeti ile ilişkisi

Öz

Amaç: Bu çalışmada yüksek duyarlılığa sahip kardiyak troponin (hs-cTn) testleri ile tanı konulan erken dönem ST yükselmesiz miyokard infarktüsü (NSTEMI) hastalarında iskemi modifiye albümin (İMA) 'nın tanısal değerini araştırmayı amaçladık. Gereç ve Yöntem: Mart 2018 ve Ağustos 2019 tarihleri arasında hastanemize NSTEMI ile başvuran kardiyovasküler hastalık öyküsü olmayan 126 hasta kaydedildi. Hastaların IMA düzeyleri rastgele seçilen, yaş ve cinsiyet eşleştirilmiş koroner anjiyografi sonuçları normal olan 61 deneğin IMA düzeyleri ile karşılaştırıldı. Bulgular: NSTEMI hastalarının IMA seviyeleri kontrol grubuna göre daha yüksekti. İşlem karakteristiği (ROC) eğri analizinde, 0,3855 ABSU' ya eşit veya daha büyük bir değer, NSTEMI tanısı için %82 duyarlılığa ve%99,4 özgülüğe sahiptir (EAA: 0,962, %95 CI: 0,937 – 0,986). Ek olarak, ROC eğrisi analizi, üç damar hastalığını ayırt etmek için orta düzeyde tahmin gücü ortaya koydu (sınır değeri: 0,4290 ABSU, duyarlılık %78,4 ve özgüllük %56,3, EAA: 0,696, %95 CI: 0,616 – 0,776). İMA düzeyleri ile hasta grubunun Gensini puanları arasında pozitif korelasyon vardı. Sonuç: İskemi modifiye albümin tek başına kullanıldığında, NSTEMI' yi iskemik olmayan kontrollerden ayırt etmede oldukça yararlı olmuştur. Ayrıca, IMA seviyeleri KAH şiddeti ile pozitif korelasyon gösteriyordu.

Anahtar Kelimeler

Miyokard Enfarktüsü, Sülfidril Bileşikleri, Ateroskleroz

Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity

Öz

Purpose: The aim of this study was to investigate the diagnostic value of ischemia modified albumin (IMA) in early non-ST elevation myocardial infarction (NSTEMI) patients diagnosed with high-sensitive cardiac troponin (hs-cTn)assays. Materials and Methods: In the first three hours of symptom onset, one hundred sixty-two patients without cardiovascular disease history admitted to our hospital with NSTEMI were enrolled between March 2018 and August 2019. The patients' IMA levels were compared with IMA levels of randomly selected, age and the sex-matched control group comprised of 61 subjects with normal coronary angiography results. Results: IMA levels of NSTEMI patients were higher than the control group. In receiver operating characteristic (ROC) curve analysis, a value equal or greater than 0.3855 ABSU has an 82% sensitivity and a 99.4% specificity for diagnosing NSTEMI (AUC: 0.962, 95% CI: 0.937 – 0.986,). In addition, ROC curve analysis revealed moderate predictive power for distinguishing three-vessel disease (cut-off value: 0.4290 ABSU, sensitivity 78.4% and specificity 56.3%, AUC: 0.696, 95% CI: 0.616 – 0.776,). IMA levels were positively correlated with Gensini scores of the patient group. Conclusion: Ischemia-modified albumin, when used alone, was very useful in distinguishing NSTEMI from non-ischemic controls. Besides, IMA levels were positively correlated with CAD severity.

Anahtar Kelimeler

Myocardial Infarction, Sulfhydryl Compounds, Atherosclerosis

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Süleyman Özbıçer ^*
0000-0002-2016-0672
Türkiye

Gülhan yüksel Kalkan
0000-0002-6089-761X
Türkiye

Örsan Deniz Urgun
0000-0001-9125-4732
Türkiye

Salim Neşelioğlu
0000-0001-9125-4732
Türkiye

Özcan Erel
0000-0002-2996-3236
Türkiye

Yayımlanma Tarihi

30 Aralık 2021

Gönderilme Tarihi

7 Ağustos 2021

Kabul Tarihi

3 Ekim 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 46 Sayı: 4

DOI

https://doi.org/10.17826/cumj.976875

IZ

https://izlik.org/JA22DJ39EA

APA

Özbıçer, S., Kalkan, G., Urgun, Ö. D., Neşelioğlu, S., & Erel, Ö. (2021). Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity. Cukurova Medical Journal, 46(4), 1566-1573. https://doi.org/10.17826/cumj.976875

AMA

1.Özbıçer S, Kalkan G, Urgun ÖD, Neşelioğlu S, Erel Ö. Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity. Cukurova Med J. 2021;46(4):1566-1573. doi:10.17826/cumj.976875

Chicago

Özbıçer, Süleyman, Gülhan yüksel Kalkan, Örsan Deniz Urgun, Salim Neşelioğlu, ve Özcan Erel. 2021. “Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity”. Cukurova Medical Journal 46 (4): 1566-73. https://doi.org/10.17826/cumj.976875.

EndNote

Özbıçer S, Kalkan G, Urgun ÖD, Neşelioğlu S, Erel Ö (01 Aralık 2021) Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity. Cukurova Medical Journal 46 4 1566–1573.

IEEE

[1]S. Özbıçer, G. Kalkan, Ö. D. Urgun, S. Neşelioğlu, ve Ö. Erel, “Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity”, Cukurova Med J, c. 46, sy 4, ss. 1566–1573, Ara. 2021, doi: 10.17826/cumj.976875.

ISNAD

Özbıçer, Süleyman - Kalkan, Gülhan yüksel - Urgun, Örsan Deniz - Neşelioğlu, Salim - Erel, Özcan. “Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity”. Cukurova Medical Journal 46/4 (01 Aralık 2021): 1566-1573. https://doi.org/10.17826/cumj.976875.

JAMA

1.Özbıçer S, Kalkan G, Urgun ÖD, Neşelioğlu S, Erel Ö. Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity. Cukurova Med J. 2021;46:1566–1573.

MLA

Özbıçer, Süleyman, vd. “Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity”. Cukurova Medical Journal, c. 46, sy 4, Aralık 2021, ss. 1566-73, doi:10.17826/cumj.976875.

Vancouver

1.Süleyman Özbıçer, Gülhan yüksel Kalkan, Örsan Deniz Urgun, Salim Neşelioğlu, Özcan Erel. Ischemia modified albumin levels in distinguishing NSTEMI patients from non-ischemic controls and correlation with disease severity. Cukurova Med J. 01 Aralık 2021;46(4):1566-73. doi:10.17826/cumj.976875